Pirfenidone effectively reverses experimental liver fibrosis

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

Treatment of Idiopathic Pulmonary Fibrosis with a New Antifibrotic Agent, Pirfenidone

1999 • 465 citations

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

2000 • 402 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

An improved method for determining specific radioactivities of proline-14C and hydroxyproline-14C in collagen and in noncollagenous proteins

1974 • 244 citations

Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters.

1995 • 213 citations

Pirfenidone improves renal function and fibrosis in the post-obstructed kidney

1998 • 156 citations

Mechanisms and therapy of hepatic fibrosis: Report of the AASLD single topic basic research conference

2000 • 140 citations

Liver Cirrhosis Is Reverted by Urokinase-Type Plasminogen Activator Gene Therapy

2000 • 119 citations

Carbon tetrachloride hepatotoxicity:status quo and future prospects

1983 • 113 citations

Pirfenidone: A Novel Pharmacological Agent That Inhibits Leiomyoma Cell Proliferation and Collagen Production

1998 • 92 citations

Pirfenidone in the treatment of primary sclerosing cholangitis.

2002 • 58 citations

Cholestasis-induced fibrosis is reduced by interferon α-2a and is associated with elevated liver metalloprotease activity

2000 • 35 citations

Kupffer cells from carbon tetrachloride-injured rat livers produce chemotactic factors for fibroblasts and monocytes: The role of tumor necrosis factor-α

1991 • 35 citations

Pirfenidone: A Novel Pharmacological Agent That Inhibits Leiomyoma Cell Proliferation and Collagen Production

1998 • 29 citations

Treatment with anti-tumor growth factor β antibodies influences an altered pattern of cytokines gene expression in injured rat liver

1998 • 28 citations

Involution of keloid implants in athymic mice treated with pirfenidone or with triamcinolone

1998 • 27 citations

Intramuscular Injection of an Adenoviral Vector Expressing Hepatocyte Growth Factor Facilitates Hepatic Transduction with a Retroviral Vector in Mice

1999 • 26 citations

Pirfenidone: a novel antifibrotic agent with implications for the treatment of obliterative bronchiolitis

1998 • 23 citations

Antisense S-oligodeoxynucleotides down-regulate TGFβ-production by Kupffer cells from CCl4-injured rat livers

1997 • 19 citations

Effects of pirfenidone and dermoid cyst fluid on adhesion formation

1998 • 17 citations