Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1997 • 38,984 citations

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

[29] Preparation of selenomethionyl proteins for phase determination

1997 • 861 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

The Dbl family of oncogenes

1996 • 497 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

2001 • 357 citations

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

2000 • 356 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Miscellaneous Algorithms for Density Modification

1998 • 286 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Dbl family proteins

1997 • 260 citations

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

2000 • 250 citations

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

2002 • 221 citations

Isolation of a new human oncogene from a diffuse B-cell lymphoma

1985 • 210 citations

Rho proteins induce metastatic properties in vivo

1997 • 160 citations

The Faciogenital Dysplasia Gene Product FGD1 Functions as a Cdc42Hs-specific Guanine-Nucleotide Exchange Factor

1996 • 158 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

Signaling to the Rho GTPases: networking with the DH domain

2002 • 136 citations

Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA

2001 • 124 citations

Identification and Characterization of hPEM-2, a Guanine Nucleotide Exchange Factor Specific for Cdc42

1999 • 123 citations

Trp56 of Rac1 Specifies Interaction with a Subset of Guanine Nucleotide Exchange Factors

2001 • 114 citations

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

1999 • 108 citations

[31] Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement

1997 • 102 citations

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

2001 • 96 citations

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

2001 • 92 citations

[9] Guanine nucleotide exchange catalyzed by dbl oncogene product

1995 • 76 citations

Mitogenesis and endocytosis: What's at the INTERSECTIoN?

2001 • 53 citations

Generation of reactive oxygen species by human mesothelioma cells

1999 • 52 citations

Bacterial expressed DH and DH/PH domains

2000 • 30 citations

Signal transduction pathways regulated by the Rho family of small GTPases.

1999 • 29 citations

Biochemical analysis of regulation of Vav, a guanine-nucleotide exchange factor for Rho family of GTPases

2000 • 8 citations