Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

The protein kinase B/Akt signalling pathway in human malignancy

2002 • 1,609 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

2001 • 1,152 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

PI3K/Akt and apoptosis: size matters

2003 • 1,125 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Fibroblast biology in three-dimensional collagen matrices

2003 • 809 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

The extracellular matrix as a scaffold for tissue reconstruction

2002 • 793 citations

A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization- mass spectrometry

2000 • 711 citations

Endothelins

1995 • 682 citations

Paxillin: a focal adhesion-associated adaptor protein

2001 • 520 citations

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

2002 • 455 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

2001 • 419 citations

Mechanisms of force generation and transmission by myofibroblasts

2003 • 399 citations

Clinical deterioration in patients with idiopathic pulmonary fibrosis: Causes and assessment

1990 • 368 citations

ERM proteins: From cellular architecture to cell signaling

2000 • 311 citations

Connective Tissue Growth Factor Gene Regulation

2003 • 301 citations

Factors influencing myofibroblast differentiation during wound healing and fibrosis.

1995 • 273 citations

Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction

1990 • 266 citations

Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1

2001 • 241 citations

Molecular pharmacology of endothelin converting enzymes

1996 • 239 citations

Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis.

2000 • 227 citations

The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

2002 • 226 citations

Invited Review: Cross-bridge regulation by thin filament-associated proteins

2001 • 221 citations

Mechanical Properties of the Extracellular Matrix Influence Fibronectin Fibril Assembly in Vitro

1995 • 213 citations

Endothelins ¹

1991 • 213 citations

Akt signaling in skeletal muscle: regulation by exercise and passive stretch

2003 • 209 citations

Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease.

1997 • 206 citations

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

1998 • 206 citations

Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing.

1996 • 198 citations

A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling

1994 • 197 citations

Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology

1996 • 196 citations

Thrombin Differentiates Normal Lung Fibroblasts to a Myofibroblast Phenotype via the Proteolytically Activated Receptor-1 and a Protein Kinase C-dependent Pathway

2001 • 192 citations

PATHOGENESIS OF SCLERODERMA

1996 • 178 citations

Autocrine Overexpression of CTGF Maintains Fibrosis: RDA Analysis of Fibrosis Genes in Systemic Sclerosis

2000 • 178 citations

Differences in the Regulation of Fibroblast Contraction of Floating Versus Stressed Collagen Matrices

1999 • 177 citations

The role of integrin-linked kinase (ILK) in cancer progression.

2003 • 173 citations

β1 Integrin Regulates Fibroblast Viability during Collagen Matrix Contraction through a Phosphatidylinositol 3-Kinase/Akt/Protein Kinase B Signaling Pathway

2002 • 163 citations

Significance of plasma endothelin-1 levels in patients with systemic sclerosis.

1992 • 158 citations

Myofibroblasts from Scleroderma Skin Synthesize Elevated Levels of Collagen and Tissue Inhibitor of Metalloproteinase (TIMP-1) with Two Forms of TIMP-1

1995 • 153 citations

Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma.

1995 • 153 citations

Prostacyclin derivatives prevent the fibrotic response to TGFβ2 by inhibiting the Ras/MEK/ERK pathway

2002 • 145 citations

Insights Into the Molecular Mechanism of Chronic Fibrosis: The Role of Connective Tissue Growth Factor in Scleroderma

2004 • 135 citations

Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. OFF.

1993 • 134 citations

Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane

2004 • 128 citations

Modulation of contraction by gelation/solation in a reconstituted motile model.

1991 • 112 citations

A Cytokine Reborn?

2000 • 112 citations

Transforming Growth Factor β Stimulates Fibroblast–Collagen Matrix Contraction by Different Mechanisms in Mechanically Loaded and Unloaded Matrices

2002 • 112 citations

Mediation of Transforming Growth Factor-β1-Stimulated Matrix Contraction by Fibroblasts

2003 • 111 citations

The Role of the Myofibroblast in Wound Healing and Fibrocontractive Diseases

1988 • 107 citations

Dysregulation of transforming growth factor β signaling in scleroderma: Overexpression of endoglin in cutaneous scleroderma fibroblasts

2002 • 104 citations

Smooth muscle differentiation in scleroderma fibroblastic cells.

1990 • 101 citations

Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis.

1994 • 100 citations

Pulmonary fibrosis: Cellular and molecular events

2003 • 97 citations

Functional Cooperation Between Smad Proteins and Activator Protein-1 Regulates Transforming Growth Factor-β–Mediated Induction of Endothelin-1 Expression

2003 • 95 citations

Effect of endothelin-1 on α-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases

1999 • 87 citations

Endothelins: Effect on Matrix Biosynthesis and Proliferation in Normal and Scleroderma Fibroblasts

1998 • 82 citations

On the mechanism of skin wound "contraction": a granulation tissue "knockout" with a normal phenotype.

1995 • 80 citations

Contractile activity and smooth muscle α-actin organization in thrombin-induced human lung myofibroblasts

2003 • 69 citations

Endothelins produced by endothelial cells promote collagen gel contraction by fibroblasts.

1991 • 68 citations

Regulation of Connective Tissue Synthesis in Systemic Sclerosis

1995 • 61 citations

Impaired Regulation of Collagen Pro-∝1(I) mRNA and Change in Pattern of Collagen-Binding Integrins on Scleroderma Fibroblasts

1993 • 60 citations

Effect of endothelin-1 on croton oil-induced granulation tissue in the rat. A pharmacologic and immunohistochemical study.

1992 • 51 citations

Role of connective tissue proteases in the pathogenesis of chronic inflammatory lung disease.

1984 • 48 citations

Cell and Molecular Regulation of Endothelin-1 Production during Hepatic Wound Healing

2003 • 46 citations

PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways

2001 • 46 citations

Fibroblast Quiescence in Floating Collagen Matrices

2003 • 45 citations

Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs

1994 • 45 citations

Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis

1997 • 44 citations

Epidermal growth factor induces acute matrix contraction and subsequent calpain‐modulated relaxation

2002 • 44 citations

Smad3 mediates the TGF‐β‐induced contraction of type I collagen gels by mouse embryo fibroblasts

2003 • 41 citations

Fibroblasts contracting collagen matrices form transient plasma membrane passages through which the cells take up fluorescein isothiocyanate-dextran and Ca2+.

1997 • 39 citations

Affinity and selectivity of PD156707, a novel nonpeptide endothelin antagonist, for human ET(A) and ET(B) receptors.

1997 • 37 citations

Mitogenic activity of endothelin on human cultured prostatic smooth muscle cells

1998 • 31 citations

Collagen Synthesis and Degradation by Systemic Sclerosis Lung Fibroblasts

1991 • 24 citations

Scleroderma: A disease related to damaged proteins?

1997 • 22 citations

Endothelins.

1990 • 5 citations

Expression of endothelin and ETB receptors in the megakaryoblastic MEG-01 cell line.

1995 • 4 citations

Expression of Endothelin and ETB Receptors in the Megakaryoblastic MEG-01 Cell Line

1995 • 3 citations

Endothelins

1990 • 1 citations

Deleted Work

1955 • 0 citations