Shear Stress-Mediated Cytoskeletal Remodeling and Cortactin Translocation in Pulmonary Endothelial Cells

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

1997 • 1,550 citations

The Function of Myosin and Myosin Light Chain Kinase Phosphorylation in Smooth Muscle

1985 • 1,052 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Activation of Arp2/3 complex-mediated actin polymerization by cortactin

2001 • 561 citations

Mechanotransduction in Response to Shear Stress

1999 • 560 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress

1996 • 503 citations

Fluid Shear Stress Activation of Focal Adhesion Kinase

1997 • 412 citations

Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex

2000 • 410 citations

Shear stress induces spatial reorganization of the endothelial cell cytoskeleton

1998 • 361 citations

An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

1999 • 355 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION

1997 • 319 citations

A Role for P21-Activated Kinase in Endothelial Cell Migration

1999 • 295 citations

The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells

1998 • 271 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

Transient and Steady-State Effects of Shear Stress on Endothelial Cell Adherens Junctions

1999 • 242 citations

Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro

1999 • 230 citations

Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction

2001 • 216 citations

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

1998 • 199 citations

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

1998 • 197 citations

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress

1999 • 185 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin.

1994 • 168 citations

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60^src

1999 • 157 citations

Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro

1998 • 152 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS

1999 • 150 citations

Endothelial Barrier Function under Laminar Fluid Shear Stress

2000 • 149 citations

Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase

2000 • 137 citations

Hemodynamics and Vascular Endothelial Biology

1993 • 128 citations

Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.

1999 • 126 citations

Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress

2001 • 121 citations

Role of c-Src tyrosine kinase in EGF-induced mitogenesis

1997 • 117 citations

Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle.

1993 • 109 citations

Temporal gradient in shear-induced signaling pathway: involvement of MAP kinase, c-fos, and connexin43

2000 • 103 citations

Spatial variations in endothelial barrier function in disturbed flows in vitro

2000 • 100 citations

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer

1997 • 99 citations

Src is required for cell migration and shape changes induced by fibroblast growth factor 1

1999 • 84 citations

An essential role of myosin light‐chain kinase in the regulation of agonist‐ and fluid flow‐stimulated Ca²⁺influx in endothelial cells

1998 • 78 citations

Lateral Zone of Cell-Cell Adhesion as the Major Fluid Shear Stress–Related Signal Transduction Site

2000 • 76 citations

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation

2000 • 76 citations

Shear-Induced Increase in Hydraulic Conductivity in Endothelial Cells Is Mediated by a Nitric Oxide–Dependent Mechanism

2000 • 75 citations

Quantitative Morphodynamics of Endothelial Cells within Confluent Cultures in Response to Fluid Shear Stress

2000 • 71 citations

Tyrosine Phosphorylation of Cortactin Is Required for H2O2-mediated Injury of Human Endothelial Cells

2000 • 60 citations

Hemodynamic‐Force‐Induced Difference of Interendothelial Junctional Complexes^a

1994 • 48 citations

Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction

2000 • 43 citations

Exposure to febrile temperature modifies endothelial cell response to tumor necrosis factor-α

2001 • 43 citations

A hemodynamic model representation of the dog lung

1991 • 36 citations

Alterations in wall tension and shear stress modulate tyrosine kinase signaling and wall remodeling in experimental vein grafts

1999 • 34 citations

Demonstration of actin filament stress fibers in microvascular endothelial cells in situ

1991 • 31 citations