Deciphering Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor Signaling to Vascular Permeability

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Natriuretic Peptides

1998 • 1,849 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

1997 • 1,162 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor

1989 • 996 citations

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

2001 • 960 citations

Physiological Role of Silent Receptors of Atrial Natriuretic Factor

1987 • 930 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

1999 • 802 citations

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

1999 • 653 citations

Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases

1989 • 579 citations

Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

1997 • 569 citations

Vascular reactions to histamine, histamine‐liberator and leukotaxine in the skin of guinea‐pigs

1952 • 535 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin

1998 • 506 citations

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src

1999 • 481 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Protein Interactions at the Tight Junction

1999 • 470 citations

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

2000 • 469 citations

Natriuretic peptide system in human heart failure.

1993 • 461 citations

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

1999 • 457 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

Vascular Endothelial Growth Factor–Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt

2000 • 413 citations

The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor

2001 • 370 citations

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

2001 • 336 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase

2000 • 314 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Vascular Endothelial Growth Factor Governs Endothelial Nitric-oxide Synthase Expression via a KDR/Flk-1 Receptor and a Protein Kinase C Signaling Pathway

1999 • 292 citations

Akt Down-regulation of p38 Signaling Provides a Novel Mechanism of Vascular Endothelial Growth Factor-mediated Cytoprotection in Endothelial Cells

2001 • 287 citations

Natriuretic Peptides Inhibit DNA Synthesis in Cardiac Fibroblasts

1995 • 278 citations

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

1998 • 271 citations

Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes.

1990 • 261 citations

Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases

1988 • 258 citations

Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation

1998 • 216 citations

Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells

2000 • 214 citations

H₂O₂-mediated permeability: role of MAPK and occludin

2000 • 213 citations

Vasoactive Peptides Modulate Vascular Endothelial Cell Growth Factor Production and Endothelial Cell Proliferation and Invasion

1997 • 205 citations

Protein Kinase C Regulates the Phosphorylation and Cellular Localization of Occludin

2001 • 199 citations

Estrogen Signals to the Preservation of Endothelial Cell Form and Function

2000 • 196 citations

Vascular endothelial growth factor

1993 • 191 citations

c-Src Is Required for Glial Cell Line-Derived Neurotrophic Factor (GDNF) Family Ligand-Mediated Neuronal Survival via a Phosphatidylinositol-3 Kinase (PI-3K)-Dependent Pathway

2001 • 171 citations

Identification of Tyrosine Residues in Vascular Endothelial Growth Factor Receptor-2/FLK-1 Involved in Activation of Phosphatidylinositol 3-Kinase and Cell Proliferation

2001 • 170 citations

Role of vascular endothelial cell growth factor in Ovarian Hyperstimulation Syndrome.

1998 • 165 citations

ATP depletion: a novel method to study junctional properties in epithelial tissues: cytoskeleton: I. Rearrangement of the actin

1994 • 157 citations

One hundred years of journal publication

1998 • 156 citations

Activation of Mitogen-activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP-dependent Protein Kinase in Contractile Vascular Smooth Muscle Cells

1999 • 138 citations

Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor-Induced Activation of the c-Jun N-Terminal Kinase Signaling Pathway

1997 • 133 citations

Atrial natriuretic polypeptide as a novel antigrowth factor of endothelial cells.

1992 • 131 citations

Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea‐fig, mouse and rat: many are transcellular pores

1997 • 120 citations

Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex.

1997 • 118 citations

A Mutant Form of Vascular Endothelial Growth Factor (VEGF) That Lacks VEGF Receptor-2 Activation Retains the Ability to Induce Vascular Permeability

1999 • 105 citations

Natriuretic Peptides Suppress Vascular Endothelial Cell Growth Factor Signaling to Angiogenesis*

2001 • 91 citations

Rac1 Protects Epithelial Cells against Anoikis

2001 • 90 citations

Nuclear Signaling by Endothelin-1 Requires Src Protein-tyrosine Kinases

1996 • 77 citations

Comparison of the function of the tight junctions of endothelial cells and epithelial cells in regulating the movement of electrolytes and macromolecules across the cell monolayer

1990 • 77 citations

The Role of Mitogen-Activated Protein Kinase Activation within Focal Adhesions in Chemotaxis toward FGF-2 by Murine Brain Capillary Endothelial Cells

2001 • 66 citations

Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor

2000 • 56 citations

Epidermal Growth Factor-induced Phosphatidylinositol 3-Kinase Activation and DNA Synthesis

2000 • 49 citations

Atrial natriuretic peptide inhibits endothelin-1-induced activation of JNK in glomerular mesangial cells

1998 • 42 citations

HS-142-1, a novel nonpeptide atrial natriuretic peptide (ANP) antagonist, blocks ANP-induced renal responses through a specific interaction with guanylyl cyclase-linked receptors

1992 • 42 citations