Diminished Prostaglandin E₂Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

2006 • 1,197 citations

Histopathologic Subsets of Fibrosing Alveolitis in Patients with Systemic Sclerosis and Their Relationship to Outcome

2002 • 784 citations

Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP)

2004 • 418 citations

Fibroblasts and myofibroblasts: Their source, function and role in disease

2006 • 416 citations

The CD95 Receptor: Apoptosis Revisited

2007 • 386 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β₁

1999 • 343 citations

Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?

2007 • 318 citations

Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung

1998 • 291 citations

Induction of Apoptosis and Pulmonary Fibrosis in Mice in Response to Ligation of Fas Antigen

1997 • 289 citations

Prostaglandin E₂Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation

2003 • 282 citations

Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

2001 • 248 citations

Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts

2006 • 235 citations

Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor

2004 • 228 citations

Expression of Apoptotic and Antiapoptotic Markers in Epithelial Cells in Idiopathic Pulmonary Fibrosis

2005 • 222 citations

Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)

2001 • 219 citations

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

2008 • 196 citations

TGF-β1 as an Enhancer of Fas-Mediated Apoptosis of Lung Epithelial Cells

2002 • 192 citations

TNF-α-Induced Cyclooxygenase-2 Expression in Human Lung Epithelial Cells: Involvement of the Phospholipase C-γ2, Protein Kinase C-α, Tyrosine Kinase, NF-κB-Inducing Kinase, and I-κB Kinase 1/2 Pathway

2000 • 190 citations

Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury

1997 • 178 citations

Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor

2001 • 171 citations

Prostaglandin E₂inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling

2006 • 161 citations

Inverse Effects of Interleukin-6 on Apoptosis of Fibroblasts from Pulmonary Fibrosis and Normal Lungs

2003 • 159 citations

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

2004 • 155 citations

Molecular Insights into Mechanisms of the Cell Death Program:Role in the Progression of Neurodegenerative Disorders

2006 • 149 citations

Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro

1995 • 143 citations

Prostaglandin E₂induces fibroblast apoptosis by modulating multiple survival pathways

2009 • 137 citations

Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction

1999 • 133 citations

Augmentation of Functional Prostaglandin E Levels on the Respiratory Epithelial Surface by Aerosol Administration of Prostaglandin E

1991 • 129 citations

Severity of Lung Injury in Cyclooxygenase-2-Deficient Mice Is Dependent on Reduced Prostaglandin E2 Production

2004 • 123 citations

Indomethacin suppresses the anti-proliferative effects of transforming growth factor-β isoforms on fibroblast cell cultures

1997 • 116 citations

Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta.

1997 • 102 citations

Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL‐induced apoptosis

2004 • 95 citations

Primary Human Alveolar Type II Epithelial Cell CCL20 (Macrophage Inflammatory Protein-3α)–Induced Dendritic Cell Migration

2004 • 76 citations

TNF-α Sensitizes Normal and Fibrotic Human Lung Fibroblasts to Fas-Induced Apoptosis

2005 • 73 citations

Apoptotic Activity is Increased in the Newly Formed Fibromyxoid Connective Tissue in Bronchiolitis Obliterans Organizing Pneumonia

1999 • 72 citations

Prostaglandin E₂is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor

2006 • 71 citations

Prosurvival and antiapoptotic effects of PGE₂in radiation injury are mediated by EP₂receptor in intestine

2003 • 66 citations

Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis

2005 • 66 citations

Phosphatidylinositol 3-Kinase/Akt Positively Regulates Fas (CD95)-Mediated Apoptosis in Epidermal Cl41 Cells

2006 • 65 citations

Inflammation and Apoptosis in Clostridium difficile Enteritis Is Mediated by PGE2 Up-Regulation of Fas Ligand

2007 • 64 citations

Times of change

1995 • 56 citations

Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.

2002 • 53 citations

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling

2005 • 43 citations

Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts

2007 • 38 citations

Autocrine/paracrine regulation of apoptosis in epithelial cells by prostaglandin E2

2002 • 14 citations

Basic Science for the Clinician 42

2007 • 9 citations

Loss of Prostaglandin E₂Induced Inhibition of Akt Phosphorylation Contributes to Fibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis (IPF).

2009 • 1 citations