Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling

1980 • 574 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

A Regulatory Role for ARF6 in Receptor-Mediated Endocytosis

1995 • 451 citations

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

1990 • 443 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

1994 • 212 citations

Structure-function relationship of the small GTPase rab5.

1993 • 208 citations

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.

1994 • 190 citations

In vitro fusion of endosomes following receptor-mediated endocytosis.

1988 • 175 citations

Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells

1994 • 131 citations

Characterization of VPS34, a Gene Required for Vacuolar Protein Sorting and Vacuole Segregation in Saccharomyces cerevisiae†

1990 • 126 citations

Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae

1989 • 118 citations

Structural features of the GTP-binding defective Rab5 mutants required for their inhibitory activity on endocytosis.

1994 • 107 citations

Rab5, an early acting endosomal GTPase, supports in vitro endosome fusion without GTP hydrolysis.

1994 • 101 citations

Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes

1992 • 99 citations

Biochemical and Functional Characterization of a Recombinant GTPase, Rab5, and Two of Its Mutants

1995 • 54 citations

Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes.

1994 • 35 citations