Regulation of Endothelial Barrier Function by the cAMP-Dependent Protein Kinase

Biostatistical Analysis (2nd ed.).

1986 • 5,963 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

LABORATORY INVESTIGATION

1956 • 1,491 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Role of endothelial cell cytoskeleton in control of endothelial permeability.

1982 • 310 citations

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells

1997 • 285 citations

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1989 • 251 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

A Protein Kinase Inhibitor Gene Reduces Both Basal and Multihormone-stimulated Prolactin Gene Transcription

1989 • 203 citations

Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels

1992 • 197 citations

Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium.

1990 • 196 citations

Towards an Understanding of the Mechanism of Action of Cyclic AMP and Cyclic GMP in Smooth Muscle Relaxation

1991 • 191 citations

Role of phosphodiesterases in the regulation of endothelial permeability in vitro.

1993 • 189 citations

Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase.

1984 • 176 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Myosin light chain kinase phosphorylation in tracheal smooth muscle.

1990 • 171 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin

1996 • 152 citations

Expression of PKA inhibitor (PKI) gene abolishes cAMPmediated protection to endothelial barrier dysfunction

1999 • 141 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

Structure and function of the endothelial cytoskeleton.

1991 • 136 citations

Actin—membrane interaction in focal adhesions

1990 • 130 citations

The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells.

1993 • 122 citations

Endothelial cell monolayer integrity. I. Characterization of dense peripheral band of microfilaments.

1986 • 119 citations

Role of myosin light-chain phosphorylation in endothelial cell retraction

1993 • 117 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

Control of repetitive electrical discharges by means of an external electrode

1992 • 111 citations

TNF modulates endothelial properties by decreasing cAMP

1995 • 111 citations

Biochemical Regulation of the Nonmuscle Myosin Light Chain Kinase Isoform in Bovine Endothelium

1998 • 105 citations

Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vitro

1988 • 102 citations

Vascular endothelial cell activation and permeability responses to thrombin

1995 • 98 citations

Mechanisms of ionomycin-induced endothelial cell barrier dysfunction

1997 • 98 citations

An N‐cadherin–like protein contributes to solute barrier maintenance in cultured endothelium

1993 • 92 citations

Effects of calcium on transendothelial albumin transfer and electrical resistance

1986 • 91 citations

Calcium as Intracellular Messenger: From Simplicity to Complexity

1990 • 85 citations

Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.

1995 • 83 citations

Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP.

1990 • 78 citations

Mechanisms of Cholera Toxin Prevention of Thrombin- and PMA-Induced Endothelial Cell Barrier Dysfunction

1994 • 78 citations

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

1997 • 76 citations

Pharmacological modification of pulmonary vascular injury: possible role of cAMP

1987 • 72 citations

Time course of thrombin-induced increase in endothelial permeability: relationship to Ca2+i and inositol polyphosphates

1992 • 66 citations

Cyclic AMP relaxes swine arterial smooth muscle predominantly by decreasing cell Ca2+ concentration.

1991 • 59 citations

The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase

1991 • 52 citations

Endothelial monolayer integrity. Perturbation of F-actin filaments and the dense peripheral band-vinculin network.

1990 • 49 citations

Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep

1987 • 33 citations

Actomyosin organization in stationary and migrating sheets of cultured human endothelial cells

1985 • 29 citations

The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein

1997 • 24 citations

Regulation of thrombin-induced endothelial cell activation by bacterial toxins

1994 • 23 citations

Phosphorylation of H-ras Proteins by Protein Kinase A

1997 • 9 citations

Molecular Organization of Endothelial Cell to Cell Junctions

1996 • 6 citations