Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Permanent cell line expressing human factor VIII-related antigen established by hybridization.

1983 • 1,458 citations

Protease-activated receptor 3 is a second thrombin receptor in humans

1997 • 878 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine

1997 • 492 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin.

1984 • 442 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

The Proteinase-activated Receptor 2 Is Induced by Inflammatory Mediators in Human Endothelial Cells

1996 • 352 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Myosin light chain kinase in endothelium: molecular cloning and regulation.

1997 • 200 citations

The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells.

1996 • 183 citations

Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.

1982 • 182 citations

Induction of phagocytic behaviour in human epithelial cells by Escherichia coli cytotoxic necrotizing factor type1

1993 • 175 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Endothelial Cell Thrombin Receptors and PAR-2

1997 • 165 citations

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1983 • 164 citations

The GTPase-Activating Protein n-Chimaerin Cooperates with Rac1 and Cdc42Hs To Induce the Formation of Lamellipodia and Filopodia

1996 • 152 citations

Inhibition of RhoA Translocation and Calcium Sensitization by In Vivo ADP-Ribosylation with the Chimeric Toxin DC3B

1997 • 151 citations

Regulation of Thrombin-Mediated Endothelial Cell Contraction and Permeability

1996 • 121 citations

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.

1996 • 112 citations

Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase

1997 • 100 citations

Regulation of Thrombin Receptors on Human Umbilical Vein Endothelial Cells

1995 • 100 citations

A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly.

1993 • 96 citations

Sequestration of a G-protein βγ Subunit or ADP-ribosylation of Rho Can Inhibit Thrombin-induced Activation of Platelet Phosphoinositide 3-Kinases

1995 • 93 citations

Mechanisms of Cholera Toxin Prevention of Thrombin- and PMA-Induced Endothelial Cell Barrier Dysfunction

1994 • 78 citations

Evidence that Vascular Endothelial Cells Can Induce the Retraction of Fibrin Clots

1981 • 58 citations

Bradykinin- and thrombin-induced increases in endothelial permeability occur independently of phospholipase C but require protein kinase C activation

1997 • 54 citations

Signaling Pathways of the Thrombin Receptor

1993 • 51 citations

Platelet Tyrosine-Specific Protein Phosphorylation Is Regulated by Thrombin

1988 • 50 citations

Thrombin-induced Lung Vascular Injury

1983 • 47 citations

Thrombin-induced alterations in lung fluid balance in awake sheep

1985 • 43 citations

Thrombin and Its Receptor in Growth Control^a

1995 • 18 citations

Thrombin-Induced Alterations in Endothelial Cell Cytoarchitectural and Functional Properties

1994 • 7 citations