Regulation of Gap Junctions by Phosphorylation of Connexins

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

The Gap Junction Communication Channel

1996 • 1,896 citations

14-3-3 Proteins: Structure, Function, and Regulation

2000 • 1,552 citations

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

1997 • 1,435 citations

Cardiac Malformation in Neonatal Mice Lacking Connexin43

1995 • 1,242 citations

CONNEXINS, CONNEXONS, AND INTERCELLULAR COMMUNICATION

1996 • 1,180 citations

Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease

1993 • 1,055 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Molecular cloning of cDNA for rat liver gap junction protein.

1986 • 715 citations

Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques.

1991 • 705 citations

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.

1990 • 697 citations

Connexin family of gap junction proteins

1990 • 553 citations

Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication

2000 • 533 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER

1993 • 492 citations

Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes

1991 • 469 citations

Rapid Turnover of Connexin43 in the Adult Rat Heart

1998 • 425 citations

Disruption of α3 Connexin Gene Leads to Proteolysis and Cataractogenesis in Mice

1997 • 415 citations

Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

1995 • 376 citations

cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.

1986 • 374 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block

1998 • 363 citations

Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation

1990 • 358 citations

Targeted Ablation of Connexin50 in Mice Results in Microphthalmia and Zonular Pulverulent Cataracts

1998 • 354 citations

Phosphorylation of Connexin43 Gap Junction Protein in Uninfected and Rous Sarcoma Virus-Transformed Mammalian Fibroblasts

1990 • 352 citations

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies.

1992 • 351 citations

Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes.

1989 • 341 citations

Form and Function in Protein Dephosphorylation

1996 • 334 citations

Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase

1998 • 330 citations

Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells.

1996 • 327 citations

Gap Junctions: Their Presence and Necessity in Myometrium During Parturition

1977 • 323 citations

Structure-activity relations of the cardiac gap junction channel

1990 • 312 citations

Physiological Role of Gap-Junctional Hemichannels

2000 • 305 citations

Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein

1996 • 282 citations

Transplacental Uptake of Glucose Is Decreased in Embryonic Lethal Connexin26-deficient Mice

1998 • 280 citations

Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

1990 • 276 citations

Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells.

1995 • 263 citations

Intramolecular interactions mediate pH regulation of connexin43 channels

1996 • 263 citations

Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts.

1990 • 262 citations

Modulation of gap junction transcript and protein expression during pregnancy in the rat.

1990 • 259 citations

Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

1994 • 254 citations

Degradation of Connexin43 Gap Junctions Involves both the Proteasome and the Lysosome

1997 • 252 citations

Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly.

1994 • 214 citations

Trafficking, Assembly, and Function of a Connexin43-Green Fluorescent Protein Chimera in Live Mammalian Cells

1999 • 204 citations

The Pattern of Disulfide Linkages in the Extracellular Loop Regions of Connexin 32 Suggests a Model for the Docking Interface of Gap Junctions

1998 • 202 citations

Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine.

1992 • 192 citations

Phosphorylation of connexin 32, a hepatocyte gap‐junction protein, by cAMP‐dependent protein kinase, protein kinase C and Ca²⁺/calmodulin‐dependent protein kinase II

1990 • 188 citations

Tyrosine Phosphorylation of Connexin 43 by v-Src Is Mediated by SH2 and SH3 Domain Interactions

1997 • 187 citations

Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.

1993 • 174 citations

The Cellular src Gene Product Regulates Junctional Cell-to-Cell Communication

1988 • 169 citations

Gap-junction disassembly and connexin 43 dephosphorylation induced by 18β-glycyrrhetinic acid

1996 • 169 citations

Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.

1995 • 168 citations

Functional and Structural Assessment of Intercellular Communication

1996 • 167 citations

Kinetics of Steady-state Currents and Charge Movements Associated with the Rat Na+/Glucose Cotransporter

1995 • 166 citations

Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio.

1993 • 164 citations

Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcoma virus.

1981 • 164 citations

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins.

1991 • 162 citations

Cell-free synthesis and assembly of connexins into functional gap junction membrane channels

1997 • 161 citations

Functional analysis of human cardiac gap junction channel mutants.

1991 • 160 citations

The role of gap junction membrane channels in development

1996 • 158 citations

Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin 43 Gap Junction Channels

1999 • 157 citations

Phosphorylation of Connexin43 and the Regulation of Neonatal Rat Cardiac Myocyte Gap Junctions

1997 • 156 citations

Cyclic adenosine monophosphate stimulates biosynthesis and phosphorylation of the 26 kDa gap junction protein in cultured mouse hepatocytes.

1987 • 152 citations

pp60 -mediated Phosphorylation of Connexin 43, a Gap Junction Protein

1995 • 142 citations

Connexin43 in MDCK cells: regulation by a tumor-promoting phorbol ester and Ca2+.

1992 • 141 citations

Synthesis, assembly and structure of gap junction intercellular channels

1998 • 141 citations

TPA Increases Conductance but Decreases Permeability in Neonatal Rat Cardiomyocyte Gap Junction Channels

1995 • 139 citations

Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase

1998 • 132 citations

Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs.

1992 • 131 citations

Altered junctional permeability between cells transformed by v-ras, v-mos, or v-src

1988 • 128 citations

Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells.

1992 • 124 citations

Growth factors modulate junctional cell-to-cell communication

1988 • 119 citations

Tissue-specific distribution of differentially phosphorylated forms of Cx43.

1991 • 117 citations

Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.

1998 • 114 citations

Gating Connexin 43 Channels Reconstituted in Lipid Vesicles by Mitogen-activated Protein Kinase Phosphorylation

1999 • 111 citations

Cell interactions and gap junctions

1989 • 107 citations

Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation

2000 • 106 citations

Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition

2000 • 103 citations

Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes.

1992 • 102 citations

Regulation of gap junctions by protein phosphorylation

1998 • 101 citations

Cyclic AMP induces rapid increases in gap junction permeability and changes in the cellular distribution of connexin43

1995 • 98 citations

Decreased incidence of gap junctions between Chinese hamster V-79 cells upon exposure to the tumor promoter 12--tetradecanoyl phorbol-13-acetate

1982 • 97 citations

A Mitosis-specific Phosphorylation of the Gap Junction Protein Connexin43 in Human Vascular Cells: Biochemical Characterization and Localization

1997 • 97 citations

Characterization of gap junctions between cultured leptomeningeal cells

1991 • 91 citations

Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells

1994 • 91 citations

Assembly of heteromeric connexons in guinea‐pig liver en route to the Golgi apparatus, plasma membrane and gap junctions

1999 • 91 citations

Topography of connexin32 in rat liver gap junctions : Evidence for an intramolecular disulphide linkage connecting the two extracellular peptide loops

1991 • 90 citations

Cyclic AMP modifies the cellular distribution of connexin43 and induces a persistent increase in the junctional permeability of mouse mammary tumor cells

1995 • 87 citations

Molecular mechanisms of TPA‐mediated inhibition of Gap‐junctional intercellular communication: Evidence for action on the assembly or function but not the expression of connexin 43 in rat liver epithelial cells

1991 • 83 citations

Assembly of hepatic gap junctions. Topography and distribution of connexin 32 in intracellular and plasma membranes determined using sequence-specific antibodies.

1993 • 83 citations

Platelet-derived growth factor-induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen-activated protein kinase

1998 • 80 citations

An activator of protein kinase C inhibits gap junction communication between cultured bovine lens cells

1992 • 78 citations

Gating properties of connexin32 cell—cell channels and their mutants expressed in Xenopus oocytes

1991 • 77 citations

Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor

1998 • 77 citations

Myometrial connexin 43 trafficking and gap junction assembly at term and in preterm labor

1992 • 76 citations

Membrane integration of in vitro-translated gap junctional proteins: co- and post-translational mechanisms.

1996 • 76 citations

Trapping an Intermediate Form of Connexin43 in the Golgi

1993 • 75 citations

Reduced cell-cell communication between mitotic and nonmitotic coupled cells

1992 • 70 citations

p130gag-fps disrupts gap junctional communication and induces phosphorylation of connexin43 in a manner similar to that of pp60v-src.

1994 • 70 citations

A connexin‐32 mutation associated with Charcot‐Marie‐Tooth disease does not affect channel formation in oocytes

1994 • 69 citations

Characterization of the gap junction protein, connexin45

1994 • 67 citations

Phosphorylated Carboxy Terminal Serine Residues Stabilize the Mouse Gap Junction Protein Connexin45 Against Degradation

1998 • 67 citations

Immunolocalization and expression of functional and nonfunctional cell-to-cell channels from wild-type and mutant rat heart connexin43 cDNA.

1992 • 65 citations

Analysis of Connexin Phosphorylation Sites

2000 • 61 citations

Connexon integrity is maintained by non-covalent bonds: Intramolecular disulfide bonds link the extracellular domains in rat connexin-43

1991 • 60 citations

Disruption of Gap Junctional Communication by the Platelet-derived Growth Factor Is Mediated via Multiple Signaling Pathways

1999 • 60 citations

Mitogen-activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet-derived growth factor and tetradecanoylphorbol acetate

1999 • 56 citations

Effects of phorbol ester on gap junctions of neonatal rat heart cells

1993 • 55 citations

The Gap‐Junction Protein Connexin 56 is Phosphorylated in the Intracellular Loop and the Carboxy‐Terminal Region

1997 • 54 citations

Mechanisms of plasma membrane protein degradation: recycling proteins are degraded more rapidly than those confined to the cell surface.

1991 • 52 citations

In vivo association of pp60v-src and the gap-junction protein connexin 43 in v-src-transformed fibroblasts

1999 • 50 citations

Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells

1999 • 49 citations

Role of Cx43 Phosphorylation and MAP Kinase Activation in EGF Induced Enhancement of Cell Communication in Human Kidney Epithelial Cells

1998 • 42 citations

cAMP promotes gap junctional coupling in T84 cells

1996 • 41 citations

Phosphatase inhibitors, gap junctional intercellular communication and [¹²⁵l)-EGF binding in hamster fibroblasts

1993 • 38 citations

The epidermal growth factor receptor tyrosine kinase phosphorylates connexin32.

1998 • 34 citations

Phosphatases Involved in Modulation of Gap Junctional Intercellular Communication and Dephosphorylation of Connexin43 in Hamster Fibroblasts: 2B or Not 2B?

1999 • 33 citations

Inhibition of Glycosylation Induces Formation of Open Connexin-43 Cell-to-Cell Channels and Phosphorylation and Triton X-100 Insolubility of Connexin-43

1995 • 30 citations

Immunolocalization of an extracellular domain of connexin43 in rat heart gap junctions.

1991 • 20 citations

Effects of cigarette smoke condensate and 12-0-tetradecanoylphorbol-13-acetage on gap junction structure and function in cultured cells

1990 • 18 citations

Effects of five phorbal esters on gap junctional lintercellular communication, morphological transformation and epidermal growth factor binding in Syrian hamster embryo cells

1993 • 13 citations