Tissue factor and angiogenesis in cancer

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Role of tissue factor in embryonic blood vessel development

1996 • 693 citations

In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease

1996 • 544 citations

Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy

2001 • 497 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

Cell biology of tissue factor, the principal initiator of blood coagulation

1996 • 418 citations

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.

1996 • 340 citations

Molecular Basis for the Relationship Between Thrombosis and Cancer

2001 • 336 citations

Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor

1999 • 316 citations

Targeted disruption of the murine tissue factor gene results in embryonic lethality

1996 • 277 citations

Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients With Solid Tumors

2002 • 253 citations

Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.

1998 • 249 citations

Protease-activated Receptors in Vascular Biology

2001 • 227 citations

Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice.

2001 • 223 citations

Structure and Biology of Tissue Factor Pathway Inhibitor

2001 • 217 citations

Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway.

1996 • 212 citations

Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor.

1994 • 203 citations

Vascular endothelial growth factor–stimulated endothelial cells promote adhesion and activation of platelets

2000 • 196 citations

Expression of tissue factor correlates with grade of malignancy in human glioma

1996 • 185 citations

Binding of Human Factor VIIa to Tissue Factor Induces Cytosolic Ca2+ Signals in J82 Cells, Transfected COS-1 Cells, Madin-Darby Canine Kidney Cells and in Human Endothelial Cells Induced to Synthesize Tissue Factor

1995 • 175 citations

Tissue factor expression in human colorectal carcinoma

2000 • 172 citations

Coagulation Factors VIIa and Xa Induce Cell Signaling Leading to Up-regulation of the egr-1 Gene

1999 • 164 citations

Signal Transduction via the Mitogen-activated Protein Kinase Pathway Induced by Binding of Coagulation Factor VIIa to Tissue Factor

1998 • 151 citations

Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: Correlation between tissue factor and angiogenesis

1998 • 141 citations

Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule

1999 • 129 citations

The Role of the Hemostatic System in Tumor Growth, Metastasis, and Angiogenesis: Tissue factor is a Bifunctional Molecule Capable of Inducing Both Fibrin Deposition and Angiogenesis in Cancer

2001 • 129 citations

Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family.

1996 • 125 citations

Tissue Factor – A Receptor Involved in the Control of Cellular Properties, Including Angiogenesis

2001 • 115 citations

Tissue factor de-encryption: ionophore treatment induces changes in tissue factor activity by phosphatidylserine-dependent and -independent mechanisms.

1999 • 113 citations

An Inhibitory Role of the Phosphatidylinositol 3-Kinase-signaling Pathway in Vascular Endothelial Growth Factor-induced Tissue Factor Expression

2001 • 112 citations

Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer

2001 • 108 citations

Cooperation Between VEGF and TNF-α Is Necessary for Exposure of Active Tissue Factor on the Surface of Human Endothelial Cells

1999 • 106 citations

Factor VIIa-induced p44/42 Mitogen-activated Protein Kinase Activation Requires the Proteolytic Activity of Factor VIIa and Is Independent of the Tissue Factor Cytoplasmic Domain

1999 • 104 citations

Fibrin activation of vascular endothelial cells. Induction of IL-8 expression.

1995 • 99 citations

Tissue factor de-encryption

1999 • 95 citations

Pathogenetic Mechanisms of Thrombosis in Malignancy

2001 • 95 citations

The Pleiotropic Effects of Tissue Factor: a Possible Role for Factor VIIa-induced Intracellular Signalling?

2001 • 87 citations

Platelets and Cancer: Implications for Antiangiogenic Therapy

2002 • 86 citations

Vascular Endothelial Growth Factor Production by Fibroblasts in Response to Factor VIIa Binding to Tissue Factor Involves Thrombin and Factor Xa

2000 • 83 citations

Thrombosis in cancer patients

2000 • 83 citations

Caveolae--Not Just Craters in the Cellular Landscape

2001 • 80 citations

Expression of tissue factor pathway inhibitor 2 inversely correlates during the progression of human gliomas.

2001 • 65 citations

Pancreatic cancer complicated by disseminated intravascular coagulation associated with production of tissue factor

2001 • 49 citations

Elevated plasma levels of the factor Xa–TFPI complex in cancer patients

2002 • 46 citations

Molecular Mechanisms Linking Thrombosis and Angiogenesis in Cancer

1997 • 45 citations

Cellular Consequences upon Factor VIIa Binding to Tissue Factor

2000 • 45 citations

Bioactivity of the Vascular Endothelial Growth Factor Trapped in Fibrin Clots: Production of IL-6 and IL-8 in Monocytes by Fibrin Clots

2001 • 41 citations

Role of tissue factor pathway inhibitor-2 (TFPI-2) in amelanotic melanoma (C-32) invasion.

2000 • 40 citations

Cell Biology of Tissue Factor, an Unusual Member of the Cytokine Receptor Family

2001 • 38 citations

Fibrin induction of tissue factor expression in human vascular endothelial cells.

1997 • 37 citations

The biology and tumour-related properties of monocyte tissue factor

2001 • 36 citations

Manifestation of cryptic fibroblast tissue factor occurs at detergent concentrations which dissolve the plasma membrane

1996 • 31 citations

The blood platelet as a model for regulating blood coagulation on cell surfaces and its consequences.

2002 • 25 citations

Tissue Factor Encryption/de-encryption Is not Altered in the Absence of the Cytoplasmic Domain

2000 • 23 citations

Quantitative Reverse Transcription-PCR Measurement of Tissue Factor mRNA in Glioma

2002 • 17 citations

Tissue factor expression and multidrug resistance in cancer: two aspects of a common cellular response to a hostile milieu

2000 • 16 citations

Cellular Effects of Initiation of the Extrinsic Pathway of Blood Coagulation

2000 • 15 citations

Untitled

2000 • 9 citations