Copper Control as an Antiangiogenic Anticancer Therapy: Lessons from Treating Wilson's Disease

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Angiogenic Factors

1987 • 3,702 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Angiogenesis.

1992 • 2,581 citations

Undetectable Intracellular Free Copper: The Requirement of a Copper Chaperone for Superoxide Dismutase

1999 • 1,573 citations

Cancer: Principles and Practice of Oncology

1997 • 1,408 citations

Anti-Angiogenesis

1972 • 1,167 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Role of vascular endothelial growth factor in the regulation of angiogenesis

1999 • 733 citations

A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution

1999 • 715 citations

Penicillamine, a new oral therapy for Wilson's disease

1956 • 694 citations

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.

1994 • 407 citations

Role of prostaglandin E1 and copper in angiogenesis.

1982 • 393 citations

TREATMENT OF WILSON'S DISEASE WITH TRIENTINE (TRIETHYLENE TETRAMINE) DIHYDROCHLORIDE

1982 • 369 citations

Evidence for Cu(II) Reduction as a Component of Copper Uptake by Saccharomyces cerevisiae

1995 • 357 citations

Mechanisms of Angiogenesis in the Brain

1999 • 352 citations

Worsening of Neurologic Syndrome in Patients With Wilson's Disease With Initial Penicillamine Therapy

1987 • 329 citations

Major Problems in Internal Medicine

1978 • 305 citations

Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study.

2000 • 300 citations

Treatment of Wilson Disease With Ammonium Tetrathiomolybdate

2003 • 298 citations

Wilson Disease

1992 • 297 citations

Human Vascular Permeability Factor

1989 • 282 citations

Treatment of Wilson's disease with zinc: XV long-term follow-up studies

1998 • 264 citations

Trace element metabolism in man and animals - 3.

1978 • 255 citations

Copper-specific Transcriptional Repression of Yeast Genes Encoding Critical Components in the Copper Transport Pathway

1997 • 249 citations

SPARC is a source of copper-binding peptides that stimulate angiogenesis.

1994 • 247 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Trace Element Metabolism in Man and Animals

1982 • 228 citations

Ceruloplasmin, Copper Ions, and Angiogenesis<xref ref-type="fn" rid="fn2">2</xref>

1982 • 226 citations

Recognition, Diagnosis, and Management of Wilson's Disease

2000 • 188 citations

Initial Therapy of Patients With Wilson's Disease With Tetrathiomolybdate

1991 • 187 citations

Homeostatic Regulation of Copper Uptake in Yeast via Direct Binding of MAC1 Protein to Upstream Regulatory Sequences ofFRE1 and CTR1

1997 • 180 citations

Copper in the Environment Copper in the Environment: Part 1: Ecological Cycling Jerome O. Nriagu

1983 • 171 citations

Treatment of Wilson's Disease With Ammonium Tetrathiomolybdate

1994 • 161 citations

Thiomolybdates and the copper–molybdenum–sulphur interaction in ruminant nutrition

1975 • 159 citations

The teart pastures of Somerset: I. The cause and cure of teartness

1943 • 155 citations

Treatment of Wilson's disease with zinc: X. Intestinal metallothionein induction.

1992 • 146 citations

Angiogenesis and Cancer Control: From Concept to Therapeutic Trial

1999 • 134 citations

Treatment of Wilson Disease With Ammonium Tetrathiomolybdate

1996 • 134 citations

Interaction of Human Angiogenin with Copper Modulates Angiogenin Binding to Endothelial Cells

1997 • 129 citations

Evidence for the Saccharomyces cerevisiae Ferrireductase System Being a Multicomponent Electron Transport Chain

1996 • 110 citations

Inactivation of human fibroblast growth factor-1 (FGF-1) activity by interaction with copper ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation.

1992 • 108 citations

SOME PRELIMINARY OBSERVATIONS ON THE EFFECT OF MOLYBDENUM ON COPPER METABOLISM IN HERBIVOROUS ANIMALS

1945 • 101 citations

Factors Promoting Tumor Angiogenesis

1999 • 98 citations

Characterization and quantification of copper sulfate-induced vascularization of the rabbit cornea.

1988 • 90 citations

Copper in the Environment, Part II: Health Effects

1981 • 82 citations

Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea

1997 • 78 citations

Altered distribution of copper (64Cu) in tumor-bearing mice and rats.

1986 • 76 citations

Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain

1990 • 75 citations

Effects of molybdate, sulfide, and tetrathiomolybdate on copper metabolism in rats

1981 • 74 citations

Copper concentration and cytochrome-oxidase and ribonuclease activities in the brains of copper-deficient lambs

1962 • 71 citations

Copper Regulation of Ceruloplasmin in Copper-Deficient Rats

1979 • 71 citations

GRISEA, a copper-modulated transcription factor from Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae

1998 • 71 citations

Purified monocyte‐derived angiogenic substance (angiotropin) stimulates migration, phenotypic changes, and “tube formation” but not proliferation of capillary endothelial cells in vitro

1987 • 68 citations

GRISEA, a putative copper-activated transcription factor fromPodospora anserina involved in differentiation and senescence

1996 • 64 citations

Anticopper Treatment Inhibits Pseudopodial Protrusion and the Invasive Spread of 9L Gliosarcoma Cells in the Rat Brain

1990 • 59 citations

Vascular Endothelial Growth Factor: An Important Angiogenic Mediator in Bladder Cancer

1999 • 51 citations

THE PATHOGENESIS OF “FALLING DISEASE.”

1948 • 50 citations

A comparison of the effects of Penicillamine, Trientine, and trithiomolybdate on [35S]-labeled metallothionein in vitro; implications for Wilson's disease therapy

1991 • 45 citations

An overview of clinical trials involving inhibitors of angiogenesis and their mechanism of action

1997 • 45 citations

Gangliosides, copper ions and angiogenic capacity of adult tissues

1990 • 39 citations

Deficiências e desequilíbrios minerais em bovinos e ovinos <FONT FACE=Symbol>¾</FONT> revisão dos estudos realizados no Brasil de 1987 a 1998

1999 • 37 citations

A NATURAL COPPER DEFICIENCY IN CATTLE RATIONS

1931 • 32 citations

Growth factor release from amylopectin hydrogel based on copper coordination

1998 • 31 citations

Quantitative and histochemical analysis of Cu, Zn, and Fe in spontaneous and induced primary tumors of rats.

1961 • 30 citations

Localization of Tissue Copper in Mouse Mammary Tumors

1989 • 30 citations

Interrelations of copper, molybdenum and sulfate sulfur in nutrition.

1960 • 28 citations

Pathophysiology of tumor angiogenesis and its relevance in renal cell cancer.

1999 • 25 citations

Metal concentrations in chrionomids in relation to peatland geochemistry

1994 • 22 citations

Copper transport and its disorders : molecular and cellular aspects

1999 • 22 citations

Copper-Regulatory Domain Involved in Gene Expression

1999 • 20 citations

Histopathology of Enzootic Ataxia in Sika deer(Cervus nippon Temminck).

1996 • 14 citations

Composição mineral das pastagens das regiões norte e noroeste do Estado do Rio de Janeiro: 2. Manganês, ferro, zinco, cobre, cobalto, molibdênio e chumbo

2000 • 11 citations

Trace Element Metabolism in Man and Animals. 3. Proceedings of the 3rd International Symposium, Freising. BRD. 1977. Herausgegeben von M. Kirchgessner. 684 Seiten, zahlreiche Abb. und Tab. Institut für Ernärungsphysiologie. Technische Universität München. Freising‐Weihenstephan 1978

1980 • 3 citations

Deleted Work

1955 • 0 citations