Intersectin Can Regulate the Ras/MAP Kinase Pathway Independent of Its Role in Endocytosis

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

1998 • 576 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.

1994 • 356 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Phosphatidylinositol polyphosphate binding to the mammalian septin H5 is modulated by GTP

1999 • 320 citations

Regulation of signal transduction by endocytosis

2000 • 299 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains

1998 • 291 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15

1999 • 236 citations

Inhibition of Clathrin-Mediated Endocytosis Selectively Attenuates Specific Insulin Receptor Signal Transduction Pathways

1998 • 215 citations

Dap160, a Neural-specific Eps15 Homology and Multiple SH3 Domain-containing Protein That Interacts with DrosophilaDynamin

1998 • 205 citations

Splice Variants of Intersectin Are Components of the Endocytic Machinery in Neurons and Nonneuronal Cells

1999 • 180 citations

Identification of the Mitogen-Activated Protein Kinase Phosphorylation Sites on Human Sosl That Regulate Interaction with Grb2

1996 • 172 citations

The endocytic machinery in nerve terminals surrounds sites of exocytosis

1999 • 172 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

EHSH1/Intersectin, a Protein That Contains EH and SH3 Domains and Binds to Dynamin and SNAP-25

1999 • 163 citations

Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway

1998 • 159 citations

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1995 • 154 citations

A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.

1985 • 151 citations

Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21 in Fibroblasts

1999 • 151 citations

U50,488H-induced Internalization of the Human κ Opioid Receptor Involves a β-Arrestin- and Dynamin-dependent Mechanism

1999 • 147 citations

Role of Arrestins in Endocytosis and Signaling of α2-Adrenergic Receptor Subtypes

1999 • 136 citations

Requirement of Receptor Internalization for Opioid Stimulation of Mitogen-Activated Protein Kinase: Biochemical and Immunofluorescence Confocal Microscopic Evidence

1999 • 127 citations

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

1994 • 119 citations

Regulation of Muscarinic Acetylcholine Receptor Sequestration and Function by β-Arrestin

1999 • 114 citations

Stimulation of Mitogen-activated Protein Kinase by G Protein-coupled α2-Adrenergic Receptors Does Not Require Agonist-elicited Endocytosis

1999 • 105 citations

Regulatory Role of SH3 Domain-mediated Protein–Protein Interactions in Synaptic Vesicle Endocytosis

1999 • 103 citations

Two Isoforms of a Human Intersectin (ITSN) Protein Are Produced by Brain-Specific Alternative Splicing in a Stop Codon

1998 • 102 citations

Disassembly of Son-of-sevenless Proteins from Grb2 during p21 Desensitization by Insulin

1995 • 99 citations

The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

2000 • 94 citations

Tissue-specific Alternative Splicing Generates Two Synaptojanin Isoforms with Differential Membrane Binding Properties

1996 • 92 citations

Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways

2000 • 90 citations

MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.

1995 • 85 citations

Activation of the Mitogen-activated Protein Kinase Pathway by a Gq/11-coupled Muscarinic Receptor Is Independent of Receptor Internalization

1999 • 83 citations

Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors

1999 • 70 citations

Intersectin, an Adaptor Protein Involved in Clathrin-mediated Endocytosis, Activates Mitogenic Signaling Pathways

2000 • 68 citations

Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: phenylarsine oxide-sensitive and -insensitive pathways.

1992 • 31 citations

Insulin Receptor-mediated Dissociation of Grb2 from Sos Involves Phosphorylation of Sos by Kinase(s) Other than Extracellular Signal-regulated Kinase

1998 • 21 citations