Transforming Growth Factor-β- and Tumor Necrosis Factor-α-mediated Induction and Proteolytic Activation of MMP-9 in Human Skin

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Activated macrophages induce vascular proliferation

1977 • 818 citations

Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9

1993 • 728 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Cytokine regulation of metalloproteinase gene expression

1993 • 432 citations

Expression of matrix metalloproteinase-2 and -9 during early human wound healing.

1994 • 411 citations

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

2001 • 395 citations

Matrix metalloproteinases in repair

1999 • 375 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.

1991 • 343 citations

Dual role of tumor necrosis factor-alpha in angiogenesis.

1992 • 342 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

Reporter constructs with low background activity utilizing the cat gene

1992 • 240 citations

Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase

1989 • 233 citations

Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2

1997 • 217 citations

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes.

1993 • 211 citations

Transforming growth factor-β: possible roles in carcinogenesis

1988 • 196 citations

Steps Involved in Activation of the Pro-matrix Metalloproteinase 9 (Progelatinase B)-Tissue Inhibitor of Metalloproteinases-1 Complex by 4-Aminophenylmercuric Acetate and Proteinases

1995 • 189 citations

Novel Regulation of Type IV Collagenase (Matrix Metalloproteinase-9 and -2) Activities by Transforming Growth Factor-β1 in Human Prostate Cancer Cell Lines

1999 • 163 citations

Increased Types I and III Collagen and Transforming Growth Factor-β1 mRNA and Protein in Hypertrophic Burn Scar

1995 • 152 citations

Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin

1989 • 151 citations

Enhanced expression of mRNA for transforming growth factor-beta, type I and type III procollagen in human post-burn hypertrophic scar tissues.

1993 • 150 citations

Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing

1996 • 127 citations

Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.

1993 • 126 citations

Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor and gelatinase‐B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing

1999 • 125 citations

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

1990 • 124 citations

Expression of matrix metalloproteinases (MMP‐2 and ‐9) and tissue inhibitors of metalloproteinases (TIMP‐1 and ‐2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells

1999 • 105 citations

Metalloproteinase Activation Cascade After Burn Injury: A Longitudinal Analysis of the Human Wound Environment

1994 • 104 citations

Interleukin‐8 levels and activity in delayed‐healing human thermal wounds

2000 • 103 citations

Cytokines : a practical approach

1995 • 101 citations

A major advance in the use of growth factors to enhance wound healing.

1993 • 95 citations

Identification of a Transforming Growth Factor-β1/Bone Morphogenetic Protein 4 (TGF-β1/BMP4) Response Element within the Mouse Tissue Transglutaminase Gene Promoter

1998 • 91 citations

Gelatinase activity in keloids and hypertrophic scars

1999 • 91 citations

Prognostic value of markers of collagen remodeling in venous ulcers

1999 • 91 citations

Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9

1997 • 87 citations

Transforming growth factor beta1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro.

1996 • 83 citations

Phenotypic Differences in Cytokine Responsiveness of Hypertrophic Scar Versus Normal Dermal Fibroblasts

1993 • 72 citations

Cooperation between SMAD and NF-κB in growth factor regulated type VII collagen gene expression

1999 • 66 citations

Recombinant Human Transforming Growth Factor—Beta 1 (rhTGF-β1) Enhances Healing and Strength of Granulation Skin Wounds

1990 • 58 citations

Stromelysin-1 (MMP-3)–Independent Gelatinase Expression and Activation in Mice

1998 • 54 citations

Tumor Necrosis Factor Mediates Impaired Wound Healing in Chronic Abdominal Sepsis

1997 • 53 citations

TGF‐β and Wound Healing

2007 • 50 citations

Sequential production and activation of matrix-metalloproteinase-9 (MMP-9) with breast cancer progression

1997 • 43 citations

Cytokines: A Practical Approach.

1994 • 43 citations

Unique activation of matrix metalloproteinase-9 within human liver metastasis from colorectal cancer

1998 • 41 citations

Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

2000 • 41 citations

Tumour necrosis factor: roles in cancer pathophysiology.

1992 • 26 citations

Marked induction of gelatinases, especially type B, in host fibroblasts by human ovarian cancer cells in athymic mice

1995 • 21 citations

Transient Exposure to Tumor Necrosis Factor-α Inhibits Collagen Accumulation by Cultured Hypertrophic Scar Fibroblasts

1999 • 20 citations

Altered biosynthesis of tumour necrosis factor (TNF) alpha is involved in postburn hypertrophic scars

1994 • 20 citations

Matrix Metalloproteases

2017 • 7 citations