Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE

1955 • 791 citations

Src Tyrosine Kinases, Gα Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin

1996 • 770 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

1996 • 692 citations

Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins

1997 • 658 citations

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1994 • 646 citations

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

1995 • 612 citations

Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy

1998 • 590 citations

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

1996 • 566 citations

Caveolae and caveolins

1996 • 549 citations

Oligomeric structure of caveolin: implications for caveolae membrane organization.

1995 • 547 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Reduction of caveolin and caveolae in oncogenically transformed cells.

1995 • 505 citations

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1998 • 473 citations

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.

1995 • 465 citations

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1998 • 435 citations

STRUCTURAL MODULATIONS OF PLASMALEMMAL VESICLES

1968 • 427 citations

Recombinant Expression of Caveolin-1 in Oncogenically Transformed Cells Abrogates Anchorage-independent Growth

1997 • 377 citations

Caveolin-3 Associates with Developing T-tubules during Muscle Differentiation

1997 • 345 citations

Caveolin Is an Activator of Insulin Receptor Signaling

1998 • 297 citations

Cellular aspects of transcapillary exchange

1983 • 277 citations

Caveolin-3 in muscular dystrophy

1998 • 230 citations

Genes encoding human caveolin‐1 and ‐2 are co‐localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

1998 • 227 citations

Expression and Characterization of Recombinant Caveolin

1996 • 223 citations

Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo

1998 • 215 citations

Oligomerization of VIP21‐caveolin in vitro is stabilized by long chain fatty acylation or cholesterol

1996 • 205 citations

Caveolin-1 Interacts with the Insulin Receptor and Can Differentially Modulate Insulin Signaling in Transfected Cos-7 Cells and Rat Adipose Cells

1999 • 188 citations

Molecular Genetics of the Caveolin Gene Family: Implications for Human Cancers, Diabetes, Alzheimer Disease, and Muscular Dystrophy

1998 • 184 citations

A photo‐reactive derivative of ganglioside GM1 specifically cross‐links VIP21‐caveolin on the cell surface

1995 • 181 citations

Regulation of G Protein-coupled Receptor Kinases by Caveolin

1999 • 173 citations

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer

1992 • 168 citations

Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1.

1994 • 160 citations

Phenotypic Behavior of Caveolin-3 Mutations That Cause Autosomal Dominant Limb Girdle Muscular Dystrophy (LGMD-1C)

1999 • 158 citations

Sequence and detailed organization of the human caveolin‐1 and ‐2 genes located near the D7S522 locus (7q31.1)

1999 • 151 citations

Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav‐1, ‐2, and ‐3)

1998 • 144 citations

Baculovirus-based Expression of Mammalian Caveolin in Sf21 Insect Cells

1996 • 134 citations

Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression.

1995 • 123 citations

RNA Genetics of Breast Cancer: Maspin as Paradigm

1994 • 123 citations

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

1994 • 120 citations

Molecular and Cellular Biology of Caveolae

1997 • 120 citations

Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene.

1995 • 116 citations

Chromosome 7q allelic losses in pancreatic carcinoma.

1996 • 99 citations

Identification, Sequence, and Expression of an Invertebrate Caveolin Gene Family from the Nematode Caenorhabditis elegans

1997 • 89 citations

Prognostic significance of allelic imbalance of chromosome arms 7q, 8p, 16q, and 18q in stage T3N0M0 prostate cancer.

1998 • 84 citations

A molecular cytogenetic analysis of 7q31 in prostate cancer.

1998 • 82 citations

Cytogenetic profile of uterine sarcomas

1993 • 78 citations

Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer

1998 • 78 citations

Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene.

1995 • 71 citations

Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas

1997 • 68 citations

Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer

1997 • 56 citations

A mutation (Trp1193?Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

1993 • 49 citations

Functional Properties of a Naturally Occurring Trp¹²⁰⁰→ Ser¹²⁰⁰Mutation of the Insulin Receptor

1990 • 48 citations

Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET.

1996 • 41 citations

Localization of a tumour-suppressor gene associated with human oral cancer on 7q31.1

1998 • 41 citations

Allelic loss on chromosome 7q in ovarian adenocarcinomas: two critical regions and a rearrangement of the PLANH1 locus.

1996 • 39 citations

Loss of heterozygosity of chromosome 9p21 and 7q31 is correlated with high incidence of recurrent tumor in head and neck squamous cell carcinoma.

1998 • 30 citations

Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis

1995 • 28 citations

Localization of the human caveolin‐3 gene to the D3S18/D3S4163/D3S4539 locus (3p25), in close proximity to the human oxytocin receptor gene

1999 • 27 citations

[A preliminary cytogenetic study of uterine leiomyoma].

1993 • 3 citations