Role of Transforming Growth Factor β in Human Disease

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Cutaneous Wound Healing

1999 • 5,878 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Cyclosporine induces cancer progression by a cell-autonomous mechanism

1999 • 1,119 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Hereditary Hemorrhagic Telangiectasia

1995 • 1,052 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Genetic control of the circulating concentration of transforming growth factor type beta1

1999 • 749 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

GENOTYPIC VARIATION IN THE TRANSFORMING GROWTH FACTOR-??1 GENE

1998 • 642 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

1996 • 485 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

1996 • 423 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

1999 • 395 citations

Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice

1994 • 363 citations

Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy.

1995 • 334 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Association of a Polymorphism of the Transforming Growth Factor-β1 Gene with Genetic Susceptibility to Osteoporosis in Postmenopausal Japanese Women

1998 • 325 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Association of MSX1 and TGFB3 with Nonsyndromic Clefting in Humans

1998 • 307 citations

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

1999 • 296 citations

Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial

1995 • 284 citations

Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: Evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts

1999 • 252 citations

Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion

1998 • 209 citations

Disruption of the antiproliferative TGF-β signaling pathways in human pancreatic cancer cells

1998 • 190 citations

Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent.

1999 • 190 citations

Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.

1995 • 171 citations

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.

1997 • 171 citations

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

1995 • 162 citations

Role of Transforming Growth Factor-β1 in Invasion and Metastasis in Gastric Carcinoma

1999 • 157 citations

Losartan decreases plasma levels of TGF-β1 in transplant patients with chronic allograft nephropathy

1999 • 152 citations

TGF-β ₁ DNA Polymorphisms, Protein Levels, and Blood Pressure

1999 • 151 citations

Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3.

1994 • 148 citations

Cyclin-Dependent Kinase Regulation during G1 Phase and Cell Cycle Regulation by TGF-ß

1997 • 147 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

Assignment of Transforming Growth Factor β1 and β3 and a Third New Ligand to the Type I Receptor ALK-1

1999 • 144 citations

Elevated serum levels of transforming growth factor-?1 in patients with colorectal carcinoma

1999 • 140 citations

Tamoxifen elevates transforming growth factor–β and suppresses diet–induced formation of lipid lesions in mouse aorta

1995 • 139 citations

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1995 • 131 citations

Tamoxifen: Teaching an old drug new tricks?

1996 • 123 citations

Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target?

1997 • 122 citations

Reduced plasma transforming growth factor-β1 levels in patients with chronic hepatitis C after interferon-α therapy: association with regression of hepatic fibrosis

1999 • 121 citations

Cellular and extracellular biology of the latent transforming growth factor-β binding proteins

1998 • 104 citations

TGF-?1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis

1999 • 103 citations

Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo

1997 • 102 citations

A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1.

1998 • 99 citations

Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles

1998 • 98 citations

The Viral Oncoprotein E1A Blocks Transforming Growth Factor β-Mediated Induction of p21/WAF1/Cip1 and p15/INK4B

1997 • 97 citations

A major advance in the use of growth factors to enhance wound healing.

1993 • 95 citations

Transforming growth factor-β1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity

1998 • 84 citations

SERUM TRANSFORMING GROWTH FACTOR-??1 LEVELS IN BONE MARROW TRANSPLANT RECIPIENTS CORRELATE WITH BLOOD CELL COUNTS AND CHRONIC GRAFT-VERSUS-HOST DISEASE1

1999 • 82 citations

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers

1998 • 82 citations

The Expression of TGF-β Receptors in Human Atherosclerosis: Evidence for Acquired Resistance to Apoptosis due to Receptor Imbalance

1999 • 80 citations

Transforming growth factor β and cancer

1995 • 73 citations

Persistent Transforming Growth Factor-Beta 1 Expression May Predict Peritoneal Fibrosis in CAPD Patients with Frequent Peritonitis Occurrence

1998 • 58 citations

PEAKS OF TRANSFORMING GROWTH FACTOR-?? mRNA IN ALVEOLAR CELLS OF LUNG TRANSPLANT RECIPIENTS AS AN EARLY MARKER OF CHRONIC REJECTION

1998 • 58 citations

Transforming growth factor beta 2 (TGF-beta 2) levels in plasma of patients with metastatic breast cancer treated with tamoxifen.

1995 • 54 citations

Elevated urinary transforming growth factor-β1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma

1997 • 53 citations

Plasma transforming growth factor‐β1 concentrations in patients with chronic viral hepatitis

1998 • 43 citations

Transforming growth factor β1 (TGF-β1) is a preoperative prognostic indicator in advanced gastric carcinoma

1998 • 35 citations

Combination of Bone Marrow and TGF-β1 Augment the Healing of Critical-Sized bone Defects

1998 • 35 citations

Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene.

1997 • 23 citations