Rho and Rac Take Center Stage

Rho GTPases in cell biology

2002 • 4,662 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Biology of the p21-Activated Kinases

2003 • 1,073 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Filamins as integrators of cell mechanics and signalling

2001 • 987 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Rac Downregulates Rho Activity

1999 • 840 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

2002 • 820 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens

1997 • 759 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

2003 • 690 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Differential Localization of Rho Gtpases in Live Cells

2001 • 686 citations

Localized Rac Activation Dynamics Visualized in Living Cells

2000 • 667 citations

Rho GTPase-activating proteins in cell regulation

2002 • 608 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

2002 • 569 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

RhoA is required for monocyte tail retraction during transendothelial migration

2001 • 498 citations

Integrin signaling to the actin cytoskeleton

2003 • 497 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Rho GTPases and their effector proteins

2000 • 461 citations

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

2002 • 452 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity

2001 • 431 citations

The Mouse Formin mDia1 Is a Potent Actin Nucleation Factor Regulated by Autoinhibition

2003 • 430 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

2002 • 405 citations

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

2001 • 404 citations

Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

2001 • 400 citations

Atypical Rho GTPases Have Roles in Mitochondrial Homeostasis and Apoptosis

2003 • 395 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

2001 • 387 citations

Role of citron kinase as a target of the small GTPase Rho in cytokinesis

1998 • 385 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

2003 • 334 citations

EPS8 and E3B1 transduce signals from Ras to Rac

1999 • 329 citations

Cell–cell adhesion and signalling

2002 • 327 citations

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

2002 • 318 citations

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

2002 • 316 citations

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

1999 • 315 citations

Structural mimicry in bacterial virulence

2001 • 310 citations

RhoA and ROCK Promote Migration by Limiting Membrane Protrusions

2003 • 304 citations

RhoE Binds to ROCK I and Inhibits Downstream Signaling

2003 • 300 citations

RhoA is required for cortical retraction and rigidity during mitotic cell rounding

2003 • 298 citations

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

1998 • 278 citations

Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks

2000 • 274 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration

2001 • 261 citations

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

2003 • 260 citations

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

1999 • 255 citations

Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB

1999 • 255 citations

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

2001 • 251 citations

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

2003 • 237 citations

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

1997 • 234 citations

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

2001 • 223 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

2001 • 214 citations

Regulation of the Association of Adducin with Actin Filaments by Rho-associated Kinase (Rho-kinase) and Myosin Phosphatase

1998 • 209 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

DBC2 , a candidate for a tumor suppressor gene involved in breast cancer

2002 • 207 citations

Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension

2000 • 206 citations

Regulation of epidermal growth factor receptor traffic by the small GTPase RhoB

1999 • 199 citations

Regulation of Tiam1–Rac signalling

2003 • 193 citations

Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice

2000 • 192 citations

ADP-Ribosylation Factor 6 Regulates Actin Cytoskeleton Remodeling in Coordination with Rac1 and RhoA

2000 • 173 citations

Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

2002 • 171 citations

Identification of a novel Rac1-interacting protein involved in membrane ruffling.

1996 • 171 citations

Bacterial Toxins That Modify The Actin Cytoskeleton

2002 • 165 citations

Cadherin Engagement Inhibits RhoA via p190RhoGAP

2003 • 164 citations

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs

1998 • 162 citations

Cdc42hs Facilitates Cytoskeletal Reorganization and Neurite Outgrowth by Localizing the 58-Kd Insulin Receptor Substrate to Filamentous Actin

2001 • 159 citations

RhoB Alteration Is Necessary for Apoptotic and Antineoplastic Responses to Farnesyltransferase Inhibitors

2000 • 158 citations

Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes

1998 • 158 citations

The GTPase-Activating Protein n-Chimaerin Cooperates with Rac1 and Cdc42Hs To Induce the Formation of Lamellipodia and Filopodia

1996 • 152 citations

The Rho GTPase family: a Racs to Wrchs story

2002 • 142 citations

Protein Kinase C Induces Actin Reorganization via a Src- and Rho-dependent Pathway

2002 • 136 citations

Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in Endothelial Cells

2002 • 132 citations

XPLN, a Guanine Nucleotide Exchange Factor for RhoA and RhoB, But Not RhoC

2002 • 131 citations

Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

1998 • 131 citations

Paxillin–ARF GAP signaling and the cytoskeleton

2001 • 131 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 • 114 citations

Arfaptin 1, a Putative Cytosolic Target Protein of ADP-ribosylation Factor, Is Recruited to Golgi Membranes

1997 • 112 citations

Induced Expression of Rnd3 Is Associated with Transformation of Polarized Epithelial Cells by the Raf–MEK–Extracellular Signal-Regulated Kinase Pathway

2000 • 104 citations

The Pleckstrin Homology Domain of Phospholipase C-β2 as an Effector Site for Rac

2003 • 101 citations

RhoG Signals in Parallel with Rac1 and Cdc42

2002 • 100 citations

Regulation of Ras-related RhoB protein expression during the cell cycle.

1995 • 84 citations

A Novel Strategy for Specifically Down-regulating Individual Rho GTPase Activity in Tumor Cells

2003 • 74 citations

Yop effectors of Yersinia spp. and actin rearrangements

2000 • 61 citations

Cloning and Functional Characterization of Related TC10 Isoforms, a Subfamily of Rho Proteins Involved in Insulin-stimulated Glucose Transport

2002 • 57 citations

Differential Binding of Arfaptin 2/POR1 to ADP-Ribosylation Factors and Rac1

2001 • 54 citations

Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo

2002 • 46 citations

RhoB, Not RhoA, Represses the Transcription of the Transforming Growth Factor β Type II Receptor by a Mechanism Involving Activator Protein 1

2002 • 43 citations

Phospholipase C‐γ, protein kinase C and Ca²⁺/calmodulin‐dependent protein kinase II are involved in platelet‐derived growth factor‐induced phosphorylation of Tiam1

1998 • 42 citations

Structural Basis for the Signaling Specificity of RhoG and Rac1 GTPases

2003 • 41 citations

GTPase Regulation Getting aRnd Rock and Rho Inhibition

2003 • 29 citations

Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac–GDP by its guanine nucleotide exchange factors

2001 • 25 citations