Idiopathic Pulmonary Fibrosis

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

2002 • 5,594 citations

American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias

2002 • 3,947 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

2001 • 2,653 citations

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000 • 2,535 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects

2003 • 1,405 citations

Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial

2002 • 1,272 citations

Idiopathic Pulmonary Fibrosis

1998 • 1,255 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis

1998 • 1,037 citations

Idiopathic Pulmonary Fibrosis

2001 • 956 citations

The epidemiology of interstitial lung diseases.

1994 • 912 citations

Treatment of Asthma with Drugs Modifying the Leukotriene Pathway

1999 • 825 citations

Predicting Survival in Idiopathic Pulmonary Fibrosis

2001 • 822 citations

Natural History and Treated Course of Usual and Desquamative Interstitial Pneumonia

1978 • 802 citations

Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

2001 • 768 citations

Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis.

1997 • 707 citations

Idiopathic Pulmonary Fibrosis

1976 • 706 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Histopathologic Variability in Usual and Nonspecific Interstitial Pneumonias

2001 • 652 citations

A Placebo-Controlled Trial of Interferon Gamma-1b in Patients with Idiopathic Pulmonary Fibrosis

2004 • 643 citations

Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial

2002 • 639 citations

Idiopathic Pulmonary Fibrosis

2001 • 628 citations

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

2002 • 600 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Bone marrow-derived cells as progenitors of lung alveolar epithelium

2001 • 555 citations

Utility of a Lung Biopsy for the Diagnosis of Idiopathic Pulmonary Fibrosis

2001 • 553 citations

Leukotriene E4 and granulocytic infiltration into asthmatic airways

1993 • 537 citations

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

1999 • 532 citations

Idiopathic Nonspecific Interstitial Pneumonia: Prognostic Significance of Cellular and Fibrosing Patterns

2000 • 527 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

The Prognostic Significance of the Histologic Pattern of Interstitial Pneumonia in Patients Presenting with the Clinical Entity of Cryptogenic Fibrosing Alveolitis

2000 • 492 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

An Immunohistochemical Study of Architectural Remodeling and Connective Tissue Synthesis in Pulmonary Fibrosis

1989 • 469 citations

Treatment of Idiopathic Pulmonary Fibrosis with a New Antifibrotic Agent, Pirfenidone

1999 • 465 citations

Mechanisms for pro matrix metalloproteinase activation

1999 • 436 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors

2002 • 422 citations

Azathioprine Combined with Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis: A Prospective Double-blind, Randomized, Placebo-controlled Clinical Trial

1991 • 416 citations

TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

2000 • 412 citations

The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.

1991 • 406 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Inhaled Prostacyclin and Iloprost in Severe Pulmonary Hypertension Secondary to Lung Fibrosis

1999 • 399 citations

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

1998 • 395 citations

A Histologic Pattern of Nonspecific Interstitial Pneumonia Is Associated with a Better Prognosis Than Usual Interstitial Pneumonia in Patients with Cryptogenic Fibrosing Alveolitis

1999 • 388 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Angiotensin II Blockade Reverses Myocardial Fibrosis in a Transgenic Mouse Model of Human Hypertrophic Cardiomyopathy

2001 • 377 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

1995 • 364 citations

Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder

2001 • 356 citations

Idiopathic Interstitial Pneumonias: Diagnostic Accuracy of Thin-Section CT in 129 Patients

1999 • 355 citations

Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

1999 • 354 citations

Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.

1994 • 353 citations

Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression

2001 • 348 citations

Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.

1996 • 343 citations

Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy

2001 • 341 citations

Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP

1998 • 336 citations

Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure.

1993 • 329 citations

Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts.

1990 • 320 citations

<scp>D</scp>-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma)

1982 • 317 citations

Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

1993 • 313 citations

Cryptogenic Organizing Pneumonia

2000 • 306 citations

Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

1995 • 306 citations

Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?

1999 • 300 citations

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma.

1999 • 297 citations

Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic fibrosing alveolitis.

1989 • 296 citations

Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung

1998 • 291 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis

1993 • 284 citations

Antioxidative and Clinical Effects of High-doseN-Acetylcysteine in Fibrosing Alveolitis

1997 • 280 citations

Mycophenolate mofetil

1996 • 273 citations

Recombinant Human Relaxin in the Treatment of Scleroderma

2000 • 267 citations

Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure.

1994 • 266 citations

Idiopathic Pulmonary Fibrosis

2000 • 265 citations

Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.

1998 • 259 citations

Cryptogenic fibrosing alveolitis: response to corticosteroid treatment and its effect on survival

1980 • 253 citations

Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy.

1987 • 253 citations

Cryptogenic fibrosing alveolitis. Relationships of pulmonary physiology and bronchoalveolar lavage to response to treatment and prognosis.

1981 • 253 citations

Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases.

1998 • 242 citations

Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1

2001 • 241 citations

Increased Endothelin-1 in Bleomycin-induced Pulmonary Fibrosis and the Effect of an Endothelin Receptor Antagonist

1997 • 241 citations

Pulmonary Function in Idiopathic Pulmonary Fibrosis and Referral for Lung Transplantation

2001 • 235 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

1996 • 234 citations

Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease

1999 • 231 citations

Adult familial cryptogenic fibrosing alveolitis in the United Kingdom

2000 • 229 citations

Heterogeneous Proliferative Characteristics of Human Adult Lung Fibroblast Lines and Clonally Derived Fibroblasts from Control and Fibrotic Tissue

1988 • 228 citations

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

2000 • 222 citations

Targeting TGF-β overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade

1998 • 222 citations

Acute interstitial pneumonia

2000 • 213 citations

Angiotensin II blockade decreases TGF-β1 and matrix proteins in cyclosporine nephropathy

1997 • 207 citations

Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor

2000 • 206 citations

Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality.

1996 • 206 citations

Simultaneous or Delayed Administration of Hepatocyte Growth Factor Equally Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin

1997 • 204 citations

3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation

2002 • 203 citations

Effect of pirfenidone on the pulmonary fibrosis of Hermansky–Pudlak syndrome

2002 • 201 citations

The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis

1994 • 197 citations

Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice

2002 • 193 citations

Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF

2001 • 192 citations

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

1993 • 188 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo

2001 • 187 citations

Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lung.

1997 • 187 citations

Increased Risk of Fibrosing Alveolitis Associated with Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor- α Gene Polymorphisms

2000 • 186 citations

Colchicine versus Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis

1998 • 185 citations

Future Research Directions in Idiopathic Pulmonary Fibrosis

2002 • 183 citations

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

1996 • 182 citations

Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival∗∗Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/

2001 • 180 citations

Survival in Patients With Cryptogenic Fibrosing Alveolitis

1998 • 179 citations

Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury

1997 • 178 citations

Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis

1997 • 178 citations

Keratinocyte growth factor reduces lung damage due to acid instillation in rats.

1996 • 178 citations

Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

1999 • 177 citations

Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis.

1996 • 175 citations

Diffuse interstitial pneumonitis

1978 • 174 citations

Asbestos Fibers and Silica Particles Stimulate Rat Alveolar Macrophages To Release Tumor Necrosis Factor: Autoregulatory Role of Leukotriene B₄

1989 • 173 citations

Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines.

1997 • 171 citations

Proteoglycan deposition in pulmonary fibrosis.

1996 • 169 citations

Fibroblasts as Sentinel Cells

2001 • 168 citations

The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogenic fibrosing alveolitis.

1987 • 167 citations

Prostaglandin E₂inhibits fibroblast chemotaxis

2001 • 164 citations

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: Implications for antifibrotic therapy

2002 • 163 citations

Transforming growth factor-β1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction

2000 • 160 citations

Prognosis of cryptogenic fibrosing alveolitis.

1983 • 158 citations

Reactive pulmonary lymphoid disorders

1995 • 155 citations

Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders.

1997 • 154 citations

NF-kappaB Inhibits Expression of the alpha1(I) Collagen Gene

1999 • 152 citations

Losartan decreases plasma levels of TGF-β1 in transplant patients with chronic allograft nephropathy

1999 • 152 citations

Determinants of progression in idiopathic pulmonary fibrosis.

1994 • 152 citations

Tissue Factor Expression and Fibrin Deposition in the Lungs of Patients with Idiopathic Pulmonary Fibrosis and Systemic Sclerosis

1997 • 151 citations

Differential Proliferation of Fibroblasts Cultured from Normal and Fibrotic Human Lungs

1988 • 149 citations

Corticosteroids and the Treatment of Idiopathic Pulmonary Fibrosis

1996 • 146 citations

Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.

1995 • 146 citations

Interferon-γ inhibits experimental renal fibrosis

1999 • 144 citations

Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis

2000 • 144 citations

Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro

1995 • 143 citations

Cryptogenic fibrosing alveolitis with preserved lung volumes

1997 • 137 citations

Pulmonary fibrosis deaths in the United States, 1979-1991. An analysis of multiple-cause mortality data.

1996 • 136 citations

Acute Interstitial Pneumonitis: Case Series and Review of the Literature

2000 • 134 citations

Chemokines and CD40 expression in human fibroblasts

2000 • 134 citations

Colchicine, D-Penicillamine, and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis

1998 • 133 citations

Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro.

1994 • 133 citations

BIOSYNTHESIS AND MATURATION OF SKIN COLLAGEN IN SCLERODERMA, AND EFFECT OF D-PENICILLAMINE

1974 • 130 citations

Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts

2001 • 130 citations

Open-label Compassionate Use One Year-treatment with Pirfenidone to Patients with Chronic Pulmonary Fibrosis.

2002 • 129 citations

Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides

1999 • 128 citations

Treatment of chronic myelogenous leukemia with the tyrosine kinase inhibitor STI571 results in marked regression of bone marrow fibrosis

2002 • 128 citations

Pharmacological Therapy for Idiopathic Pulmonary Fibrosis

1999 • 127 citations

Rho‐dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)

2001 • 126 citations

CA repeat allele polymorphism in the first intron of the human interferon-γ gene is associated with lung allograft fibrosis

1999 • 124 citations

Attenuation of Lung Inflammation and Fibrosis in Interferon- γ –Deficient Mice after Intratracheal Bleomycin

2001 • 124 citations

The Diagnosis, Assessment and Treatment of Diffuse Parenchymal Lung Disease in Adults

1999 • 124 citations

Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1

2002 • 123 citations

Human Relaxin Decreases Collagen Accumulation In Vivo in Two Rodent Models of Fibrosis

1993 • 122 citations

The Role of Hepatic Stellate Cells and Transforming Growth Factor-β1 in Cystic Fibrosis Liver Disease

2002 • 121 citations

Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis.

1995 • 120 citations

Peribiliary myofibroblasts in biliary type liver fibrosis

2002 • 116 citations

Blocking Sp1 Transcription Factor Broadly Inhibits Extracellular Matrix Gene Expression In Vitro and In Vivo: Implications for the Treatment of Tissue Fibrosis

2001 • 115 citations

Focal Segmental Glomerulosclerosis

1999 • 113 citations

Pulmonary Function Tests and CT Scan in the Management of Idiopathic Pulmonary Fibrosis

1998 • 112 citations

The Differential Effect of Prostaglandin E2 on Transforming Growth Factor-β and Insulin-induced Collagen Formation in Lung Fibroblasts

1989 • 110 citations

Mortality rates from cryptogenic fibrosing alveolitis in seven countries.

1996 • 110 citations

Deactivation of cultured human liver myofibroblasts by Trans -resveratrol, a grapevine-derived polyphenol

2000 • 108 citations

Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor.

1997 • 107 citations

uPA/Plasmin System-Mediated MMP-9 Activation Is Implicated in Bronchial Epithelial Cell Migration

2001 • 107 citations

Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney

2002 • 105 citations

Treatment of Bleomycin-Induced Pulmonary Fibrosis by Transfer of Urokinase-Type Plasminogen Activator Genes

1999 • 102 citations

Effect of γ-Interferon on Collagen Synthesis by Normal and Fibrotic Human Lung Fibroblasts

1992 • 102 citations

Lovastatin Induces Fibroblast ApoptosisIn Vitro and In Vivo

1999 • 101 citations

Transforming Growth Factor-β1-induced Activation of the ERK Pathway/Activator Protein-1 in Human Lung Fibroblasts Requires the Autocrine Induction of Basic Fibroblast Growth Factor

2000 • 101 citations

Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms

2002 • 101 citations

Use of Intermittent, Intravenous Cyclophosphamide for Idiopathic Pulmonary Fibrosis

1992 • 98 citations

The effect of D‐penicillamine on pulmonary findings in systemic sclerosis

1985 • 97 citations

Infliximab

2002 • 96 citations

Cyclophosphamide in the Treatment of Idiopathic Pulmonary Fibrosis

2000 • 95 citations

Enhanced migration of fibroblasts derived from lungs with fibrotic lesions.

1995 • 95 citations

Molecular mechanisms of pulmonary fibrosis

2002 • 94 citations

Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice

2001 • 92 citations

Oxidants/antioxidants in idiopathic pulmonary fibrosis.

1995 • 90 citations

Radiation pneumotoxicity in rats: Modification by inhibitors of angiotensin converting enzyme

1992 • 89 citations

PDE4 Inhibitors Attenuate Fibroblast Chemotaxis and Contraction of Native Collagen Gels

2002 • 89 citations

Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis A quantitative study of open lung biopsies

1999 • 87 citations

Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis.

1998 • 87 citations

Effect of endothelin-1 on α-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases

1999 • 87 citations

D‐penicillamine therapy and interstitial lung disease in scleroderma. a long‐term followup study

1987 • 85 citations

Colchicine Suppresses the Release of Fibroblast Growth Factors from Alveolar MacrophagesIn Vitro: The Basis of a Possible Therapeutic Approach to the Fibrotic Disorders

1988 • 84 citations

Colchicine in the Treatment of Pulmonary Fibrosis

1993 • 82 citations

Inhibition of tumor necrosis factor and subsequent endotoxin shock by pirfenidone

1998 • 80 citations

Antiinflammatory and Antifibrotic Properties of Colchicine: Implications for Idiopathic Pulmonary Fibrosis

1997 • 79 citations

Expression of tumour necrosis factor‐α in cryptogenic fibrosing alveolitis

1993 • 76 citations

The management of cryptogenic fibrosing alveolitis in three regions of the United Kingdom

1993 • 75 citations

Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis

1995 • 75 citations

Myofibroblasts: Molecular crossdressers

2001 • 74 citations

Effects of AT1 receptor antagonist, losartan, on rat hepatic fibrosis induced by CCl(4).

2000 • 74 citations

A 15-year prospective study of treatment of rapidly progressive systemic sclerosis with D-penicillamine [see comment].

1991 • 73 citations

Cyclosporin as a treatment for interstitial lung disease of unknown aetiology.

1991 • 73 citations

Pharmacologic Suppression of the Neutrophil Component of the Alveolitis in Idiopathic Pulmonary Fibrosis

1987 • 73 citations

Interferon-γ Coordinately Upregulates Matrix Metalloprotease (MMP)-1 and MMP-3, But Not Tissue Inhibitor of Metalloproteases (TIMP), Expression in Cultured Keratinocytes

1995 • 73 citations

Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeleton

2001 • 72 citations

Pirfenidone induces intercellular adhesion molecule-1 (ICAM-1) down-regulation on cultured human synovial fibroblasts

1998 • 72 citations

Apoptotic Activity is Increased in the Newly Formed Fibromyxoid Connective Tissue in Bronchiolitis Obliterans Organizing Pneumonia

1999 • 72 citations

Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue.

1994 • 68 citations

Pulmonary 99mTc-DTPA aerosol clearance and survival in usual interstitial pneumonia (UIP)

2001 • 68 citations

Relaxin Alone and in Conjunction with Interferon-γ Decreases Collagen Synthesis by Cultured Human Scleroderma Fibroblasts

1992 • 68 citations

Phenotypic Characteristics and Cyclin-Dependent Kinase Inhibitors Repression in Hyperplastic Epithelial Pathology in Idiopathic Focal Segmental Glomerulosclerosis

2000 • 66 citations

Neutrophil Chemotactic Factors in the Respiratory Tract of Patients with Chronic Airway Diseases or Idiopathic Pulmonary Fibrosis

1992 • 65 citations

Colchicine Versus Prednisone as Treatment of Usual Interstitial Pneumonia

1997 • 64 citations

Alveolar Macrophages from Patients with Asbestos Exposure Release Increased Levels of Leukotriene B₄

1989 • 63 citations

Relevance of Tissue Factor and Tissue Factor Pathway Inhibitor for Hypercoagulable State in the Lungs of Patients with Idiopathic Pulmonary Fibrosis

2000 • 63 citations

Captopril Inhibits Proliferation of Human Lung Fibroblasts in Culture: A Potential Antifibrotic Mechanism

1994 • 62 citations

RETRACTED: Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy

1998 • 62 citations

Hospital-based historical cohort study of 234 histologically proven Japanese patients with IPF.

1999 • 62 citations

Outcome of Subjects With Idiopathic Pulmonary Fibrosis Who Fail Corticosteroid Therapy

1993 • 61 citations

Upregulated Expression of Fibroblast Growth Factor (FGF) Receptors by Transforming Growth Factor-β1 (TGF-β1) Mediates Enhanced Mitogenic Responses to FGFs in Cultured Human Lung Fibroblasts

1998 • 60 citations

The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced by thioacetamide

2000 • 58 citations

Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation

1997 • 58 citations

Effect of Endothelin Receptor Antagonists (BQ-485, Ro 47-0203) on Collagen Deposition During the Development of Bleomycin-Induced Pulmonary Fibrosis in Rats

1998 • 57 citations

Normal scarring: importance of myofibroblasts

2002 • 57 citations

Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor-beta1 inhibits fibrogenic activities of hepatic stellate cells.

2002 • 57 citations

Endothelin A Receptor Blockade Decreases Expression of Growth Factors and Collagen and Improves Matrix Metalloproteinase-2 Activity in Kidneys from Stroke-Prone Spontaneously Hypertensive Rats

2002 • 57 citations

Usual Interstitial Pneumonia

2001 • 56 citations

ALTERATIONS IN CYTOKERATIN EXPRESSION BY THE ALVEOLAR LINING EPITHELIAL CELLS IN LUNG TISSUES FROM PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS

1997 • 54 citations

Soluble Transforming Growth Factor- β Type III Receptor Gene Transfection Inhibits Fibrous Airway Obliteration in a Rat Model of Bronchiolitis Obliterans

2002 • 52 citations

Interferon‐γ inhibits the myofibroblastic phenotype of rat palatal fibroblasts induced by transforming growth factor‐β1 in vitro

1999 • 52 citations

Cyclophosphamide pulse therapy in idiopathic pulmonary fibrosis

1998 • 50 citations

Clinical usefulness of high resolution computed tomography in cryptogenic fibrosing alveolitis

1998 • 48 citations

Neutralization of transforming growth factor-beta 1 in a mouse model of immune-induced lung fibrosis.

1994 • 47 citations

Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A

1989 • 47 citations

Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.

1993 • 46 citations

Skin collagen in patients with scleroderma: biosynthesis and maturation in vitro, and the effect of D-penicillamine.

1970 • 45 citations

Determinants of response to immunosuppressive therapy in idiopathic pulmonary fibrosis

1994 • 45 citations

Transforming growth factor- induces collagen synthesis without inducing IL-8 production in mesothelial cells

2003 • 44 citations

Corticosteroids in idiopathic pulmonary fibrosis

2001 • 44 citations

Clinical Evaluation of the Management of Community-Acquired Pneumonia by General Practitioners in France

2001 • 44 citations

Tenascin mRNA Expression at the Foci of Recent Injury in Usual Interstitial Pneumonia

2000 • 39 citations

Fibroblast Contractility

2000 • 38 citations

Idiopathic Pulmonary Fibrosis: Current Clinical Concepts and Challenges in Management

1994 • 38 citations

Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females.

1998 • 38 citations

Endothelin-1 Secretion by Alveolar Macrophages in Systemic Sclerosis

1997 • 37 citations

Bone marrow stem cells do not repopulate the healthy upper respiratory tract

2002 • 35 citations

Nonspecific Interstitial Pneumonia (NSIP)

2001 • 35 citations

The role of pulmonary function testing in pulmonary fibrosis

2000 • 34 citations

LU135252, an endothelin_A receptor antagonist did not prevent pulmonary vascular remodelling or lung fibrosis in a rat model of myocardial infarction

2000 • 29 citations

D-Penicillamine Prevents Collagen Accumulation in Lungs of Rats Given Bleomycin

1986 • 29 citations

Efficacy of cyclosporine to reduce steroids in patients with idiopathic pulmonary fibrosis before lung transplantation.

1993 • 29 citations

Interferon- γ Upregulates the c-Met/Hepatocyte Growth Factor Receptor Expression in Alveolar Epithelial Cells

1999 • 27 citations

Lung statics and connective tissues after penicillamine in bleomycin-treated hamsters

1980 • 27 citations

The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation

1978 • 27 citations

Mechanism of Structural Remodeling in Pulmonary Fibrosis

2001 • 23 citations

Regulation of Alveolar Macrophage Production of Chemoattractants by Leukotrine B₄ and Prostaglandin E₂

1991 • 23 citations

Efficacy of cyclosporin A for idiopathic pulmonary fibrosis

1990 • 20 citations

Effects of interferons on proliferation and collagen synthesis of rat palatal wound fibroblasts

1999 • 20 citations

Idiopathic Pulmonary Fibrosis and Cyclosporine

1998 • 16 citations

Role of clot‐associated (‐derived) thrombin in cell proliferation induced by fibrin clots in vitro

2000 • 15 citations

THE MANAGEMENT OF PNEUMONIA.

1964 • 12 citations

Adverse effects of cyclophosphamide in idiopathic pulmonary fibrosis.

1985 • 12 citations

H2O2 Production by Myofibroblasts Is Dependent on Src Kinase(s) and Actin Cytoskeletal Regulation

2001 • 5 citations

Future Directions in the Treatment of Idiopathic Pulmonary Fibrosis

2003 • 2 citations