p38 MAP kinase: a convergence point in cancer therapy

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

2003 • 1,164 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

2002 • 551 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

1999 • 348 citations

Primary Structure of BMK1: A New Mammalian MAP Kinase

1995 • 345 citations

The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

2000 • 333 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53.

2002 • 233 citations

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells

2000 • 230 citations

Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor

2004 • 228 citations

p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells.

2003 • 191 citations

BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect

2003 • 185 citations

p38 MAP Kinase—a molecular switch between VEGF‐induced angiogenesis and vascular hyperpermeability

2002 • 175 citations

p38 Mitogen-Activated Protein Kinase Mediates Cell Death and p21-Activated Kinase Mediates Cell Survival during Chemotherapeutic Drug-induced Mitotic Arrest

2003 • 159 citations

Role of the p38 MAPK pathway in cisplatin-based therapy

2003 • 159 citations

Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth

1999 • 152 citations

Involvement of the p38 mitogen‐activated protein kinase cascade in hepatocellular carcinoma

2003 • 150 citations

Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors

1993 • 146 citations

ERK inhibitor PD98059 enhances docetaxel‐induced apoptosis of androgen‐independent human prostate cancer cells

2003 • 138 citations

Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis

2003 • 136 citations

ERK8, a New Member of the Mitogen-activated Protein Kinase Family

2002 • 125 citations

Suppression of Extracellular Signal-related Kinase and Activation of p38 MAPK Are Two Critical Events Leading to Caspase-8- and Mitochondria-mediated Cell Death in Phytosphingosine-treated Human Cancer Cells

2003 • 122 citations

Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway.

2001 • 116 citations

Regulation of p73 by c-Abl through the p38 MAP kinase pathway

2002 • 109 citations

p38 Mitogen-Activated Protein Kinases on the Body Surface – A Function for p38δ

2003 • 90 citations

p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival

2003 • 77 citations

Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway

2003 • 75 citations

Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2

2003 • 68 citations

Okadaic Acid and Anisomycin are Protective and Stimulate the SAPK/JNK Pathway

1999 • 60 citations

Down-regulation of the Phosphatidylinositol 3-Kinase/Akt Pathway Is Involved in Retinoic Acid-induced Phosphorylation, Degradation, and Transcriptional Activity of Retinoic Acid Receptor γ2

2002 • 52 citations

p38 Mitogen-Activated Protein Kinase Regulates Bax Translocation in Cyanide-Induced Apoptosis

2003 • 51 citations

Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain

2003 • 49 citations

Overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukaemia

2003 • 30 citations