Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1961 • 3,860 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

1990 • 555 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.

1988 • 418 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Transforming growth factors and the regulation of cell proliferation

1990 • 390 citations

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

1988 • 340 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Cytokine Networks in the Regulation of Inflammation and Fibrosis in the Lung

1990 • 266 citations

Collagen polymorphism in idiopathic chronic pulmonary fibrosis.

1976 • 264 citations

Bleomycin, a review.

1976 • 210 citations

Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.

1988 • 199 citations

Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.

1987 • 188 citations

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

1987 • 181 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Collagen Synthesis by Normal and Fibrotic Human Lung Fibroblasts and the Effect of Transforming Growth Factor-β

1989 • 155 citations

Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters.

1983 • 144 citations

Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis.

1989 • 134 citations

Profiles of steady state levels of messenger RNAs coding for type I procollagen, elastin, and fibronectin in hamster lungs undergoing bleomycin-induced interstitial pulmonary fibrosis.

1985 • 131 citations

Interferons and Collagen Production

1990 • 109 citations

Protein Metabolism during Bleomycin-induced Pulmonary Fibrosis in Rabbits

1983 • 100 citations

Recombinant gamma, alpha, and beta interferon regulation of human lung fibroblast proliferation.

1987 • 90 citations

Effect of Murine Gamma Interferon on the Cellular Responses to Bleomycin in Mice

1988 • 90 citations

Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice

1986 • 88 citations

SpontaneousIn VitroRelease of Alveolar-Macrophage Cytokines after the Intratracheal Instillation of Bleomycin in Rats: Characterization and Kinetic Studies

1988 • 86 citations

Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated wth decreaded levels of the procollagen mRNAs(FEBS 2156)

1985 • 83 citations

Synergistic effect of tumor necrosis factor-α and interferon-γ on collagen synthesis of human skin fibroblasts in vitro

1989 • 77 citations

Bleomycin selectively elevates mRNA levels for procollagen and fibronectin following acute lung injury

1985 • 52 citations

Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.

1993 • 46 citations

Pulmonary toxicity of bleomycin analogs

1980 • 44 citations

Bleomycin-stimulated hamster alveolar macrophages release interleukin-1.

1988 • 43 citations

Molecular mechanisms of collagen gene expression

1989 • 42 citations