Filamins as integrators of cell mechanics and signalling

Rho GTPases and their effector proteins

2000 • 1,941 citations

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia

1998 • 858 citations

Structural interaction of cytoskeletal components

1981 • 766 citations

Actin-Binding Protein Requirement for Cortical Stability and Efficient Locomotion

1992 • 567 citations

Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins

2000 • 558 citations

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.

1990 • 522 citations

Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling

2000 • 476 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

Membrane Tether Formation from Blebbing Cells

1999 • 423 citations

Mechanisms of actin rearrangements mediating platelet activation.

1992 • 413 citations

Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages.

1975 • 388 citations

Cytoplasmic Structure and Contractility in Amoeboid Cells

1979 • 343 citations

Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells.

1975 • 317 citations

A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280

1998 • 313 citations

Identification of Filamin as a Novel Ligand for Caveolin-1: Evidence for the Organization of Caveolin-1–associated Membrane Domains by the Actin Cytoskeleton

2000 • 303 citations

Filamin 2 (FLN2): A Muscle-specific Sarcoglycan Interacting Protein

2000 • 290 citations

Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis.

1976 • 289 citations

Actin polymerization and intracellular solvent flow in cell surface blebbing.

1995 • 273 citations

The Role of Actin-binding Protein 280 in Integrin-dependent Mechanoprotection

1998 • 258 citations

The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

2000 • 242 citations

Resemblance of actin-binding protein/actin gels to covalently crosslinked networks

1990 • 240 citations

The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.

1991 • 233 citations

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

2000 • 232 citations

Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor Stimulation

1999 • 199 citations

The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages.

1986 • 196 citations

Indications for a Novel Muscular Dystrophy Pathway

2000 • 195 citations

Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments

1981 • 188 citations

Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-α Activation of SAPK in Melanoma Cells

1997 • 169 citations

Interactions between actin, myosin, and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin Mg-2+-adenosine triphosphatase requires a cofactor for activation by actin.

1975 • 162 citations

The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development

1996 • 161 citations

Characterization of muscle filamin isoforms suggests a possible role of ?-filamin/ABP-L in sarcomeric Z-disc formation

2000 • 159 citations

Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein Filamin

2000 • 159 citations

Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments.

1980 • 156 citations

The gelation of actin by actin-binding protein.

1978 • 155 citations

Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.

1989 • 151 citations

Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway

1997 • 141 citations

Purification and properties of filamin, and actin binding protein from chicken gizzard.

1976 • 141 citations

In situ Phosphorylation of Platelet Actin-binding Protein by cAMP-dependent Protein Kinase Stabilizes It against Proteolysis by Calpain

1989 • 138 citations

Localization and Enhanced Current Density of the Kv4.2 Potassium Channel by Interaction with the Actin-Binding Protein Filamin

2000 • 136 citations

Modulation of Dopamine D₂Receptor Signaling by Actin-Binding Protein (ABP-280)

2000 • 132 citations

The Dictyostelium gelation factor shares a putative actin binding site with alpha-actinins and dystrophin and also has a rod domain containing six 100-residue motifs that appear to have a cross-beta conformation.

1989 • 132 citations

Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2

2000 • 131 citations

Actin crosslinking proteins at the leading edge

1994 • 128 citations

Interaction of Presenilins with the Filamin Family of Actin-Binding Proteins

1998 • 125 citations

Targeted disruption of the ABP-120 gene leads to cells with altered motility.

1992 • 125 citations

Ultrastructural localization of alpha-actinin and filamin in cultured cells with the immunogold staining (IGS) method.

1984 • 124 citations

Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein.

1983 • 120 citations

Human β-Filamin Is a New Protein That Interacts with the Cytoplasmic Tail of Glycoprotein Ibα

1998 • 114 citations

Drosophila Filamin encoded by the cheerio locus is a component of ovarian ring canals

1999 • 111 citations

Isolation and some properties of macrophage .alpha.-actinin: evidence that it is not an actin gelling protein

1984 • 109 citations

Identification and Characterization of cvHsp

1999 • 108 citations

Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc Receptor I (FcγRI)

1991 • 106 citations

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

2000 • 104 citations

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators

1997 • 102 citations

Identification of a short sequence essential for actin binding by Dictyostelium ABP-120.

1990 • 93 citations

Arp2/3 Complex fromAcanthamoebaBinds Profilin and Cross-links Actin Filaments

1998 • 92 citations

Ca2+-Activated, phospholipid-dependent protein kinase catalyzes the phosphorylation of actin-binding proteins

1984 • 91 citations

Identification of the Region in Actin-binding Protein that Binds to the Cytoplasmic Domain of Glycoprotein Ibä

1997 • 90 citations

The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold

1997 • 88 citations

Structural comparison of several actin-binding macromolecules.

1980 • 87 citations

Purification of mammalian filamin. Similarity to high molecular weight actin-binding protein in macrophages, platelets, fibroblasts, and other tissues.

1978 • 85 citations

Molecular Cloning of Human ABPL, an Actin-Binding Protein Homologue

1998 • 83 citations

Morphogenesis of liposomes encapsulating actin depends on the type of actin-crosslinking

1999 • 83 citations

Filamin Is Required for Ring Canal Assembly and Actin Organization during Drosophila Oogenesis

1999 • 82 citations

Cyclic AMP-dependent phosphorylation of filamin in mammalian smooth muscle

1978 • 79 citations

Formation of the Drosophila Ovarian Ring Canal Inner Rim Depends on cheerio

1997 • 77 citations

Structural basis for dimerization of the Dictyostelium gelation factor (ABP120) rod.

1999 • 76 citations

Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7

1993 • 76 citations

Phosphorylation of Actin-binding Protein 280 by Growth Factors Is Mediated by p90 Ribosomal Protein S6 Kinase

1996 • 71 citations

Actin Filament Crosslinking by Chicken Gizzard Filamin Is Regulated by Phosphorylation in Vitro

1995 • 69 citations

Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods.

1995 • 69 citations

The filamins: properties and functions

1985 • 69 citations

Three actin cross-linking proteins, the 34 kDa actin-bundling protein, α-actinin and gelation factor (ABP-120), have both unique and redundant roles in the growth and development of Dictyostelium

1999 • 68 citations

Identification of a high molecular weight actin-binding protein in skeletal muscle.

1979 • 68 citations

Analysis of filamin and α‐actinin binding to actin by the stopped flow method

1993 • 68 citations

Determination of a cAMP-Dependent Protein Kinase Phosphorylation Site in the C-Terminal Region of Human Endothelial Actin-Binding Protein

2000 • 65 citations

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1999 • 65 citations

Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants.

1996 • 65 citations

Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.

1988 • 63 citations

A Novel Human Actin-Binding Protein Homologue That Binds to Platelet Glycoprotein Ib

1998 • 61 citations

Evidence that a 27-residue sequence is the actin-binding site of ABP-120

1991 • 59 citations

Identification and cellular localization of the actin‐binding protein ABP‐120 from Entamoeba histolytica

1996 • 50 citations

Photosensory and thermosensory responses in Dictyostelium slugs are specifically impaired by absence of the F-actin cross-linking gelation factor (ABP-120)

1997 • 48 citations

A new protein that gels F actin in the cell cortex of Dictyostelium discoideum

1981 • 45 citations

Isolation of a new actin‐binding protein from dictyostelium discoideum

1982 • 43 citations

Characterization of the actin binding site on smooth muscle filamin.

1994 • 41 citations

Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family

2000 • 38 citations

Actin-binding and dimerization domains of HeLa cell filamin

1988 • 37 citations

Actin-Binding Protein (ABP-280) Filamin Gene (FLN) Maps Telomeric to the Color Vision Locus (R/GCP) and Centromeric to G6PD in Xq28

1993 • 37 citations

Physical and genetic interaction of filamin with presenilin in Drosophila

2000 • 36 citations

Regulation of water flow by actin-binding protein-induced actin gelatin

1992 • 34 citations

Molecular architecture of the rod domain of the Dictyostelium gelation factor (ABP120)

1999 • 34 citations

Severe developmental defects in Dictyostelium null mutants for actin-binding proteins

2000 • 34 citations

Fine structure of gels prepared from an actin‐binding protein and actin: Comparison to cytoplasmic extracts and cortical cytoplasm in amoeboid cells of Dictyostelium discoideum

1986 • 31 citations

Molecular characterization of a multi-promoter gene encoding a chicken filamin protein.

1993 • 28 citations

Viscoelastic Properties of F-Actin Solutions in the Presence of Normal and Mutated Actin-Binding Proteins

1996 • 28 citations

Assignment<footref rid="foot01"><sup>1</sup></footref> of human filamin gene FLNB to human chromosome band 3p14.3 and identification of YACs containing the complete FLNB transcribed region

1999 • 15 citations