Endothelin A Receptor Blockade Decreases Expression of Growth Factors and Collagen and Improves Matrix Metalloproteinase-2 Activity in Kidneys from Stroke-Prone Spontaneously Hypertensive Rats

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

1997 • 406 citations

Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.

1991 • 360 citations

Salt Induces Myocardial and Renal Fibrosis in Normotensive and Hypertensive Rats

1998 • 340 citations

Angiotensin II Increases Tissue Endothelin and Induces Vascular Hypertrophy

1997 • 329 citations

Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.

1994 • 286 citations

Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats.

1993 • 278 citations

Endothelin: Potential Role in Hypertension and Vascular Hypertrophy

1995 • 240 citations

Role of Endothelin-1 in Hypertension

1999 • 193 citations

Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats.

1993 • 163 citations

Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats.

1995 • 146 citations

Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats.

1989 • 143 citations

Effect of different endothelin receptor antagonists and of the novel non‐peptide antagonist Ro 46‐2005 on endothelin levels in rat plasma

1993 • 122 citations

Deoxycorticosterone Acetate Plus Salt Induces Overexpression of Vascular Endothelin-1 and Severe Vascular Hypertrophy in Spontaneously Hypertensive Rats

1995 • 115 citations

Effect of a specific endothelin A receptor antagonist on murine lupus nephritis

1995 • 114 citations

Sodium-lithium countertransport

1998 • 92 citations

Effects of Transforming Growth Factor-β1 on Renal Extracellular Matrix Components and Their Regulating Proteins

1999 • 80 citations

Endothelin Antagonism in End-Organ Damage of Spontaneously Hypertensive Rats

1996 • 74 citations

Cloning and function expression of human endothelin-1 receptor cDNA

1991 • 72 citations

Effect of chronic ET_A‐selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats

1997 • 64 citations

Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension

1996 • 60 citations

Endothelin A receptor blockade alleviates hypertension and renal lesions associated with chronic nitric oxide synthase inhibition.

1998 • 59 citations

Endothelin Antagonists in Salt-Dependent Hypertension Associated with Renal Insufficiency

1996 • 54 citations

Nephroprotection of an ET _A -Receptor Blocker (LU 135252) in Salt-Loaded Uninephrectomized Stroke-Prone Spontaneously Hypertensive Rats

1998 • 53 citations

Early-Onset But Not Late-Onset Endothelin-A–Receptor Blockade Can Modulate Hypertension, Cerebral Edema, and Proteinuria in Stroke-Prone Hypertensive Rats

1999 • 50 citations

Collagen I and III and Mechanical Properties of Conduit Arteries in Rats with Genetic Hypertension

1999 • 45 citations

Renal and vascular effects of chronic endothelin receptor antagonism in malignant hypertensive rats

1996 • 40 citations

Vascular Endothelin-1 Expression and Effect of an Endothelin ETA Antagonist on Structure and Function of Small Arteries from Stroke-Prone Spontaneously Hypertensive Rats

1998 • 33 citations

Changes in transforming growth factor-beta (TGF-beta1), procollagen types I and III mRNA in the rat heart after irradiation

1999 • 33 citations

Antihypertensive effects of BQ-123, a selective endothelin ETA receptor antagonist, in spontaneously hypertensive rats treated with DOCA-salt

1994 • 28 citations

EFFECTS OF A SELECTIVE ENDOTHELIN A‐RECEPTOR ANTAGONIST, BQ‐123, IN SALT‐LOADED STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

1995 • 24 citations

Antihypertensive Effects of a Mixed Endothelin-A- and -B-Receptor Antagonist, J-104132, Were Augmented in the Presence of an AT1-Receptor Antagonist, MK-954

2000 • 23 citations

Endothelin-A-Receptor Blockade Improves Renal Function and Doubles the Lifespan of Stroke-Prone Spontaneously Hypertensive Rats

2000 • 18 citations

[Role of matrix metalloproteinases in the progression of renal lesions].

2000 • 17 citations

Inhibition by Lacidipine of Salt-Dependent Cardiac Hypertrophy and Endothelin Gene Expression in Stroke-Prone Spontaneously Hypertensive Rats

1995 • 16 citations

Prolonged Endothelin Blockade Reduces Hypertension and Cardiac Hypertrophy in SHR-SP

1995 • 11 citations