Idiopathic pulmonary fibrosis

Epithelial-Mesenchymal Transitions in Development and Disease

2009 • 9,228 citations

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

2011 • 6,482 citations

Cutaneous Wound Healing

1999 • 5,878 citations

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

2002 • 5,594 citations

Cancer Statistics, 2006

2006 • 5,351 citations

American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias

2002 • 3,947 citations

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Bosentan Therapy for Pulmonary Arterial Hypertension

2002 • 2,715 citations

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

2001 • 2,653 citations

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000 • 2,535 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

2011 • 1,890 citations

Evidence that fibroblasts derive from epithelium during tissue fibrosis

2002 • 1,792 citations

Inhaled Iloprost for Severe Pulmonary Hypertension

2002 • 1,760 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Fibrotic disease and the TH1/TH2 paradigm

2004 • 1,623 citations

Prevention of Radiographic-Contrast-Agent–Induced Reductions in Renal Function by Acetylcysteine

2000 • 1,589 citations

The myofibroblast in wound healing and fibrocontractive diseases

2003 • 1,548 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects

2003 • 1,405 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

The Measurement of Dyspnea

1984 • 1,291 citations

Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial

2002 • 1,272 citations

Idiopathic Pulmonary Fibrosis

1998 • 1,255 citations

Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

2007 • 1,249 citations

Incidence and Prevalence of Idiopathic Pulmonary Fibrosis

2006 • 1,240 citations

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

2006 • 1,197 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

Tissue-Engineered Lungs for in Vivo Implantation

2010 • 1,141 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Spirometric Standards for Healthy Nonsmoking Adults

1971 • 1,096 citations

Acute Exacerbations of Idiopathic Pulmonary Fibrosis

2007 • 1,067 citations

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

2011 • 1,038 citations

Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis

1998 • 1,037 citations

Reversal of experimental pulmonary hypertension by PDGF inhibition

2005 • 1,018 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Idiopathic Pulmonary Fibrosis

2001 • 956 citations

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

2004 • 953 citations

Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity

2005 • 933 citations

High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis

2005 • 927 citations

Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

2005 • 923 citations

Induction of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells by Transforming Growth Factor-β1

2005 • 918 citations

The epidemiology of interstitial lung diseases.

1994 • 912 citations

Echocardiographic Assessment of Pulmonary Hypertension in Patients with Advanced Lung Disease

2003 • 890 citations

Perspective Article: Tissue repair, contraction, and the myofibroblast

2005 • 849 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Prevalence and Outcomes of Pulmonary Arterial Hypertension in Advanced Idiopathic Pulmonary Fibrosis

2006 • 828 citations

Treatment of Asthma with Drugs Modifying the Leukotriene Pathway

1999 • 825 citations

Predicting Survival in Idiopathic Pulmonary Fibrosis

2001 • 822 citations

Natural History and Treated Course of Usual and Desquamative Interstitial Pneumonia

1978 • 802 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Histopathologic Subsets of Fibrosing Alveolitis in Patients with Systemic Sclerosis and Their Relationship to Outcome

2002 • 784 citations

Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

2001 • 768 citations

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

2002 • 763 citations

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

2015 • 746 citations

Nonspecific Interstitial Pneumonia/Fibrosis

1994 • 742 citations

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

2008 • 726 citations

Changes in Clinical and Physiologic Variables Predict Survival in Idiopathic Pulmonary Fibrosis

2003 • 721 citations

Mechanisms of Pulmonary Fibrosis

2004 • 714 citations

Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis.

1997 • 707 citations

Idiopathic Pulmonary Fibrosis

1976 • 706 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 696 citations

TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

2005 • 695 citations

BUILD-3: A Randomized, Controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis

2011 • 690 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Epithelial repair mechanisms in the lung

2010 • 662 citations

Histopathologic Variability in Usual and Nonspecific Interstitial Pneumonias

2001 • 652 citations

Bone marrow–derived progenitor cells in pulmonary fibrosis

2004 • 649 citations

A Placebo-Controlled Trial of Interferon Gamma-1b in Patients with Idiopathic Pulmonary Fibrosis

2004 • 643 citations

Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial

2002 • 639 citations

Heterozygosity for a Surfactant Protein C Gene Mutation Associated with Usual Interstitial Pneumonitis and Cellular Nonspecific Interstitial Pneumonitis in One Kindred

2002 • 635 citations

Idiopathic Pulmonary Fibrosis

2001 • 628 citations

Idiopathic Interstitial Pneumonia

2004 • 625 citations

Idiopathic Pulmonary Fibrosis

2003 • 615 citations

High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis

2005 • 608 citations

Lung Cancer and Cryptogenic Fibrosing Alveolitis

2000 • 606 citations

Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation

2001 • 605 citations

The Clinical Course of Patients with Idiopathic Pulmonary Fibrosis

2005 • 601 citations

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

2002 • 600 citations

Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11

2014 • 594 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Myofibroblast Differentiation by Transforming Growth Factor-ॆ1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase

2003 • 574 citations

Prognosis of Fibrotic Interstitial Pneumonia

2007 • 566 citations

Fibrotic Idiopathic Interstitial Pneumonia

2003 • 562 citations

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

1996 • 559 citations

Bone marrow-derived cells as progenitors of lung alveolar epithelium

2001 • 555 citations

Utility of a Lung Biopsy for the Diagnosis of Idiopathic Pulmonary Fibrosis

2001 • 553 citations

Lung volumes in healthy nonsmoking adults.

1982 • 553 citations

Increased Prevalence of Gastroesophageal Reflux in Patients with Idiopathic Pulmonary Fibrosis

1998 • 547 citations

Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK

2006 • 547 citations

Radiological versus histological diagnosis in UIP and NSIP: survival implications

2003 • 539 citations

Leukotriene E4 and granulocytic infiltration into asthmatic airways

1993 • 537 citations

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

1999 • 532 citations

Cryptogenic fibrosing alveolitis: clinical features and their influence on survival

1980 • 529 citations

Idiopathic Nonspecific Interstitial Pneumonia: Prognostic Significance of Cellular and Fibrosing Patterns

2000 • 527 citations

Circulating fibrocytes: collagen-secreting cells of the peripheral blood

2003 • 526 citations

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

2004 • 524 citations

Prognostic Value of Desaturation during a 6-Minute Walk Test in Idiopathic Interstitial Pneumonia

2003 • 514 citations

Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis

2008 • 514 citations

INTERNATIONAL GUIDELINES FOR THE SELECTION OF LUNG TRANSPLANT CANDIDATES

1998 • 511 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

Upregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD

2000 • 508 citations

Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial

2009 • 508 citations

Prognostic Implications of Physiologic and Radiographic Changes in Idiopathic Interstitial Pneumonia

2003 • 507 citations

High-Resolution Computed Tomography in Idiopathic Pulmonary Fibrosis

2005 • 502 citations

Standardized single breath normal values for carbon monoxide diffusing capacity.

1981 • 499 citations

The Myofibroblast in Pulmonary Fibrosis*

2002 • 498 citations

The Prognostic Significance of the Histologic Pattern of Interstitial Pneumonia in Patients Presenting with the Clinical Entity of Cryptogenic Fibrosing Alveolitis

2000 • 492 citations

Interleukin-1β and Tumor Necrosis Factor-α Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts In Vitro

2000 • 486 citations

Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features

2005 • 484 citations

Alveolar Cell Senescence in Patients with Pulmonary Emphysema

2006 • 481 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth Official Adult Lung and Heart–Lung Transplantation Report—2007

2007 • 470 citations

An Immunohistochemical Study of Architectural Remodeling and Connective Tissue Synthesis in Pulmonary Fibrosis

1989 • 469 citations

Treatment of Idiopathic Pulmonary Fibrosis with a New Antifibrotic Agent, Pirfenidone

1999 • 465 citations

Incidence, Prevalence, and Clinical Course of Idiopathic Pulmonary Fibrosis

2009 • 464 citations

The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts

1999 • 462 citations

Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.

1990 • 462 citations

The rising incidence of idiopathic pulmonary fibrosis in the UK

2011 • 457 citations

Acute Exacerbation in Idiopathic Pulmonary Fibrosis

1993 • 450 citations

Thin-section CT obtained at 10-mm increments versus limited three-level thin-section CT for idiopathic pulmonary fibrosis: correlation with pathologic scoring.

1997 • 440 citations

Anticoagulant Therapy for Idiopathic Pulmonary Fibrosis

2005 • 440 citations

Idiopathic Pulmonary Fibrosis and Emphysema

2009 • 437 citations

Mechanisms for pro matrix metalloproteinase activation

1999 • 436 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Chronic diffuse infiltrative lung disease: comparison of diagnostic accuracy of CT and chest radiography.

1989 • 422 citations

CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury

2005 • 422 citations

Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors

2002 • 422 citations

Azathioprine Combined with Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis: A Prospective Double-blind, Randomized, Placebo-controlled Clinical Trial

1991 • 416 citations

Classification and Natural History of the Idiopathic Interstitial Pneumonias

2006 • 416 citations

Mortality from Pulmonary Fibrosis Increased in the United States from 1992 to 2003

2007 • 414 citations

TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

2000 • 412 citations

Oxidative Stress in Pulmonary Fibrosis

2005 • 410 citations

The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.

1991 • 406 citations

Clinical and Pathologic Features of Familial Interstitial Pneumonia

2005 • 406 citations

Pulmonary Hypertension in Patients With Idiopathic Pulmonary Fibrosis

2005 • 404 citations

Idiopathic Pulmonary Fibrosis

1998 • 404 citations

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats

1998 • 402 citations

The Accuracy of the Clinical Diagnosis of New-Onset Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Disease

1999 • 402 citations

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

2008 • 401 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Inhaled Prostacyclin and Iloprost in Severe Pulmonary Hypertension Secondary to Lung Fibrosis

1999 • 399 citations

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

1998 • 395 citations

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

2001 • 395 citations

A Histologic Pattern of Nonspecific Interstitial Pneumonia Is Associated with a Better Prognosis Than Usual Interstitial Pneumonia in Patients with Cryptogenic Fibrosing Alveolitis

1999 • 388 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Six-Minute-Walk Distance Predicts Waiting List Survival in Idiopathic Pulmonary Fibrosis

2006 • 382 citations

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

1997 • 380 citations

Angiotensin II Blockade Reverses Myocardial Fibrosis in a Transgenic Mouse Model of Human Hypertrophic Cardiomyopathy

2001 • 377 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Clinical significance of histological classification of idiopathic interstitial pneumonia

2002 • 371 citations

CT Features of Lung Disease in Patients with Systemic Sclerosis: Comparison with Idiopathic Pulmonary Fibrosis and Nonspecific Interstitial Pneumonia

2004 • 370 citations

Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis

2004 • 367 citations

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

1995 • 364 citations

Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling

2001 • 360 citations

Idiopathic Pulmonary Fibrosis

2006 • 360 citations

Idiopathic Nonspecific Interstitial Pneumonia

2007 • 359 citations

Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis

2005 • 359 citations

Is Idiopathic Pulmonary Fibrosis an Environmental Disease?

2006 • 357 citations

International Guidelines for the Selection of Lung Transplant Candidates

1998 • 357 citations

Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder

2001 • 356 citations

Idiopathic Interstitial Pneumonias: Diagnostic Accuracy of Thin-Section CT in 129 Patients

1999 • 355 citations

The role of PTEN signaling perturbations in cancer and in targeted therapy

2008 • 354 citations

Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

1999 • 354 citations

Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.

1994 • 353 citations

Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis

2004 • 352 citations

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

2008 • 351 citations

Cryptogenic fibrosing alveolitis and lung cancer.

1980 • 351 citations

Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts

2004 • 351 citations

Angiotensin II Stimulated Expression of Transforming Growth Factor-β1in Cardiac Fibroblasts and Myofibroblasts

1997 • 350 citations

Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression

2001 • 348 citations

Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.

1987 • 348 citations

Occupational and Environmental Risk Factors for Idiopathic Pulmonary Fibrosis: A Multicenter Case-Control Study

2000 • 346 citations

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis

1999 • 344 citations

Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β₁

1999 • 343 citations

Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.

1996 • 343 citations

Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy

2001 • 341 citations

Computed Tomography Findings in Pathological Usual Interstitial Pneumonia

2007 • 338 citations

Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP

1998 • 336 citations

p38 MAP kinase: a convergence point in cancer therapy

2004 • 334 citations

Determinants of survival in idiopathic pulmonary fibrosis.

1994 • 333 citations

Focal Adhesion Kinase Is Upstream of Phosphatidylinositol 3-Kinase/Akt in Regulating Fibroblast Survival in Response to Contraction of Type I Collagen Matrices via a β1 Integrin Viability Signaling Pathway

2004 • 333 citations

Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure.

1993 • 329 citations

P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis.

1996 • 329 citations

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

1996 • 326 citations

Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts.

1990 • 320 citations

<scp>D</scp>-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma)

1982 • 317 citations

Radiologic Findings Are Strongly Associated With a Pathologic Diagnosis of Usual Interstitial Pneumonia

2003 • 316 citations

Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis

1996 • 313 citations

Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

1993 • 313 citations

Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia: Comparative Appearances at and Diagnostic Accuracy of Thin-Section CT

2001 • 309 citations

Syndromes of Telomere Shortening

2009 • 308 citations

Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

1995 • 306 citations

Cryptogenic Organizing Pneumonia

2000 • 306 citations

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

2000 • 303 citations

Chronic diffuse interstitial lung disease: diagnostic value of chest radiography and high-resolution CT.

1991 • 302 citations

Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

2003 • 301 citations

Connective Tissue Growth Factor Gene Regulation

2003 • 301 citations

Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?

1999 • 300 citations

Serum surfactant proteins‐A and ‐D as biomarkers in idiopathic pulmonary fibrosis

2002 • 299 citations

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma.

1999 • 297 citations

Stem Cells and Cell Therapies in Lung Biology and Lung Diseases

2008 • 297 citations

CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis.

1997 • 297 citations

Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic fibrosing alveolitis.

1989 • 296 citations

The Relationship between Individual Histologic Features and Disease Progression in Idiopathic Pulmonary Fibrosis

2002 • 295 citations

Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth Official Adult Lung and Heart/Lung Transplantation Report—2008

2008 • 294 citations

Renal Fibrosis

2001 • 292 citations

Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung

1998 • 291 citations

Physiology Is a Stronger Predictor of Survival than Pathology in Fibrotic Interstitial Pneumonia

2005 • 289 citations

Induction of Apoptosis and Pulmonary Fibrosis in Mice in Response to Ligation of Fas Antigen

1997 • 289 citations

Pulmonary Fibrosis

2005 • 288 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease

2009 • 287 citations

Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis.

1988 • 287 citations

Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis

1993 • 284 citations

Prognostic value of circulating KL‐6 in idiopathic pulmonary fibrosis

2006 • 283 citations

Prostaglandin E₂Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation

2003 • 282 citations

Antioxidative and Clinical Effects of High-doseN-Acetylcysteine in Fibrosing Alveolitis

1997 • 280 citations

The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UK

2007 • 279 citations

Mycophenolate mofetil

1996 • 273 citations

Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection

2007 • 272 citations

Failure of Bone Marrow to Reconstitute Lung Epithelium

2005 • 271 citations

Accelerated Variant of Idiopathic Pulmonary Fibrosis: Clinical Behavior and Gene Expression Pattern

2007 • 270 citations

A Clinical, Radiographic, and Physiologic Scoring System for the Longitudinal Assessment of Patients with Idiopathic Pulmonary Fibrosis^1–3

1986 • 269 citations

Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF

2004 • 267 citations

Recombinant Human Relaxin in the Treatment of Scleroderma

2000 • 267 citations

Mechanisms of Gas-exchange Impairment in Idiopathic Pulmonary Fibrosis

1991 • 267 citations

Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure.

1994 • 266 citations

Idiopathic Pulmonary Fibrosis

2000 • 265 citations

Six-Minute Walk, Maximal Exercise Tests

2005 • 263 citations

Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts

1998 • 263 citations

Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.

1998 • 259 citations

High short-term mortality following lung biopsy for usual interstitial pneumonia

2001 • 259 citations

The role of CXC chemokines in pulmonary fibrosis

2007 • 258 citations

Delayed Access and Survival in Idiopathic Pulmonary Fibrosis

2011 • 258 citations

Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice

2000 • 257 citations

Acetaminophen overdose: A 48-hour intravenous N-acetylcysteine treatment protocol

1991 • 255 citations

Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts

2005 • 255 citations

Cryptogenic fibrosing alveolitis. Relationships of pulmonary physiology and bronchoalveolar lavage to response to treatment and prognosis.

1981 • 253 citations

The prognosis of cryptogenic fibrosing alveolitis

1972 • 253 citations

Cryptogenic fibrosing alveolitis: response to corticosteroid treatment and its effect on survival

1980 • 253 citations

Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy.

1987 • 253 citations

Viral Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

2011 • 252 citations

Pulmonary Hypertension and Pulmonary Function Testing in Idiopathic Pulmonary Fibrosis

2007 • 251 citations

Histopathologic Features and Outcome of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis Undergoing Surgical Lung Biopsy

2005 • 250 citations

Sildenafil Improves Walk Distance in Idiopathic Pulmonary Fibrosis

2007 • 249 citations

Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor

2000 • 248 citations

Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

2001 • 248 citations

Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells

1989 • 247 citations

Fibroblastic Foci in Usual Interstitial Pneumonia

2003 • 246 citations

Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor

2004 • 246 citations

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis

1998 • 242 citations

Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases.

1998 • 242 citations

Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis?

1995 • 242 citations

Increased Endothelin-1 in Bleomycin-induced Pulmonary Fibrosis and the Effect of an Endothelin Receptor Antagonist

1997 • 241 citations

Idiopathic Pulmonary Fibrosis

2004 • 241 citations

Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

1988 • 241 citations

Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1

2001 • 241 citations

Extracellular BMP-antagonist regulation in development and disease: tied up in knots

2010 • 239 citations

Inter-observer variation between pathologists in diffuse parenchymal lung disease

2004 • 237 citations

Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators.

1986 • 235 citations

Pathologic and Radiologic Differences Between Idiopathic and Collagen Vascular Disease-Related Usual Interstitial Pneumonia

2009 • 235 citations

Pulmonary Function in Idiopathic Pulmonary Fibrosis and Referral for Lung Transplantation

2001 • 235 citations

Pigment Epithelium–derived Factor in Idiopathic Pulmonary Fibrosis

2004 • 234 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

1996 • 234 citations

Precapillary Systemic-pulmonary Anastomoses

1963 • 232 citations

IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis.

1999 • 232 citations

Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease

1999 • 231 citations

Correlation of lung surface area to apoptosis and proliferation in human emphysema

2005 • 229 citations

Adult familial cryptogenic fibrosing alveolitis in the United Kingdom

2000 • 229 citations

What causes cryptogenic fibrosing alveolitis? A case-control study of environmental exposure to dust.

1990 • 228 citations

Heterogeneous Proliferative Characteristics of Human Adult Lung Fibroblast Lines and Clonally Derived Fibroblasts from Control and Fibrotic Tissue

1988 • 228 citations

Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor

2004 • 228 citations

Prognostic Implications of Histologic Patterns in Multiple Surgical Lung Biopsies From Patients With Idiopathic Interstitial Pneumonias

2004 • 225 citations

Expression of Apoptotic and Antiapoptotic Markers in Epithelial Cells in Idiopathic Pulmonary Fibrosis

2005 • 222 citations

Targeting TGF-β overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade

1998 • 222 citations

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

2000 • 222 citations

Imatinib as a Novel Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice

2005 • 222 citations

Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)

2001 • 219 citations

Acute exacerbation of idiopathic pulmonary fibrosis: report of a series

2003 • 218 citations

Analyses of Efficacy End Points in a Controlled Trial of Interferon-γ1b for Idiopathic Pulmonary Fibrosis

2005 • 217 citations

Acute Exacerbation (Acute Lung Injury of Unknown Cause) in UIP and Other Forms of Fibrotic Interstitial Pneumonias

2007 • 216 citations

The Association between Idiopathic Pulmonary Fibrosis and Vascular Disease

2008 • 215 citations

Desquamative Interstitial Pneumonia and Respiratory Bronchiolitis-Associated Interstitial Lung Disease

2005 • 215 citations

British Thoracic Society study of cryptogenic fibrosing alveolitis: current presentation and initial management. Fibrosing Alveolitis Subcommittee of the Research Committee of the British Thoracic Society

1997 • 214 citations

Significance of Bronchoalveolar Lavage for the Diagnosis of Idiopathic Pulmonary Fibrosis

2009 • 214 citations

Disorders of lung matrix remodeling

2004 • 214 citations

Acute interstitial pneumonia

2000 • 213 citations

Abnormal Re-epithelialization and Lung Remodeling in Idiopathic Pulmonary Fibrosis: The Role of ΔN-p63

2002 • 212 citations

Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension

2007 • 209 citations

Angiotensin II blockade decreases TGF-β1 and matrix proteins in cyclosporine nephropathy

1997 • 207 citations

Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality.

1996 • 206 citations

Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor

2000 • 206 citations

Sole Treatment of Acid Gastroesophageal Reflux in Idiopathic Pulmonary Fibrosis

2006 • 204 citations

Simultaneous or Delayed Administration of Hepatocyte Growth Factor Equally Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin

1997 • 204 citations

Usual Interstitial Pneumonia

2002 • 203 citations

3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation

2002 • 203 citations

Chronic Lung Allograft Rejection: Mechanisms and Therapy

2009 • 202 citations

Effect of pirfenidone on the pulmonary fibrosis of Hermansky–Pudlak syndrome

2002 • 201 citations

Serial Development of Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis

2008 • 200 citations

Structure of alveolar epithelial cells in patients with fibrotic lung disorders.

1982 • 199 citations

The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis

1994 • 197 citations

High-Resolution Chest CT Findings Do Not Predict the Presence of Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis

2007 • 197 citations

The Detection of Epstein-Barr Virus DNA in Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis

1999 • 195 citations

Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice

2002 • 193 citations

Thrombin Differentiates Normal Lung Fibroblasts to a Myofibroblast Phenotype via the Proteolytically Activated Receptor-1 and a Protein Kinase C-dependent Pathway

2001 • 192 citations

Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis

1991 • 192 citations

Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF

2001 • 192 citations

Pulmonary fibrosis and lung cancer: risk and benefit analysis of pulmonary resection

2003 • 191 citations

Interstitial Vascularity in Fibrosing Alveolitis

2003 • 191 citations

Prevalence of Gastroesophageal Reflux in End-Stage Lung Disease Candidates for Lung Transplant

2005 • 191 citations

Inhibition of Pulmonary Fibrosis by the Chemokine IP-10/CXCL10

2004 • 189 citations

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

1993 • 188 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lung.

1997 • 187 citations

Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo

2001 • 187 citations

Increased Risk of Fibrosing Alveolitis Associated with Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor- α Gene Polymorphisms

2000 • 186 citations

Quality of life of idiopathic pulmonary fibrosis patients

2001 • 185 citations

Colchicine versus Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis

1998 • 185 citations

Outcome of Patients with Idiopathic Pulmonary Fibrosis Admitted to the Intensive Care Unit

2002 • 184 citations

Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin

2001 • 184 citations

Expression of TNF and the Necessity of TNF Receptors in Bleomycin-Induced Lung Injury in Mice

1998 • 184 citations

Future Research Directions in Idiopathic Pulmonary Fibrosis

2002 • 183 citations

Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis

1995 • 183 citations

Association of Malignancy With Diseases Causing Interstitial Pulmonary Changes

2002 • 182 citations

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

1996 • 182 citations

The timed walk test as a measure of severity and survival in idiopathic pulmonary fibrosis

2005 • 180 citations

Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival∗∗Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/

2001 • 180 citations

Lung Morphology in the Elderly: Comparative CT Study of Subjects over 75 Years Old versus Those under 55 Years Old

2009 • 180 citations

Survival in Patients With Cryptogenic Fibrosing Alveolitis

1998 • 179 citations

Idiopathic Pulmonary Fibrosis

2007 • 179 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Diminished Prostaglandin E₂Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

2010 • 178 citations

The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: Demonstration of a ceiling effect

2005 • 178 citations

Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury

1997 • 178 citations

Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis

1997 • 178 citations

Keratinocyte growth factor reduces lung damage due to acid instillation in rats.

1996 • 178 citations

Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

1999 • 177 citations

Pathophysiology of Activity Limitation in Patients With Interstitial Lung Disease

1996 • 177 citations

Quadriceps Weakness Is Related to Exercise Capacity in Idiopathic Pulmonary Fibrosis

2005 • 176 citations

Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis.

1996 • 175 citations

Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century

2014 • 175 citations

Potential Contribution of a Novel Antifibrotic Factor, Hepatocyte Growth Factor, to Prevention of Myocardial Fibrosis by Angiotensin II Blockade in Cardiomyopathic Hamsters

2000 • 175 citations

Use of the General Practice Research Database (GPRD) for respiratory epidemiology: a comparison with the 4th Morbidity Survey in General Practice (MSGP4)

1999 • 174 citations

Diffuse interstitial pneumonitis

1978 • 174 citations

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

2008 • 174 citations

Proliferation of Pulmonary Interstitial Fibroblasts Is Mediated by Transforming Growth Factor-β1-induced Release of Extracellular Fibroblast Growth Factor-2 and Phosphorylation of p38 MAPK and JNK

2005 • 173 citations

Current Perspectives on the Treatment of Idiopathic Pulmonary Fibrosis

2006 • 173 citations

Asbestos Fibers and Silica Particles Stimulate Rat Alveolar Macrophages To Release Tumor Necrosis Factor: Autoregulatory Role of Leukotriene B₄

1989 • 173 citations

Pathogenesis of “fibrosis” in interstitial pneumonia: An electron microscopic study

1985 • 172 citations

Differences in the Fibrogenic Response after Transfer of Active Transforming Growth Factor-β1 Gene to Lungs of “Fibrosis-prone” and “Fibrosis-resistant” Mouse Strains

2002 • 171 citations

Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor

2001 • 171 citations

Transforming Growth Factor-β₁ Gene Polymorphisms Are Associated with Disease Progression in Idiopathic Pulmonary Fibrosis

2003 • 171 citations

Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines.

1997 • 171 citations

Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases

2008 • 170 citations

Factor Xa: at the crossroads between coagulation and signaling in physiology and disease

2008 • 170 citations

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

2002 • 169 citations

Pulmonary Function and High-Resolution CT Findings in Patients With an Inherited Form of Pulmonary Fibrosis, Hermansky-Pudlak Syndrome, Due to Mutations in HPS-1

2000 • 169 citations

Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

1999 • 169 citations

Proteoglycan deposition in pulmonary fibrosis.

1996 • 169 citations

Prevalence and impact of coronary artery disease in idiopathic pulmonary fibrosis

2010 • 169 citations

Fibroblasts as Sentinel Cells

2001 • 168 citations

Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK

2004 • 167 citations

HGF reduces advancing lung fibrosis in mice: a potential role for MMP‐dependent myofibroblast apoptosis

2005 • 167 citations

Release of biologically active TGF-β1 by alveolar epithelial cells results in pulmonary fibrosis

2003 • 167 citations

The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogenic fibrosing alveolitis.

1987 • 167 citations

Prostaglandin E₂inhibits fibroblast chemotaxis

2001 • 164 citations

Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis.

1995 • 164 citations

Copper Control as an Antiangiogenic Anticancer Therapy: Lessons from Treating Wilson's Disease

2001 • 164 citations

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: Implications for antifibrotic therapy

2002 • 163 citations

CXCL11 Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling

2004 • 163 citations

Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins

2000 • 163 citations

Re-evaluation of Fibrogenic Cytokines in Lung Fibrosis

2003 • 162 citations

Bronchoalveolar lavage in interstitial lung disease

2001 • 160 citations

Pirfenidone effectively reverses experimental liver fibrosis

2002 • 160 citations

Transforming growth factor-β1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction

2000 • 160 citations

Triggering the Induction of Myofibroblast and Fibrogenesis by Airway Epithelial Shedding

2001 • 159 citations

Outcome of Patients Admitted to Intensive Care Unit for Acute Exacerbation of Idiopathic Pulmonary Fibrosis

2004 • 159 citations

TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract

2002 • 158 citations

Transforming Growth Factor-β- and Tumor Necrosis Factor-α-mediated Induction and Proteolytic Activation of MMP-9 in Human Skin

2001 • 158 citations

Prognosis of cryptogenic fibrosing alveolitis.

1983 • 158 citations

Early Interstitial Lung Disease in Familial Pulmonary Fibrosis

2007 • 157 citations

Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis

2004 • 156 citations

Reactive pulmonary lymphoid disorders

1995 • 155 citations

Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells

2003 • 155 citations

Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders.

1997 • 154 citations

Outcomes and Safety of Surgical Lung Biopsy for Interstitial Lung Disease

2005 • 154 citations

Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation

2007 • 154 citations

Transforming Growth Factor-β and Angiotensin II: The Missing Link from Glomerular Hyperfiltration to Glomerulosclerosis?

1995 • 154 citations

Pulmonary Fibroblast Expression of Interleukin-8: A Model for Alveolar Macrophage-derived Cytokine Networking

1991 • 153 citations

Pulmonary Function Testing in Idiopathic Interstitial Pneumonias

2006 • 153 citations

NF-kappaB Inhibits Expression of the alpha1(I) Collagen Gene

1999 • 152 citations

Losartan decreases plasma levels of TGF-β1 in transplant patients with chronic allograft nephropathy

1999 • 152 citations

Determinants of progression in idiopathic pulmonary fibrosis.

1994 • 152 citations

Tissue Factor Expression and Fibrin Deposition in the Lungs of Patients with Idiopathic Pulmonary Fibrosis and Systemic Sclerosis

1997 • 151 citations

Disease Progression in Usual Interstitial Pneumonia Compared With Desquamative Interstitial Pneumonia

1996 • 151 citations

Combined Corticosteroid and Cyclophosphamide Therapy Does Not Alter Survival in Idiopathic Pulmonary Fibrosis

2004 • 151 citations

Lone cryptogenic fibrosing alveolitis: a functional-morphologic correlation based on extent of disease on thin-section computed tomography.

1997 • 150 citations

Differential Proliferation of Fibroblasts Cultured from Normal and Fibrotic Human Lungs

1988 • 149 citations

Prostaglandin E₂Synthesis and Suppression of Fibroblast Proliferation by Alveolar Epithelial Cells Is Cyclooxygenase-2–Dependent

2002 • 149 citations

The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts.

1982 • 147 citations

Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.

1998 • 147 citations

GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism

2000 • 147 citations

Marrow-Derived Cells as Vehicles for Delivery of Gene Therapy to Pulmonary Epithelium

2002 • 146 citations

Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.

1995 • 146 citations

Corticosteroids and the Treatment of Idiopathic Pulmonary Fibrosis

1996 • 146 citations

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema

2005 • 145 citations

Interferon-γ inhibits experimental renal fibrosis

1999 • 144 citations

Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis

2000 • 144 citations

Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro

1995 • 143 citations

Role of matrix metalloproteinases in epithelial migration

2009 • 141 citations

Analysis of Tumor Necrosis Factor- α , Lymphotoxin- α , Tumor Necrosis Factor Receptor II, and Interleukin-6 Polymorphisms in Patients with Idiopathic Pulmonary Fibrosis

2001 • 141 citations

Wwp2, an E3 Ubiquitin Ligase That Targets Transcription Factor Oct-4 for Ubiquitination

2004 • 141 citations

Factors Influencing Survival in Children with Chronic Interstitial Lung Disease

1997 • 140 citations

A step test to assess exercise-related oxygen desaturation in interstitial lung disease

2006 • 140 citations

Histologic Spectrum of Idiopathic Interstitial Pneumonias

2006 • 139 citations

Changes in Pulmonary Function Test Results After 1 Year of Therapy as Predictors of Survival in Patients With Idiopathic Pulmonary Fibrosis

1995 • 139 citations

High-Resolution Computed Tomography Features of Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia

2005 • 139 citations

Cryptogenic fibrosing alveolitis with preserved lung volumes

1997 • 137 citations

Pulmonary fibrosis deaths in the United States, 1979-1991. An analysis of multiple-cause mortality data.

1996 • 136 citations

IL-12 attenuates bleomycin-induced pulmonary fibrosis

2001 • 135 citations

Outcome of patients with idiopathic pulmonary fibrosis (IPF) ventilated in intensive care unit

2008 • 135 citations

Chemokines and CD40 expression in human fibroblasts

2000 • 134 citations

Acute Interstitial Pneumonitis: Case Series and Review of the Literature

2000 • 134 citations

Colchicine, D-Penicillamine, and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis

1998 • 133 citations

Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro.

1994 • 133 citations

Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction

1999 • 133 citations

Transplantation of Human Embryonic Stem Cell–Derived Alveolar Epithelial Type II Cells Abrogates Acute Lung Injury in Mice

2010 • 133 citations

ENA-78 Is an Important Angiogenic Factor in Idiopathic Pulmonary Fibrosis

2001 • 132 citations

Adenoviral Gene Transfer of Connective Tissue Growth Factor in the Lung Induces Transient Fibrosis

2003 • 131 citations

Pathogenesis and Natural History of Usual Interstitial Pneumonia

2005 • 130 citations

BIOSYNTHESIS AND MATURATION OF SKIN COLLAGEN IN SCLERODERMA, AND EFFECT OF D-PENICILLAMINE

1974 • 130 citations

Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts

2001 • 130 citations

A Rearranged Form of Epstein–Barr Virus DNA Is Associated with Idiopathic Pulmonary Fibrosis

2002 • 130 citations

Augmentation of Functional Prostaglandin E Levels on the Respiratory Epithelial Surface by Aerosol Administration of Prostaglandin E

1991 • 129 citations

Open-label Compassionate Use One Year-treatment with Pirfenidone to Patients with Chronic Pulmonary Fibrosis.

2002 • 129 citations

Hepatocyte growth factor counteracts transforming growth factor‐β₁, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice

2002 • 129 citations

Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides

1999 • 128 citations

Treatment of chronic myelogenous leukemia with the tyrosine kinase inhibitor STI571 results in marked regression of bone marrow fibrosis

2002 • 128 citations

Pharmacological Therapy for Idiopathic Pulmonary Fibrosis

1999 • 127 citations

Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals.

2000 • 126 citations

Rho‐dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)

2001 • 126 citations

Prostaglandin E₂ Inhibits Fibroblast Migration by E-Prostanoid 2 Receptor–Mediated Increase in PTEN Activity

2004 • 126 citations

Overexpression of Tumor Necrosis Factor-α Diminishes Pulmonary Fibrosis Induced by Bleomycin or Transforming Growth Factor-β

2003 • 125 citations

CA repeat allele polymorphism in the first intron of the human interferon-γ gene is associated with lung allograft fibrosis

1999 • 124 citations

Attenuation of Lung Inflammation and Fibrosis in Interferon- γ –Deficient Mice after Intratracheal Bleomycin

2001 • 124 citations

The Diagnostic and Therapeutic Utility of Thoracoscopy

1995 • 124 citations

Angiogenic cytokines in patients with idiopathic interstitial pneumonia

2004 • 124 citations

Interstitial lung diseases in collagen vascular diseases

2001 • 124 citations

Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1

2002 • 123 citations

Modulation of Prosurvival Signaling in Fibroblasts by a Protein Kinase Inhibitor Protects against Fibrotic Tissue Injury

2005 • 123 citations

Role of diabetes mellitus and gastro-oesophageal reflux in the aetiology of idiopathic pulmonary fibrosis

2008 • 122 citations

Human Relaxin Decreases Collagen Accumulation In Vivo in Two Rodent Models of Fibrosis

1993 • 122 citations

Rising mortality from cryptogenic fibrosing alveolitis.

1990 • 121 citations

The Role of Hepatic Stellate Cells and Transforming Growth Factor-β1 in Cystic Fibrosis Liver Disease

2002 • 121 citations

Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis.

1995 • 120 citations

Usual Interstitial Pneumonia and Chronic Idiopathic Interstitial Pneumonia: Analysis of CT Appearance in 92 Patients

2006 • 120 citations

Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia

2005 • 118 citations

Radiologic–pathologic discordance in biopsy-proven usual interstitial pneumonia

2016 • 117 citations

Pirfenidone Treatment Decreases Transforming Growth Factor-β1 and Matrix Proteins and Ameliorates Fibrosis in Chronic Cyclosporine Nephrotoxicity

2002 • 117 citations

Essential Roles for Angiotensin Receptor AT1a in Bleomycin-Induced Apoptosis and Lung Fibrosis in Mice

2003 • 117 citations

Accelerated Skin Wound Healing in Plasminogen Activator Inhibitor-1-Deficient Mice

2001 • 117 citations

Peribiliary myofibroblasts in biliary type liver fibrosis

2002 • 116 citations

Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist

2003 • 116 citations

Terminal Diffuse Alveolar Damage in Relation to Interstitial Pneumonias: An Autopsy Study

2003 • 115 citations

Angiotensin receptor subtype AT₁ mediates alveolar epithelial cell apoptosis in response to ANG II

2002 • 115 citations

T cell independence of bleomycin-induced pulmonary fibrosis

1999 • 114 citations

Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism

1998 • 114 citations

Occupational and Environmental Factors and Idiopathic Pulmonary Fibrosis in Japan

2005 • 113 citations

Focal Segmental Glomerulosclerosis

1999 • 113 citations

Idiopathic Interstitial Pneumonias: Prevalence of Mediastinal Lymph Node Enlargement in 206 Patients

2006 • 113 citations

A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis

2002 • 113 citations

Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE₂

2003 • 112 citations

Pulmonary Function Tests and CT Scan in the Management of Idiopathic Pulmonary Fibrosis

1998 • 112 citations

CONTRACTION OF FIBROBLAST-CONTAINING COLLAGEN GELS: INITIAL COLLAGEN CONCENTRATION REGULATES THE DEGREE OF CONTRACTION AND CELL SURVIVAL

2001 • 112 citations

Preventive effect of pirfenidone against experimental sclerosing peritonitis in rats

1995 • 111 citations

RETRACTED: TGF-β1 induces alveolar epithelial to mesenchymal transition in vitro

2004 • 111 citations

Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema

2005 • 110 citations

Mortality rates from cryptogenic fibrosing alveolitis in seven countries.

1996 • 110 citations

The Prevalence of Distal and Proximal Gastroesophageal Reflux in Patients Awaiting Lung Transplantation

2006 • 110 citations

The Differential Effect of Prostaglandin E2 on Transforming Growth Factor-β and Insulin-induced Collagen Formation in Lung Fibroblasts

1989 • 110 citations

Experience with azathioprine in systemic sclerosis associated with interstitial lung disease

2004 • 109 citations

British Thoracic Society Study on cryptogenic fibrosing alveolitis: response to treatment and survival

2006 • 108 citations

Deactivation of cultured human liver myofibroblasts by Trans -resveratrol, a grapevine-derived polyphenol

2000 • 108 citations

Bile-duct destruction and collagen deposition: A prominent ultrastructural feature of the liver in cystic fibrosis

1992 • 108 citations

Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor.

1997 • 107 citations

Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals.

1995 • 107 citations

uPA/Plasmin System-Mediated MMP-9 Activation Is Implicated in Bronchial Epithelial Cell Migration

2001 • 107 citations

Pulmonary rehabilitation in idiopathic pulmonary fibrosis: A call for continued investigation

2008 • 106 citations

The Prognostic Value of Cardiopulmonary Exercise Testing in Idiopathic Pulmonary Fibrosis

2008 • 106 citations

Prediction of pulmonary hypertension in idiopathic pulmonary fibrosis

2007 • 106 citations

Idiopathic diffuse interstitial pulmonary fibrosis (fibrosing alveolitis), atypical epithelial proliferation and lung cancer

1968 • 106 citations

Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney

2002 • 105 citations

Type 1/Type 2 Cytokine Paradigm and the Progression of Pulmonary Fibrosis

2001 • 105 citations

Terminal Diffuse Alveolar Damage in Relation to Interstitial Pneumonias

2003 • 104 citations

Pulmonary fibrosis associated with ANCA-positive vasculitides. Retrospective study of 12 cases and review of the literature

2008 • 104 citations

Autopsy findings in 42 consecutive patients with idiopathic pulmonary fibrosis

2008 • 104 citations

Lung Fibrosis is Ameliorated by Pirfenidone Fed in Diet After the Second Dose In A Three-Dose Bleomycin-Hamster Model

1998 • 104 citations

Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin

1994 • 103 citations

Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis

2004 • 103 citations

Treatment of Bleomycin-Induced Pulmonary Fibrosis by Transfer of Urokinase-Type Plasminogen Activator Genes

1999 • 102 citations

Effect of γ-Interferon on Collagen Synthesis by Normal and Fibrotic Human Lung Fibroblasts

1992 • 102 citations

Correlation of structure and function in idiopathic pulmonary fibrosis.

1995 • 101 citations

Transforming Growth Factor-β1-induced Activation of the ERK Pathway/Activator Protein-1 in Human Lung Fibroblasts Requires the Autocrine Induction of Basic Fibroblast Growth Factor

2000 • 101 citations

Lovastatin Induces Fibroblast ApoptosisIn Vitro and In Vivo

1999 • 101 citations

Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms

2002 • 101 citations

Genetics of fibrosing lung diseases

2005 • 100 citations

Does Idiopathic Pulmonary Fibrosis Increase Lung Cancer Risk?

2000 • 100 citations

Impact of Recipient Age and Procedure Type on Survival After Lung Transplantation for Pulmonary Fibrosis

2005 • 100 citations

Use of Intermittent, Intravenous Cyclophosphamide for Idiopathic Pulmonary Fibrosis

1992 • 98 citations

Pulmonary Hemodynamics in Idiopathic Pulmonary Fibrosis and Other Interstitial Pulmonary Diseases

1983 • 98 citations

Organ Allocation in Lung Transplant

2007 • 97 citations

The effect of D‐penicillamine on pulmonary findings in systemic sclerosis

1985 • 97 citations

Exercise testing determines survival in patients with diffuse parenchymal lung disease evaluated for lung transplantation

2005 • 96 citations

Infliximab

2002 • 96 citations

Cyclophosphamide in the Treatment of Idiopathic Pulmonary Fibrosis

2000 • 95 citations

Enhanced migration of fibroblasts derived from lungs with fibrotic lesions.

1995 • 95 citations

Molecular mechanisms of pulmonary fibrosis

2002 • 94 citations

A computer program using BALF-analysis results as a diagnostic tool in interstitial lung diseases.

1996 • 93 citations

Repression of Bleomycin-Induced Pneumopathy by TNF

2003 • 92 citations

Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice

2001 • 92 citations

Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy.

1997 • 91 citations

Infliximab therapy in pulmonary fibrosis associated with collagen vascular disease.

2007 • 91 citations

Oxidants/antioxidants in idiopathic pulmonary fibrosis.

1995 • 90 citations

Recombinant gamma, alpha, and beta interferon regulation of human lung fibroblast proliferation.

1987 • 90 citations

Radiation pneumotoxicity in rats: Modification by inhibitors of angiotensin converting enzyme

1992 • 89 citations

PDE4 Inhibitors Attenuate Fibroblast Chemotaxis and Contraction of Native Collagen Gels

2002 • 89 citations

Pulmonary fibrosis in families.

2003 • 87 citations

Computed Tomographic Features of Idiopathic Fibrosing Interstitial Pneumonia

2009 • 87 citations

Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis A quantitative study of open lung biopsies

1999 • 87 citations

Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation

2003 • 87 citations

Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis.

1998 • 87 citations

Effect of endothelin-1 on α-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases

1999 • 87 citations

D‐penicillamine therapy and interstitial lung disease in scleroderma. a long‐term followup study

1987 • 85 citations

Idiopathic Pulmonary Fibrosis: How Often Is It Really Idiopathic?

2005 • 85 citations

Pulmonary fibrosis and lung carcinoma: A comparative study of metaplastic epithelia in honeycombed areas of usual interstitial pneumonia with or without lung carcinoma

1999 • 85 citations

Functional impairment in lone cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a comparison.

1997 • 84 citations

Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice

2002 • 84 citations

Colchicine Suppresses the Release of Fibroblast Growth Factors from Alveolar MacrophagesIn Vitro: The Basis of a Possible Therapeutic Approach to the Fibrotic Disorders

1988 • 84 citations

The ultrastructure of human fibrosing alveolitis

1982 • 83 citations

Postoperative morbidity, mortality, and survival in lung cancer associated with idiopathic pulmonary fibrosis

2002 • 83 citations

Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction

1997 • 82 citations

Colchicine in the Treatment of Pulmonary Fibrosis

1993 • 82 citations

Role of thrombin and its major cellular receptor, protease-activated receptor-I, in pulmonary fibrosis

2002 • 82 citations

Extracellular Glutathione Suppresses Human Lung Fibroblast Proliferation

1990 • 81 citations

Effects of interferon-gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts.

1989 • 81 citations

Tyrosine Phosphorylation Regulates H2O2Production in Lung Fibroblasts Stimulated by Transforming Growth Factor β1

1998 • 81 citations

Inhibition of tumor necrosis factor and subsequent endotoxin shock by pirfenidone

1998 • 80 citations

Targeting Genes for Treatment in Idiopathic Pulmonary Fibrosis: Challenges and Opportunities, Promises and Pitfalls

2006 • 80 citations

Antiinflammatory and Antifibrotic Properties of Colchicine: Implications for Idiopathic Pulmonary Fibrosis

1997 • 79 citations

3-T MRI for Differentiating Inflammation- and Fibrosis-Predominant Lesions of Usual and Nonspecific Interstitial Pneumonia: Comparison Study with Pathologic Correlation

2008 • 77 citations

Effects of pirfenidone on the generation of reactive oxygen species in vitro.

1999 • 77 citations

Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice

2008 • 77 citations

Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury

2004 • 77 citations

Occupational exposure and severe pulmonary fibrosis

2007 • 76 citations

A Comparison of the Clinical Features of ANCA-Positive and ANCA-Negative Idiopathic Pulmonary Fibrosis Patients

2008 • 76 citations

Expression of tumour necrosis factor‐α in cryptogenic fibrosing alveolitis

1993 • 76 citations

Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosis

2000 • 76 citations

Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice

1997 • 75 citations

Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis

1995 • 75 citations

The management of cryptogenic fibrosing alveolitis in three regions of the United Kingdom

1993 • 75 citations

Myofibroblasts: Molecular crossdressers

2001 • 74 citations

Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice

2003 • 74 citations

Bronchoalveolar lavage in fibrotic idiopathic interstitial pneumonias

2006 • 74 citations

Ventilation-Perfusion Matching during Exercise

1992 • 74 citations

A 15-year prospective study of treatment of rapidly progressive systemic sclerosis with D-penicillamine [see comment].

1991 • 73 citations

Pharmacologic Suppression of the Neutrophil Component of the Alveolitis in Idiopathic Pulmonary Fibrosis

1987 • 73 citations

Fine structural changes in cryptogenic fibrosing alveolitis and asbestosis

1985 • 73 citations

Interferon-γ Coordinately Upregulates Matrix Metalloprotease (MMP)-1 and MMP-3, But Not Tissue Inhibitor of Metalloproteases (TIMP), Expression in Cultured Keratinocytes

1995 • 73 citations

Induction of Telomerase Activity in Fibroblasts from Bleomycin-Injured Lungs

2000 • 73 citations

Eicosanoids: mediators and therapeutic targets in fibrotic lung disease

2005 • 73 citations

Cyclosporin as a treatment for interstitial lung disease of unknown aetiology.

1991 • 73 citations

Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeleton

2001 • 72 citations

Lung Transplantation

2005 • 72 citations

Fibre differentiation and polarity in the mammalian lens: a key role for FGF

1997 • 72 citations

Pirfenidone induces intercellular adhesion molecule-1 (ICAM-1) down-regulation on cultured human synovial fibroblasts

1998 • 72 citations

Apoptotic Activity is Increased in the Newly Formed Fibromyxoid Connective Tissue in Bronchiolitis Obliterans Organizing Pneumonia

1999 • 72 citations

Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro.

1995 • 72 citations

Human Pulmonary Fibroblasts Exhibit Altered Interleukin-4 and Interleukin-13 Receptor Subunit Expression in Idiopathic Interstitial Pneumonia

2004 • 71 citations

A pilot study of aerosolized N‐acetylcysteine for idiopathic pulmonary fibrosis

2005 • 71 citations

Defect of Hepatocyte Growth Factor Secretion by Fibroblasts in Idiopathic Pulmonary Fibrosis

2003 • 70 citations

Induction of Lung Fibroblast Apoptosis by Soluble Fibronectin Peptides

2000 • 70 citations

Different patterns of gas exchange response to exercise in asbestosis and idiopathic pulmonary fibrosis

1988 • 69 citations

Epidemiology of Acute Lung Injury and Acute Respiratory Distress Syndrome

2006 • 69 citations

The enigma of focal segmental glomerulosclerosis.

1996 • 69 citations

Pulmonary Fibrosis and Lung Cancer in the United States: Analysis of the Multiple Cause of Death Mortality Data, 1979 Through 1991

1996 • 69 citations

Mineral Dusts Directly Induce Epithelial and Interstitial Fibrogenic Mediators and Matrix Components in the Airway Wall

1998 • 68 citations

Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue.

1994 • 68 citations

Pulmonary 99mTc-DTPA aerosol clearance and survival in usual interstitial pneumonia (UIP)

2001 • 68 citations

Relaxin Alone and in Conjunction with Interferon-γ Decreases Collagen Synthesis by Cultured Human Scleroderma Fibroblasts

1992 • 68 citations

Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis

2001 • 68 citations

Plasminogen Activator Inhibitor–1 Impairs Alveolar Epithelial Repair by Binding to Vitronectin

2004 • 67 citations

Early Intervention Can Improve Clinical Outcome of Acute Interstitial Pneumonia

2006 • 67 citations

Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia: Imaging Diagnosis, Spectrum of Abnormalities, and Temporal Progression

2006 • 67 citations

Phenotypic Characteristics and Cyclin-Dependent Kinase Inhibitors Repression in Hyperplastic Epithelial Pathology in Idiopathic Focal Segmental Glomerulosclerosis

2000 • 66 citations

Oxidative Protein Cross-linking Reactions Involvingl-Tyrosine in Transforming Growth Factor-β1-stimulated Fibroblasts

2001 • 66 citations

Resting and exercise physiology in interstitial lung diseases

2004 • 65 citations

Neutrophil Chemotactic Factors in the Respiratory Tract of Patients with Chronic Airway Diseases or Idiopathic Pulmonary Fibrosis

1992 • 65 citations

Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D

2006 • 65 citations

Opacification of the posterior capsule.

1985 • 64 citations

Colchicine Versus Prednisone as Treatment of Usual Interstitial Pneumonia

1997 • 64 citations

Alveolar Macrophages from Patients with Asbestos Exposure Release Increased Levels of Leukotriene B₄

1989 • 63 citations

Relevance of Tissue Factor and Tissue Factor Pathway Inhibitor for Hypercoagulable State in the Lungs of Patients with Idiopathic Pulmonary Fibrosis

2000 • 63 citations

Inhibition of fibroblast chemotaxis by recombinant human interferon γ and interferon α

1987 • 62 citations

Assessment of current practice in the diagnosis and therapy of idiopathic pulmonary fibrosis

2008 • 62 citations

Captopril Inhibits Proliferation of Human Lung Fibroblasts in Culture: A Potential Antifibrotic Mechanism

1994 • 62 citations

RETRACTED: Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy

1998 • 62 citations

Hospital-based historical cohort study of 234 histologically proven Japanese patients with IPF.

1999 • 62 citations

Accuracy of mortality data for interstitial lung diseases in New Mexico, USA.

1996 • 61 citations

Outcome of Subjects With Idiopathic Pulmonary Fibrosis Who Fail Corticosteroid Therapy

1993 • 61 citations

Overexpression of the transforming growth factor-beta-inducible gene betaig-h3 in anterior polar cataracts.

2000 • 60 citations

Upregulated Expression of Fibroblast Growth Factor (FGF) Receptors by Transforming Growth Factor-β1 (TGF-β1) Mediates Enhanced Mitogenic Responses to FGFs in Cultured Human Lung Fibroblasts

1998 • 60 citations

Cytokine gene polymorphisms in idiopathic pulmonary fibrosis

2004 • 60 citations

Idiopathic Pulmonary Fibrosis: Evaluation with Positron Emission Tomography

2005 • 60 citations

Immunocytochemistry of types I-IV collagen in human anterior subcapsular cataracts

1993 • 59 citations

The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced by thioacetamide

2000 • 58 citations

Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation

1997 • 58 citations

Viruses and idiopathic pulmonary fibrosis

1997 • 58 citations

Pirfenidone in the treatment of primary sclerosing cholangitis.

2002 • 58 citations

Effect of Endothelin Receptor Antagonists (BQ-485, Ro 47-0203) on Collagen Deposition During the Development of Bleomycin-Induced Pulmonary Fibrosis in Rats

1998 • 57 citations

Transforming Growth Factor–β Antagonizes Alveolar Type II Cell Proliferation Induced by Keratinocyte Growth Factor

2004 • 57 citations

Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor-beta1 inhibits fibrogenic activities of hepatic stellate cells.

2002 • 57 citations

The Myofibroblast as an Inflammatory Cell in Pulmonary Fibrosis

1999 • 57 citations

Occupational Risks for Idiopathic Pulmonary Fibrosis Mortality in the United States

2008 • 57 citations

Normal scarring: importance of myofibroblasts

2002 • 57 citations

Endothelin A Receptor Blockade Decreases Expression of Growth Factors and Collagen and Improves Matrix Metalloproteinase-2 Activity in Kidneys from Stroke-Prone Spontaneously Hypertensive Rats

2002 • 57 citations

Usual Interstitial Pneumonia

2001 • 56 citations

Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis

2001 • 56 citations

ALTERATIONS IN CYTOKERATIN EXPRESSION BY THE ALVEOLAR LINING EPITHELIAL CELLS IN LUNG TISSUES FROM PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS

1997 • 54 citations

Discordance between general and pulmonary pathologists in the diagnosis of interstitial lung disease

2005 • 53 citations

Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia

2004 • 53 citations

Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis

2000 • 52 citations

Interferon‐γ inhibits the myofibroblastic phenotype of rat palatal fibroblasts induced by transforming growth factor‐β1 in vitro

1999 • 52 citations

Soluble Transforming Growth Factor- β Type III Receptor Gene Transfection Inhibits Fibrous Airway Obliteration in a Rat Model of Bronchiolitis Obliterans

2002 • 52 citations

Acidic fibroblast growth factor and keratinocyte growth factor stimulate fetal rat pulmonary epithelial growth

1996 • 52 citations

Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis?

2002 • 52 citations

Interferon and Growth Factor Activity for Human Lung Fibroblasts

1986 • 51 citations

Coal Worker’s Pneumoconiosis

2010 • 51 citations

Functional impairment in fibrosing alveolitis: relationship to reversible disease on thin section computed tomography

1997 • 51 citations

Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis

2004 • 51 citations

Cyclophosphamide pulse therapy in idiopathic pulmonary fibrosis

1998 • 50 citations

Angiogenesis in pathological and surgical scars

1998 • 49 citations

Impairment of Bleomycin-Induced Lung Fibrosis in CD28-Deficient Mice

2001 • 49 citations

Inhalation of inorganic particles as a risk factor for idiopathic pulmonary fibrosis—Elemental microanalysis of pulmonary lymph nodes obtained at autopsy cases

2007 • 49 citations

Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs

2004 • 48 citations

Case-Control Study of Idiopathic Pulmonary Fibrosis and Environmental Exposures

1998 • 48 citations

Endothelin-1 Induces Bronchial Myofibroblast Differentiation

1997 • 48 citations

Clinical usefulness of high resolution computed tomography in cryptogenic fibrosing alveolitis

1998 • 48 citations

Neutralization of transforming growth factor-beta 1 in a mouse model of immune-induced lung fibrosis.

1994 • 47 citations

Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A

1989 • 47 citations

Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.

1993 • 46 citations

Skin collagen in patients with scleroderma: biosynthesis and maturation in vitro, and the effect of D-penicillamine.

1970 • 45 citations

The Fas/Fas-Ligand System Is Not Required for Bleomycin-induced Pulmonary Fibrosis in Mice

2000 • 45 citations

Determinants of response to immunosuppressive therapy in idiopathic pulmonary fibrosis

1994 • 45 citations

Hyperplastic epithelial foci in honeycomb lesions in idiopathic pulmonary fibrosis

2002 • 45 citations

The prognosis of idiopathic pulmonary fibrosis.

2003 • 44 citations

Clinical Evaluation of the Management of Community-Acquired Pneumonia by General Practitioners in France

2001 • 44 citations

Corticosteroids in idiopathic pulmonary fibrosis

2001 • 44 citations

Recurrent Nephrotic Syndrome in Renal Allografts

1988 • 44 citations

Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy

2004 • 44 citations

Proliferative Characteristics of Fibroblast Lines Derived from Open Lung Biopsy Specimens of Patients with IPF (UIP)

1992 • 43 citations

IFN-γ fails to antagonize fibrotic effect of TGF-β on keloid-derived dermal fibroblasts

2003 • 42 citations

SELECTIVE INHIBITION OF COLLAGEN GENE EXPRESSION IN FIBROBLASTS BY AN INTERFERON-gamma TRANSGENE

1999 • 41 citations

Keratinocyte Growth Factor Expression by Fibroblasts in Pulmonary Fibrosis

2005 • 41 citations

MicroRNA group disorganization in aging

2009 • 41 citations

Immune Interferon Is a Growth Factor for Human Lung Fibroblasts^1–4

1986 • 41 citations

Prominin-1/CD133⁺ Lung Epithelial Progenitors Protect from Bleomycin-induced Pulmonary Fibrosis

2009 • 39 citations

Seasonal Variation

2008 • 39 citations

Tenascin mRNA Expression at the Foci of Recent Injury in Usual Interstitial Pneumonia

2000 • 39 citations

Fibroblast Contractility

2000 • 38 citations

Idiopathic Pulmonary Fibrosis: Current Clinical Concepts and Challenges in Management

1994 • 38 citations

Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females.

1998 • 38 citations

Usual Interstitial Pneumonia

2006 • 38 citations

Endothelin-1 Secretion by Alveolar Macrophages in Systemic Sclerosis

1997 • 37 citations

Association between ischaemic heart disease and interstitial lung disease: A case–control study

2009 • 36 citations

Immune effector cells in idiopathic pulmonary fibrosis

1997 • 36 citations

Overview of Lung Transplantation and Criteria for Selection of Candidates

2006 • 36 citations

Bronchoalveolar Lavage in Idiopathic Interstitial Lung Diseases

2007 • 36 citations

Bone marrow stem cells do not repopulate the healthy upper respiratory tract

2002 • 35 citations

Nonspecific Interstitial Pneumonia (NSIP)

2001 • 35 citations

Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair.

1993 • 34 citations

The role of pulmonary function testing in pulmonary fibrosis

2000 • 34 citations

High prevalence of abnormal acid gastrooesophageal reflux in idiopathic pulmonary fibrosis

2007 • 31 citations

Epidemiology of Idiopathic Pulmonary Fibrosis

1993 • 30 citations

Increased serum levels of endostatin in patients with idiopathic pulmonary fibrosis

2005 • 29 citations

Acute Interstitial Pneumonia and Acute Exacerbations of Idiopathic Pulmonary Fibrosis

2006 • 29 citations

LU135252, an endothelin_A receptor antagonist did not prevent pulmonary vascular remodelling or lung fibrosis in a rat model of myocardial infarction

2000 • 29 citations

D-Penicillamine Prevents Collagen Accumulation in Lungs of Rats Given Bleomycin

1986 • 29 citations

Efficacy of cyclosporine to reduce steroids in patients with idiopathic pulmonary fibrosis before lung transplantation.

1993 • 29 citations

The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation

1978 • 27 citations

Interferon- γ Upregulates the c-Met/Hepatocyte Growth Factor Receptor Expression in Alveolar Epithelial Cells

1999 • 27 citations

Lung statics and connective tissues after penicillamine in bleomycin-treated hamsters

1980 • 27 citations

Risk of chemotherapy-induced pulmonary fibrosis is associated with polymorphic tumour necrosis factor-a2 gene

2002 • 26 citations

Nonspecific interstitial pneumonia: a real clinical entity?

2004 • 23 citations

Mechanism of Structural Remodeling in Pulmonary Fibrosis

2001 • 23 citations

Regulation of Alveolar Macrophage Production of Chemoattractants by Leukotrine B₄ and Prostaglandin E₂

1991 • 23 citations

The Interstitial Pneumonias

2019 • 22 citations

Pirfenidone in idiopathic pulmonary fibrosis

1999 • 21 citations

Effects of interferons on proliferation and collagen synthesis of rat palatal wound fibroblasts

1999 • 20 citations

Efficacy of cyclosporin A for idiopathic pulmonary fibrosis

1990 • 20 citations

Studies on the endothelin-1-induced contraction of rat granulation tissue pouch mediated by myofibroblasts

1998 • 20 citations

A RANDOMIZED PLACEBO CONTROLLED TRIAL ASSESSING THE EFFICACY AND SAFETY OF ETANERCEPT IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS (IPF)

2005 • 20 citations

Emerging drugs for idiopathic pulmonary fibrosis

2005 • 20 citations

Hypothesis: exposure to solvents may cause fibrosing alveolitis

1994 • 19 citations

Three-dimensional analysis of alveolar structure in usual interstitial pneumonia

2001 • 18 citations

Mediastinal lymphadenopathy in cryptogenic fibrosing alveolitis: the effect of steroid therapy on the prevalence of nodal enlargement

1998 • 17 citations

CXC chemokines in vascular remodeling related to pulmonary fibrosis.

2003 • 16 citations

Idiopathic Pulmonary Fibrosis and Cyclosporine

1998 • 16 citations

Treatment of Idiopathic Pulmonary Fibrosis

2006 • 16 citations

HIGH-RESOLUTION CHEST COMPUTED TOMOGRAPHY FINDINGS DO NOT PREDICT THE PRESENCE OF PULMONARY HYPERTENSION IN ADVANCED IDIOPATHIC PULMONARY FIBROSIS

2007 • 15 citations

Role of clot‐associated (‐derived) thrombin in cell proliferation induced by fibrin clots in vitro

2000 • 15 citations

Host-Environment Interactions in Pulmonary Fibrosis

2006 • 13 citations

Adverse effects of cyclophosphamide in idiopathic pulmonary fibrosis.

1985 • 12 citations

BK and JC Polyomaviruses Are Not Associated with Idiopathic Pulmonary Fibrosis

2005 • 12 citations

Occupational Distribution and Geographic Clustering of Deaths Certified To Be Cryptogenic Fibrosing Alveolitis in England and Wales

2001 • 12 citations

Ultrastructure of terminal respiratory epithelium and prognosis in chronic interstitial pneumonia.

1980 • 10 citations

Genetic Factors in Pulmonary Fibrotic Disorders

2006 • 10 citations

Organization of collagen and other extracellular material in anterior capsular cataract.

1989 • 10 citations

Lower occurrence of idiopathic pulmonary fibrosis in Maori and Pacific Islanders

2006 • 8 citations

Histopathology of Pulmonary Fibrotic Disorders

2006 • 8 citations

Interstitial Pulmonary and Bronchiolar Disorders

2016 • 8 citations

[Elemental analysis of hilar and mediastinal lymph nodes in idiopathic pulmonary fibrosis].

1992 • 6 citations

H2O2 Production by Myofibroblasts Is Dependent on Src Kinase(s) and Actin Cytoskeletal Regulation

2001 • 5 citations

Inherited interstitial lung disease

2004 • 5 citations

Thoracic Imaging for Diffuse ILD and Bronchiolar Disorders

2016 • 4 citations

Idiopathic interstitial pneumonias

2009 • 2 citations

Future Directions in the Treatment of Idiopathic Pulmonary Fibrosis

2003 • 2 citations

Other Imaging Techniques for Idiopathic Interstitial Pneumonias

2003 • 2 citations

Connective-Tissue Disease-Associated Interstitial Lung Disease

2016 • 1 citations

Genetics of ILD

2016 • 1 citations