Integrin signaling to the actin cytoskeleton

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Molecular complexity and dynamics of cell-matrix adhesions

2001 • 1,091 citations

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

2002 • 820 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

1998 • 668 citations

Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins

2001 • 667 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

2002 • 569 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

2002 • 436 citations

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin

2002 • 432 citations

RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity

2001 • 431 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides.

1996 • 410 citations

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

2002 • 405 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

Recruitment of the Arp2/3 complex to vinculin

2002 • 401 citations

Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

2001 • 400 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

2003 • 375 citations

Protein kinase C involvement in focal adhesion formation

1992 • 361 citations

Syndecan-4 signals cooperatively with integrins in a Rhodependent manner in the assembly of focal adhesions and actin stress fibers

1999 • 360 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Paxillin interactions

2000 • 342 citations

DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane

1996 • 339 citations

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.

1993 • 335 citations

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

2002 • 326 citations

The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

2002 • 322 citations

Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides

2001 • 316 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

2003 • 307 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts

1999 • 284 citations

Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.

1988 • 279 citations

Receptor protein tyrosine phosphatase α activates Src-family kinases and controls integrin-mediated responses in fibroblasts

1999 • 273 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

1999 • 257 citations

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility

1999 • 254 citations

Modulation of Fibroblast Morphology and Adhesion during Collagen Matrix Remodeling

2002 • 247 citations

Mechanical control of cyclic AMP signalling and gene transcription through integrins

2000 • 245 citations

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2

1999 • 219 citations

Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A

2000 • 214 citations

An intramolecular association between the head and tail domains of vinculin modulates talin binding.

1994 • 212 citations

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

2000 • 210 citations

Syndecan-4 and focal adhesion function

2001 • 209 citations

Rhoa Function in Lamellae Formation and Migration Is Regulated by the α6β4 Integrin and Camp Metabolism

2000 • 208 citations

Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF

2003 • 208 citations

Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn

1999 • 207 citations

Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants

1997 • 205 citations

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration

2003 • 201 citations

RPTP-α acts as a transducer of mechanical force on αv/β3-integrin–cytoskeleton linkages

2003 • 199 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

Control of morphology, cytoskeleton and migration by syndecan-4

1999 • 191 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

Mechanisms contributing to the activity of integrins on leukocytes

2002 • 181 citations

Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin

1998 • 176 citations

Collagen I Initiates Endothelial Cell Morphogenesis by Inducing Actin Polymerization through Suppression of Cyclic AMP and Protein Kinase A

2002 • 173 citations

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration

2002 • 173 citations

Regulation of G Protein-linked Guanine Nucleotide Exchange Factors for Rho, PDZ-RhoGEF, and LARG by Tyrosine Phosphorylation

2002 • 155 citations

Vav Family Proteins Couple to Diverse Cell Surface Receptors

2000 • 148 citations

Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

2003 • 147 citations

Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2

1998 • 145 citations

Protein Kinase A Regulates Rac and Is Required for the Growth Factor-stimulated Migration of Carcinoma Cells

2001 • 143 citations

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility

2000 • 143 citations

The Wiskott-Aldrich Syndrome Protein-interacting Protein (WIP) Binds to the Adaptor Protein Nck

1998 • 139 citations

The protein tyrosine phosphatase Shp-2 regulates RhoA activity

2000 • 138 citations

Thy-1 binds to integrin β3 on astrocytes and triggers formation of focal contact sites

2001 • 138 citations

Regulation of Fibroblast Motility by the Protein Tyrosine Phosphatase PTP-PEST

1999 • 136 citations

PTPα regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration

2003 • 135 citations

Fibronectin Regulates Assembly of Actin Filaments and Focal Contacts in Cultured Cells via the Heparin-binding Site in Repeat III₁₃

1999 • 130 citations

Involvement of an SHP-2-Rho Small G Protein Pathway in Hepatocyte Growth Factor/Scatter Factor–induced Cell Scattering

2000 • 127 citations

Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps

2000 • 117 citations

Integrin-mediated Muscle Cell Spreading

1999 • 105 citations

Polyphosphoinositides Inhibit the Interaction of Vinculin with Actin Filaments

1999 • 104 citations

Vav2 is required for cell spreading

2001 • 100 citations

Differential regulation of Rho GTPases by β1 and β3 integrins: the role of an extracellular domain of integrin in intracellular signaling

2002 • 97 citations

PTP-PEST controls motility through regulation of Rac1

2002 • 96 citations

Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway

2002 • 85 citations

Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation

2002 • 84 citations

Regulation of Vasodilator-stimulated Phosphoprotein Phosphorylation and Interaction with Abl by Protein Kinase A and Cell Adhesion

2002 • 83 citations

Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain

2002 • 82 citations

Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway.

1994 • 75 citations

Interaction of tumour promoters with epithelial cells in culture

1985 • 71 citations

Interaction between the Amino-terminal SH3 Domain of CRK and Its Natural Target Proteins

1996 • 70 citations

N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator

2002 • 69 citations

Protein Kinase A-mediated Phosphorylation of the Gα13 Switch I Region Alters the Gαβγ13-G Protein-coupled Receptor Complex and Inhibits Rho Activation

2002 • 64 citations

The integrin β tail is required and sufficient to regulate adhesion signaling to Rac1

2002 • 64 citations

Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A

2001 • 60 citations

A Fragment of Paxillin Binds the α4Integrin Cytoplasmic Domain (Tail) and Selectively Inhibits α4-Mediated Cell Migration

2002 • 56 citations

Inhibition of the tyrosine kinase activity of the fibroblast growth factor receptor by the methyltransferase inhibitor 5'-methylthioadenosine.

1993 • 56 citations

Cyclic AMP and Protein Kinase A Stimulate Cdc42: Role of A₂Adenosine Receptors in Human Mast Cells

2000 • 56 citations

The Carboxyl-terminal Tyrosine Residue of Protein-tyrosine Phosphatase α Mediates Association with Focal Adhesion Plaques

2000 • 50 citations