Activation of NF-κB induced by H2O2and TNF-α and its effects on ICAM-1 expression in endothelial cells
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[1] Role of free radicals and catalytic metal ions in human disease: An overview
1990 • 5,041 citations
Function and Activation of NF-kappaB in the Immune System
1994 • 4,698 citations
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
1997 • 4,661 citations
NF-κB: Ten Years After
1996 • 3,008 citations
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
1986 • 2,490 citations
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
1997 • 2,137 citations
Structure, Regulation and Function of NF-kappaB
1994 • 2,110 citations
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation
1997 • 1,802 citations
Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)
1992 • 1,421 citations
HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line
1992 • 1,258 citations
Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300
1998 • 1,200 citations
Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.
1989 • 1,115 citations
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.
1995 • 1,010 citations
Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families
1988 • 967 citations
Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity
1996 • 960 citations
[71] Use of eukaryotic expression technology in the functional analysis of cloned genes
1987 • 834 citations
Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62
1992 • 825 citations
The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism
1997 • 820 citations
CREB-binding protein/p300 are transcriptional coactivators of p65
1997 • 819 citations
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.
1992 • 731 citations
Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator
1997 • 725 citations
p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor
1998 • 678 citations
Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.
1988 • 626 citations
Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system
1993 • 541 citations
Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells
1995 • 540 citations
Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes
1995 • 538 citations
The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB
1995 • 460 citations
The inducible transcription factor NF-κB: structure-function relationship of its protein subunits
1993 • 429 citations
Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529
1998 • 375 citations
Elevated Cyclic AMP Inhibits NF-κB-mediated Transcription in Human Monocytic Cells and Endothelial Cells
1996 • 341 citations
A new approach for measurement of cytotoxicity using colorimetric assay
1993 • 322 citations
H2O2 and Tumor Necrosis Factor-α Activate Intercellular Adhesion Molecule 1 (ICAM-1) Gene Transcription through Distinct cis-Regulatory Elements within the ICAM-1 Promoter
1995 • 284 citations
Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.
1998 • 278 citations
Oxygen and the control of gene expression
1994 • 245 citations
H2O2 and Tumor Necrosis Factor-α Induce Differential Binding of the Redox-responsive Transcription Factors AP-1 and NF-κB to the Interleukin-8 Promoter in Endothelial and Epithelial Cells
1998 • 224 citations
Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.
1994 • 217 citations
Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit
1997 • 208 citations
Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells
1999 • 192 citations
E-selectin expression in human endothelial cells by TNF-α-induced oxidant generation and NF-κB activation
1998 • 171 citations
Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells.
1993 • 170 citations
Transactivation Domain 2 (TA2) of p65 NF-κB
1995 • 161 citations
Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.
1999 • 159 citations
Differential Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 by H2O2 and Tumor Necrosis Factor-α in Endothelial and Epithelial Cells
1997 • 156 citations
Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.
1993 • 142 citations
Thrombin-Induced p65 Homodimer Binding to Downstream NF-κB Site of the Promoter Mediates Endothelial ICAM-1 Expression and Neutrophil Adhesion
1999 • 132 citations
Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells
1995 • 113 citations
Transcriptional up-regulation of intracellular adhesion molecule-1 in human endothelial cells by the antioxidant pyrrolidine dithiocarbamate involves the activation of activating protein-1.
1996 • 85 citations
Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription.
1999 • 72 citations
Carbonatite origin and diversity
1989 • 7 citations
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