GIT1 Mediates Thrombin Signaling in Endothelial Cells

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

FAK integrates growth-factor and integrin signals to promote cell migration

2000 • 1,215 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

Exploring the Neighborhood

2002 • 398 citations

Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation

2001 • 386 citations

Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 • 353 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

2001 • 309 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.

1996 • 206 citations

Isolation and Contraction of the Stress Fiber

1998 • 203 citations

Fluid Shear Stress Stimulates Big Mitogen-activated Protein Kinase 1 (BMK1) Activity in Endothelial Cells

1999 • 179 citations

Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction

2000 • 172 citations

Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System

2001 • 155 citations

Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin

1996 • 152 citations

Simvastatin Improves Disturbed Endothelial Barrier Function

2000 • 147 citations

S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin

2003 • 143 citations

Opposing Effects of Reactive Oxygen Species and Cholesterol on Endothelial Nitric Oxide Synthase and Endothelial Cell Caveolae

1999 • 141 citations

Involvement of site‐specific FAK phosphorylation in sphingosine‐1 phosphate‐ and thrombin‐induced focal adhesion remodeling: role of Src and GIT

2003 • 130 citations

ROCK mediates thrombin's endothelial barrier dysfunction

2000 • 127 citations

Shear Stress Stimulation of p130 Tyrosine Phosphorylation Requires Calcium-dependent c-Src Activation

1999 • 112 citations

Gα12 and Gα13 Stimulate Rho-dependent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and p130 Crk-associated Substrate

1998 • 110 citations

An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization

2001 • 91 citations

GIT1 Functions as a Scaffold for MEK1–Extracellular Signal-Regulated Kinase 1 and 2 Activation by Angiotensin II and Epidermal Growth Factor

2003 • 90 citations

Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site.

2000 • 90 citations

A New Monoclonal Antibody Which Selectively Recognizes the Active Form of Src Tyrosine Kinase

1996 • 87 citations

Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function

2002 • 85 citations

GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor

2003 • 82 citations

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

1997 • 76 citations

Tyrosine Kinases of the Src Family Participate in Signaling to MAP Kinase from both Gqand Gi-Coupled Receptors

1998 • 74 citations

Tyrosine Phosphorylation of Cortactin Is Required for H2O2-mediated Injury of Human Endothelial Cells

2000 • 60 citations

Why do so many stimuli induce tyrosine phosphorylation of FAK?

1999 • 50 citations

Roles for the tubulin- and PTP–PEST-binding paxillin LIM domains in cell adhesion and motility

2002 • 40 citations

Angiotensin II Stimulates Tyrosine Phosphorylation of Phospholipase C-γ–Associated Proteins

1997 • 32 citations