Rho‐dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

Current Perspectives on Statins

2000 • 1,220 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

1997 • 743 citations

The CCN Family of Angiogenic Regulators: The Integrin Connection

1999 • 656 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

The modular architecture of a new family of growth regulators related to connective tissue growth factor

1993 • 634 citations

Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

1999 • 623 citations

Expression of connective tissue growth factor in human renal fibrosis

1998 • 545 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Suppression Subtractive Hybridization Identifies High Glucose Levels as a Stimulus for Expression of Connective Tissue Growth Factor and Other Genes in Human Mesangial Cells

1999 • 395 citations

Inhibition of Geranylgeranylation Reduces Angiotensin II-Mediated Free Radical Production in Vascular Smooth Muscle Cells: Involvement of Angiotensin AT1 Receptor Expression and Rac1 GTPase

2001 • 350 citations

Cell cycle-specific effects of lovastatin.

1991 • 301 citations

Human Connective Tissue Growth Factor Is Expressed in Advanced Atherosclerotic Lesions

1997 • 301 citations

Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis

2000 • 290 citations

Suppression of Endothelial Nitric Oxide Production After Withdrawal of Statin Treatment Is Mediated by Negative Feedback Regulation of Rho GTPase Gene Transcription

2000 • 272 citations

Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types

1997 • 218 citations

Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway.

1997 • 194 citations

Clinical Pharmacokinetics of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors

1996 • 168 citations

Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

1998 • 156 citations

The role of lipids in renal disease: Future challenges

2000 • 133 citations

Expression of Connective Tissue Growth Factor in Human Renal Fibroblasts

2001 • 130 citations

Induction of Connective Tissue Growth Factor by Activation of Heptahelical Receptors

2000 • 108 citations

Lovastatin Inhibits Transforming Growth Factor-β1 Expression in Diabetic Rat Glomeruli and Cultured Rat Mesangial Cells

2000 • 97 citations

Functional Differences in the Interaction of Arrestin and Its Splice Variant, p⁴⁴, with Rhodopsin

1997 • 94 citations

Lovastatin reduces glomerular macrophage influx and expression of monocyte chemoattractant protein-1 mRNA in nephrotic rats

1998 • 89 citations

Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells.

1994 • 77 citations

Transforming Growth Factor-β in Renal Disease

1998 • 76 citations

Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton.

1997 • 75 citations

Human mesangial cell production of monocyte chemoattractant protein-1: Modulation by lovastatin

1995 • 72 citations

Lovastatin modulates in vivo and in vitro the plasminogen activator/plasmin system of rat proximal tubular cells

1998 • 71 citations

Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21 activated, AP-1-dependent pathway

1997 • 70 citations

Low-Density Lipoprotein-Induced Expression of Interleukin-6, a Marker of Human Mesangial Cell Inflammation: Effects of Oxidation and Modulation by Lovastatin

2000 • 69 citations

Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to investigate pathophysiologic mechanisms of renal interstitial fibrosis.

1995 • 68 citations

Defined daily doses in relation to hypolipidaemic efficacy of lovastatin, pravastatin, and simvastatin

1994 • 67 citations

Connective Tissue Growth Factor Expression in the Rat Remnant Kidney Model and Association with Tubular Epithelial Cells Undergoing Transdifferentiation

2000 • 66 citations

TGF-β1 Stimulation of Fibronectin Transcription in Cultured Human Lung Fibroblasts Requires Active Geranylgeranyl Transferase I, Phosphatidylcholine-Specific Phospholipase C, Protein Kinase C-δ, and p38, But Not erk1/erk2

2000 • 59 citations

Effect of HMG-CoA reductase inhibitors on extracellular matrix expression in human vascular smooth muscle cells

1999 • 57 citations

Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design.

1997 • 44 citations

Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts

2000 • 44 citations

The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells

2000 • 42 citations

Prevention of progression of renal fibrosis: how far are we?

1996 • 28 citations

Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I

2000 • 27 citations

G-Protein-Mediated Signaling in Cholesterol-Enriched Arterial Smooth Muscle Cells. 1. Reduced Membrane-Associated G-Protein Content Due to Diminished Isoprenylation of G-γ Subunits and p21ras

1997 • 24 citations

Inhibition of Protein Isoprenylation Impairs Rho-Regulated Early Cellular Response to Genotoxic Stress

2000 • 24 citations

In vitro effects of simvastatin on tubulointerstitial cells in a human model of cyclosporin nephrotoxicity

1999 • 16 citations

Effect of lipid-lowering strategies on tubular cell biology

1999 • 10 citations

The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells

2000 • 10 citations