Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

1993 • 708 citations

Prostaglandin endoperoxide synthase: structure and catalysis

1991 • 607 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

1983 • 308 citations

Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

1980 • 282 citations

A Clinical, Radiographic, and Physiologic Scoring System for the Longitudinal Assessment of Patients with Idiopathic Pulmonary Fibrosis^1–3

1986 • 269 citations

Cytokine Networks in the Regulation of Inflammation and Fibrosis in the Lung

1990 • 266 citations

Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators.

1986 • 235 citations

Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen.

1980 • 178 citations

Cytokines and pulmonary fibrosis.

1993 • 172 citations

Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.

1993 • 171 citations

Pulmonary Fibroblast Expression of Interleukin-8: A Model for Alveolar Macrophage-derived Cytokine Networking

1991 • 153 citations

The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts.

1982 • 147 citations

Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: effect of indomethacin.

1987 • 135 citations

Augmentation of Functional Prostaglandin E Levels on the Respiratory Epithelial Surface by Aerosol Administration of Prostaglandin E

1991 • 129 citations

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

1992 • 129 citations

Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process.

1985 • 110 citations

Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products.

1983 • 106 citations

Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.

1992 • 97 citations

Tumor Necrosis Factor Interacts with Interleukin-1 and Interferons to Inhibit Fibroblast Proliferation via Fibroblast Prostaglandin-dependent and -independent Mechanisms

1988 • 96 citations

Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung.

1990 • 92 citations

Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene.

1994 • 90 citations

Fibrotic Reactions in the Lung: The Activation of the Lung Fibroblast

1986 • 88 citations

Inhibition of the transendothelial migration of human T lymphocytes by prostaglandin E2.

1994 • 86 citations

Arachidonic acid metabolism by cells in culture: analyses of culture fluids for cyclooxygenase products by radioimmunoassay before and after separation by high pressure liquid chromatography

1979 • 77 citations

Characterization of lipoxygenase metabolites of arachidonic acid in cultured human skin fibroblasts

1984 • 55 citations

Effects of Platelet-Derived Growth Factor Isoforms on Human Lung Fibroblast Proliferation and Procollagen Gene Expression

1993 • 47 citations

Arachidonic acid level in cellular lipids determines the amount of prostaglandins synthesized during cell growth in tissue culture

1979 • 38 citations

Alveolar Macrophage/Peripheral Blood Monocyte-Derived Factors Modulate Proliferation of Primary Lines of Human Lung Fibroblasts

1987 • 36 citations

[32] Characteristics of rabbit anti-PGH synthase antibodies and use in immunocytochemistry

1982 • 30 citations

Alterations in prostaglandin synthesis during senescence of human lung fibroblasts

1980 • 25 citations

Rapid quantification of 11 prostanoids by combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry: Application to prostanoids released from normal human embryonic lung fibroblasts WI38 in a culture medium

1988 • 21 citations

Regulation of oxygen radical release from murine peritoneal macrophages by pharmacologic doses of PGE2

1987 • 19 citations