Prostaglandin E₂ Inhibits Fibroblast Migration by E-Prostanoid 2 Receptor–Mediated Increase in PTEN Activity

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000 • 2,535 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

international consensus statement

2000 • 794 citations

Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis

2002 • 755 citations

Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells

2001 • 659 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Prostaglandin E2 Regulates Cell Migration via the Intracellular Activation of the Epidermal Growth Factor Receptor

2003 • 465 citations

PTEN and Myotubularin: Novel Phosphoinositide Phosphatases

2001 • 454 citations

Mechanisms of tissue repair: from wound healing to fibrosis

1997 • 453 citations

Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

1999 • 418 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

1999 • 365 citations

Membrane-binding and activation mechanism of PTEN

2003 • 344 citations

Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

2004 • 338 citations

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

2001 • 313 citations

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

1999 • 312 citations

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

2000 • 291 citations

Prostaglandin E₂Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation

2003 • 282 citations

Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma

2003 • 246 citations

Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades

2003 • 239 citations

Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators.

1986 • 235 citations

Basics of Cutaneous Wound Repair

1993 • 214 citations

Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

2000 • 177 citations

Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction

1999 • 175 citations

Prostaglandin E₂inhibits fibroblast chemotaxis

2001 • 164 citations

Characterization of prostanoid relaxant/inhibitory receptors (ψ) using a highly selective agonist, TR4979

1986 • 149 citations

Prostaglandin E₂Synthesis and Suppression of Fibroblast Proliferation by Alveolar Epithelial Cells Is Cyclooxygenase-2–Dependent

2002 • 149 citations

The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts.

1982 • 147 citations

Integrin α₄β₁ Regulates Migration across Basement Membranes by Lung Fibroblasts

2003 • 138 citations

Augmentation of Functional Prostaglandin E Levels on the Respiratory Epithelial Surface by Aerosol Administration of Prostaglandin E

1991 • 129 citations

Roles of Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways in Stimulation of Vascular Smooth Muscle Cell Migration and Deoxyriboncleic Acid Synthesis by Insulin-Like Growth Factor-I¹

1999 • 117 citations

Indomethacin suppresses the anti-proliferative effects of transforming growth factor-β isoforms on fibroblast cell cultures

1997 • 116 citations

Inhibition of Vascular Smooth Muscle Cell Proliferation, Migration, and Survival by the Tumor Suppressor Protein PTEN

2002 • 106 citations

Enhanced migration of fibroblasts derived from lungs with fibrotic lesions.

1995 • 95 citations

Different Expression of TNF- α Receptors and Prostaglandin E₂Production in Normal and Fibrotic Lung Fibroblasts

2000 • 94 citations

Defect of Hepatocyte Growth Factor Secretion by Fibroblasts in Idiopathic Pulmonary Fibrosis

2003 • 70 citations

Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts.

1998 • 69 citations

Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen α1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts

1998 • 56 citations

Proliferative Characteristics of Fibroblast Lines Derived from Open Lung Biopsy Specimens of Patients with IPF (UIP)

1992 • 43 citations

Roles of Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways in Stimulation of Vascular Smooth Muscle Cell Migration and Deoxyriboncleic Acid Synthesis by Insulin-Like Growth Factor-I

1999 • 19 citations