Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1979 • 27,693 citations

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1961 • 3,860 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases.

1981 • 344 citations

A rapid assay for collagen proline hydroxylase

1966 • 333 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.

1979 • 306 citations

Collagen polymorphism in idiopathic chronic pulmonary fibrosis.

1976 • 264 citations

Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters.

1995 • 213 citations

Formation of superoxide and hydroxy radicals in iron(II)-bleomycin-oxygen system: Electron spin resonance detection by spin trapping.

1978 • 175 citations

Prolyl 4-hydroxylase and its role in collagen synthesis

1991 • 161 citations

Profiles of steady state levels of messenger RNAs coding for type I procollagen, elastin, and fibronectin in hamster lungs undergoing bleomycin-induced interstitial pulmonary fibrosis.

1985 • 131 citations

Lung Fibrosis is Ameliorated by Pirfenidone Fed in Diet After the Second Dose In A Three-Dose Bleomycin-Hamster Model

1998 • 104 citations

Protein Metabolism during Bleomycin-induced Pulmonary Fibrosis in Rabbits

1983 • 100 citations

Collagen biosynthesis in bleomycin-induced pulmonary fibrosis in hamsters.

1980 • 90 citations

Fibrotic Reactions in the Lung: The Activation of the Lung Fibroblast

1986 • 88 citations

Molecular Biology of Prolyl 4‐Hydroxylase

1990 • 85 citations

Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters

1983 • 85 citations

Approaches to the treatment of pulmonary fibrosis.

1995 • 81 citations

Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice

1997 • 75 citations

New perspectives on basic mechanisms in lung disease. 1. Lung injury, inflammatory mediators, and fibroblast activation in fibrosing alveolitis.

1992 • 68 citations

Increases in lung prolyl hydroxylase and superoxide dismutase activities during bleomycin-induced lung fibrosis in hamsters

1983 • 64 citations

Biochemical and structural alterations of hamster lungs in response to intratracheal administration of bleomycin

1980 • 59 citations

On the mechanism of hydrogen peroxide-, superoxide-, and ultraviolet light-induced DNA cleavages of inactive bleomycin-iron(III) complex

1982 • 56 citations

Analysis of Bronchoalveolar Lavage Fluid from Bleomycin-Induced Pulmonary Fibrosis in Hamsters

1986 • 52 citations

Effect of DNA on the production of reduced oxygen by bleomycin and iron

1982 • 52 citations

Evaluation of antifibrotic drugs in bleomycin-induced pulmonary fibrosis in hamsters.

1980 • 49 citations

Bleomycin stimulates pro-alpha 1 (I) collagen promoter through transforming growth factor beta response element by intracellular and extracellular signaling.

1994 • 47 citations

Fibrotic lung disease--a perspective.

1980 • 45 citations

Novel inhibitors of prolyl 4-hydroxylase

1992 • 40 citations

Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis.

1996 • 35 citations

Interstitial lung disease.

1991 • 29 citations