Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Polarized monolayers formed by epithelial cells on a permeable and translucent support

1978 • 869 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Tight junctions and the molecular basis for regulation of paracellular permeability

1995 • 825 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

Occludin is a functional component of the tight junction

1996 • 632 citations

The origin and characteristics of a pig kidney cell strain, LLC-PK1

1976 • 604 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

1997 • 576 citations

Occludin and claudins in tight-junction strands: leading or supporting players?

1999 • 575 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Structure, function, and regulation of cellular tight junctions

1992 • 517 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Protein Interactions at the Tight Junction

1999 • 470 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

Freeze-fracture replica electron microscopy combined with sds digestion for cytochemical labeling of integral membrane proteins: Application to the immunogold labeling of intercellular junctional complexes

1995 • 430 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Experimental modulation of occluding junctions in a cultured transporting epithelium.

1980 • 375 citations

Intestinal absorptive cell tight junctions are linked to cytoskeleton

1987 • 343 citations

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.

1995 • 337 citations

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

1996 • 329 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

Characterization of ZO-2 as a MAGUK Family Member Associated with Tight as well as Adherens Junctions with a Binding Affinity to Occludin and α Catenin

1999 • 302 citations

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

1997 • 301 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Phosphorylation of occludin correlates with occludin localization and function at the tight junction

1997 • 286 citations

Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 • 280 citations

Mammalian occludin in epithelial cells: its expression and subcellular distribution.

1997 • 278 citations

Restoration of Tight Junction Structure and Barrier Function by Down-Regulation of the Mitogen-activated Protein Kinase Pathway in Ras-transformed Madin-Darby Canine Kidney Cells

2000 • 271 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Regulated assembly of tight junctions by protein kinase C.

1995 • 262 citations

Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin

2000 • 229 citations

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

1994 • 228 citations

Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability.

1990 • 224 citations

Tight junction dynamics: Is paracellular transport regulated?

1988 • 213 citations

Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins

1999 • 196 citations

Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures

1996 • 193 citations

Tumor promoter-induced changes in the permeability of epithelial cell tight junctions

1981 • 185 citations

Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins

1980 • 182 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

Submembranous junctional plaque proteins include potential tumor suppressor molecules.

1993 • 179 citations

Redistribution and Phosphorylation of Occludin During Opening and Resealing of Tight Junctions in Cultured Epithelial Cells

1999 • 164 citations

Effects of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes

1986 • 163 citations

Functional coupling of tight junctions and microfilaments in T84 monolayers

1988 • 154 citations

Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion

1998 • 145 citations

Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes

1998 • 141 citations

Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ.

1994 • 133 citations

Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

1996 • 127 citations

Occludin 1B, a Variant of the Tight Junction Protein Occludin

2000 • 111 citations

Tumor Necrosis Factor-α Increases Sodium and Chloride Conductance Across the Tight Junction of CACO-2 BBE, a Human Intestinal Epithelial Cell Line

1998 • 108 citations

The Movement of Solutes and Cells across Tight Junctionsa

1992 • 106 citations

C. difficile toxin A increases intestinal permeability and induces Cl- secretion

1990 • 105 citations

Effect of reversible ATP depletion on tight-junction integrity in LLC-PK1 cells

1991 • 102 citations

The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells

1991 • 90 citations

Occludin dephosphorylation in early development of Xenopus laevis

1997 • 89 citations

Generation and maintenance of epithelial cell polarity

1990 • 76 citations

Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C

1993 • 75 citations

Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells

1995 • 68 citations

Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets

1997 • 66 citations

Effects of diacylglycerols on LLC‐PK₁ renal epithelia: Similarity to phorbol ester tumor promoters

1988 • 54 citations

Effects of Tyrosine Phosphorylation on Tight Junctions in Temperature-Sensitive v-src-transfected MDCK Cells.

1995 • 53 citations

Reversible disassembly of an intestinal epithelial monolayer by prolonged exposure to phorbol ester

1994 • 44 citations

Chronic Exposure of LLC-PK1Epithelia to the Phorbol Ester TPA Produces Polyp-like Foci with Leaky Tight Junctions and Altered Protein Kinase C-α Expression and Localization

1996 • 44 citations

Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-alpha

1997 • 33 citations

Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology

1992 • 30 citations

The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: comparison to phorbol esters

1990 • 19 citations

Electrophysiological Methods in the Study of Water Transport Across Cell Membranes

1991 • 3 citations