Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1

Collagen Metabolism in Cultured Adult Rat Cardiac Fibroblasts: Response to Angiotensin II and Aldosterone

1994 • 679 citations

Remodeling of the rat right and left ventricles in experimental hypertension.

1990 • 676 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle.

1989 • 500 citations

Mineralocorticoids, hypertension, and cardiac fibrosis.

1994 • 440 citations

Myocardial Fibrosis and Stiffness With Hypertrophy and Heart Failure in the Spontaneously Hypertensive Rat

1995 • 436 citations

Endothelin-1 Is Involved in Mechanical Stress-induced Cardiomyocyte Hypertrophy

1996 • 400 citations

Activation of Cardiac Aldosterone Production in Rat Myocardial Infarction

1999 • 375 citations

Growth factor activity of endothelin on vascular smooth muscle

1990 • 325 citations

Remodeling and reparation of the cardiovascular system

1992 • 323 citations

Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells.

1994 • 314 citations

Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor.

1992 • 305 citations

Effects of endothelins on collagen turnover in cardiac fibroblasts

1993 • 290 citations

Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.

1994 • 286 citations

Prerequisite for Cardiac Aldosterone Action

1995 • 286 citations

Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats.

1993 • 278 citations

Reactive and reparative myocardial fibrosis in arterial hypertension in the rat

1992 • 268 citations

Determinants of cardiac fibrosis in experimental hypermineralocorticoid states

1995 • 234 citations

Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion

1997 • 228 citations

Angiotensin II–Induced Growth Responses in Isolated Adult Rat Hearts

1995 • 200 citations

Production of Aldosterone in Isolated Rat Blood Vessels

1995 • 173 citations

Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts

1996 • 159 citations

Myocardial Fibrosis in DOCA-Salt Hypertensive Rats

2001 • 153 citations

Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo

1996 • 144 citations

Left Ventricular Fibrosis in Renovascular Hypertensive Rats

1995 • 125 citations

Structure and Function of Small Arteries in Salt-Induced Hypertension

1997 • 124 citations

ET _A Receptor Antagonist Prevents Blood Pressure Elevation and Vascular Remodeling in Aldosterone-Infused Rats

2001 • 121 citations

Myocardial Fibrosis in the Rat With Mineralocorticoid Excess Prevention of Scarring by Amiloride

1993 • 80 citations

Increased endothelium-1 gene expression in the endothelium of coronary arteries and endocardium in the DOCA-salt hypertensive rat

1995 • 77 citations

Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats

1996 • 75 citations

In situ hybridization shows increased endothelin-1 mRNA levels in endothelial cells of blood vessels of deoxycorticosterone acetate-salt hypertensive rats

1995 • 75 citations

Prolonged endothelin blockade prevents hypertension and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats

1995 • 52 citations

Effects of AT₁ receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility

1999 • 47 citations

Effect of Vasopressin Antagonism on Structure and Mechanics of Small Arteries and Vascular Expression of Endothelin-1 in Deoxycorticosterone Acetate–Salt Hypertensive Rats

1998 • 44 citations

The cardiac structure-function relationship and the renin-angiotensin-aldosterone system in hypertension and heart failure

1994 • 41 citations

Cardiac Microvasculature in DOCA-Salt Hypertensive Rats

1999 • 36 citations

Vascular binding sites and biological activity of vasopressin in DOCA-salt hypertensive rats

1988 • 29 citations

Introduction

1994 • 2 citations