Fibre differentiation and polarity in the mammalian lens: a key role for FGF

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice

1960 • 811 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2

1994 • 539 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

Neutralising antibody to TGF-β1,2 reduces cutaneous scarring in adult rodents

1994 • 499 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye.

1989 • 481 citations

Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.

1991 • 470 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

Developmental changes in heparan sulfate expression: in situ detection with mAbs.

1992 • 464 citations

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

1992 • 461 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

Growth factors are released by mechanically wounded endothelial cells.

1989 • 420 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

The fibroblast growth factor family: Structural and biological properties

1989 • 362 citations

Controlled and modulated release of basic fibroblast growth factor

1991 • 361 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues

1986 • 340 citations

Transforming growth factor-β in human aqueous humor

1990 • 337 citations

Cell Production and Migration in the Epithelial Layer of the Cornea

1960 • 327 citations

Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration

1989 • 324 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

The maturation of the lens cell: a morphologic study

1975 • 287 citations

Purification of heparin-binding growth factors

1986 • 279 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Retina- and eye-derived endothelial cell growth factors: partial molecular characterization and identity with acidic and basic fibroblast growth factors

1985 • 268 citations

Expression of FGF receptor gene in rat development

1991 • 264 citations

Insulin-Like Growth Factors in Vitreous: Studies in Control and Diabetic Subjects with Neovascularization

1986 • 255 citations

Ocular Anatomy Embryology and Teratology

1983 • 255 citations

Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor.

1994 • 254 citations

Lens Development: Fiber Elongation and Lens Orientation

1963 • 243 citations

Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor.

1990 • 243 citations

Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.

1992 • 241 citations

Mechanisms of Cataract Formation in the Human Lens

1981 • 239 citations

Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperativity

1992 • 236 citations

Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation.

1990 • 234 citations

Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities.

1984 • 224 citations

Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice

1995 • 222 citations

Basic Fibroblast Growth Factor Levels in the Vitreous of Patients With Proliferative Diabetic Retinopathy

1990 • 217 citations

Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins.

1991 • 216 citations

Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors

1993 • 215 citations

Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

1990 • 212 citations

Ocular anatomy, embryology, and teratology

1982 • 204 citations

Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.

1990 • 203 citations

Fibroblast growth factors and their receptors: An information network controlling tissue growth, morphogenesis and repair

1994 • 195 citations

Cataract induction in lenses cultured with transforming growth factor-beta.

1995 • 190 citations

Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye.

1993 • 188 citations

Cell division, cell elongation and distribution of α-, β- and γ-crystallins in the rat lens

1978 • 185 citations

Expression of a truncated FGF receptor results in defective lens development in transgenic mice

1995 • 176 citations

Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta.

1994 • 172 citations

TGF-β1 induces lens cells to accumulate α-smooth muscle actin, a marker for subcapsular cataracts

1994 • 171 citations

Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns

1993 • 169 citations

Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors.

1987 • 165 citations

Induction of Lens Fibre Differentiation by Acidic and Basic Fibroblast Growth Factor (FGF)

1989 • 155 citations

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens

1995 • 154 citations

The Control of Cell Division in the Ocular Lens

1971 • 147 citations

Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol-anchored heparan sulfate proteoglycan.

1991 • 145 citations

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?

1991 • 140 citations

Bovine retina contains three growth factor activities with different affinity to heparin: eye derived growth factor I, II, III

1985 • 139 citations

Expression of TGF-β isoforms during first trimester human embryogenesis

1990 • 139 citations

Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat

1978 • 133 citations

Denucleation process of the lens.

1974 • 133 citations

Macromolecular organization of basement membranes. Characterization and comparison of glomerular basement membrane and lens capsule components by immunochemical and lectin affinity procedures.

1986 • 130 citations

Extracellular matrix regulation of growth factor and protease activity

1991 • 128 citations

Mechanisms of cataract formation in the human lens

1981 • 127 citations

Evidence that fibroblast growth factor promotes lens fibre differentiation

1987 • 127 citations

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

1993 • 123 citations

Growth factors in the eye

1990 • 122 citations

The Role of Fibroblast Growth Factor in Eye Lens Development^a

1991 • 118 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

Acidic fibroblast growth factor in the developing rat embryo.

1991 • 115 citations

Induction of the Eye Lens

1980 • 111 citations

Immunological study of acidic fibroblast growth factor (aFGF) distribution in the eye

1989 • 109 citations

Inhibitory effect of TGF-beta 2 in human aqueous humor on bovine lens epithelial cell proliferation.

1994 • 106 citations

The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice.

1994 • 104 citations

Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes

1990 • 99 citations

Identification of soluble forms of the fibroblast growth factor receptor in blood.

1994 • 97 citations

Lens development

1965 • 96 citations

Distribution of IGF-I and -II, IGF Binding Proteins (IGFBPs) and IGFBP mRNA in Ocular Fluids and Tissues: Potential Sites of Synthesis of IGFBPs in Aqueous and Vitreous

1993 • 94 citations

Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina

1989 • 88 citations

Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens: implications for lens polarity and growth patterns.

1993 • 87 citations

Cell Production and Migration in the Epithelial Layer of the Lens

1961 • 87 citations

Localisation of laminin and fibronectin during rat lens morphogenesis

1984 • 86 citations

Molecular and Cellular Aspects of Insulin-like Growth Factor Action

1994 • 84 citations

GROWTH OF LENS AND OCULAR ENVIRONMENT: ROLE OF NEURAL RETINA IN THE GROWTH OF MOUSE LENS AS REVEALED BY AN IMPLANTATION EXPERIMENT

1976 • 84 citations

Internalization and processing of basic fibroblast growth factor by neurons and astrocytes

1991 • 83 citations

Insulin initiation of lens fiber differentiation in culture: Elongation of embryonic lens epithelial cells

1973 • 80 citations

Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF)

1989 • 80 citations

Insulin growth factor and epidermal growth factor trigger mitosis in lenses cultured in a serum-free medium.

1983 • 80 citations

Insulin-like growth factors in vitreous. Studies in control and diabetic subjects with neovascularization

1986 • 78 citations

Interaction of transforming growth factor-beta 1 with alpha 2-macroglobulin. Role in transforming growth factor-beta 1 clearance.

1991 • 76 citations

The roles of laminin and fibronectin in the development of the lens capsule

1991 • 76 citations

Receptors for insulin and epidermal growth factor: Relation to synthesis of DNA in cultured rabbit lens epithelium

1975 • 75 citations

Distribution of Acidic and Basic Fibroblast Growth Factors (FGF) in the Foetal Rat Eye: Implications for Lens Development

1992 • 74 citations

Isolation of an amino terminal extended form of basic fibroblast growth factor

1986 • 74 citations

Rise and fall of crystallin gene messenger levels during fibroblast growth factor induced terminal differentiation of lens cells

1992 • 73 citations

Neural retinas promote cell division and fibre differentiation in lens epithelial explants

1984 • 73 citations

Regulation of lens cell growth and polarity by an embryo-specific growth factor and by inhibitors of lens cell proliferation and differentiation

1993 • 72 citations

Immunohistochemical localization of basic fibroblast growth factor in mature and developing retinas of normal and RCS rats

1992 • 70 citations

Low mature TGF-beta 2 levels in aqueous humor during uveitis.

1994 • 70 citations

Onset of fibre differentiation in cultured rat lens epithelium under the influence of neural retina-conditioned medium

1984 • 68 citations

Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants.

1995 • 67 citations

IGF Enhancement of FGF-induced Fibre Differentiation and DNA Synthesis in Lens Explants

1996 • 65 citations

Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth

1997 • 65 citations

Detection, quantification, and significance of basic fibroblast growth factor in the aqueous humor of man, cat, dog and pig

1992 • 65 citations

Developmental expression of crystallin genes: In situ hybridization reveals a differential localization of specific mRNAs

1987 • 64 citations

Cell Biology of the Eye

1982 • 61 citations

Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.

1989 • 59 citations

Expression of the gene for main intrinsic polypeptide (MIP): separate spatial distributions of MIP and beta-crystallin gene transcripts in rat lens development.

1988 • 59 citations

Inhibition of transforming growth factor-beta-induced cataractous changes in lens explants by ocular media and alpha 2-macroglobulin.

1996 • 57 citations

FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth

1996 • 54 citations

Up‐regulation of aFGF expression in quiescent cells is related to cell survival

1994 • 52 citations

Age of rats affects response of lens epithelial explants to fibroblast growth factor

1992 • 52 citations

Insulin-like Growth Factor I and Insulin Regulate δ-Crystallin Gene Expression in Developing Lens

1989 • 51 citations

Sequential structural response of lens epithelium to retina-conditioned medium

1984 • 51 citations

Release of cell surface‐associated basic fibroblast growth factor by glycosylphosphatidylinositol‐specific phospholipase C

1992 • 50 citations

The Effects of Insulin and Basic Fibroblast Growth Factor on Fibre Differentiation in Rat Lens Epithelial Explants

1991 • 49 citations

β- and γ-Crystallin Synthesis in Rat Lens Epithelium Explanted with Neural Retina

1980 • 48 citations

Expression of multiple species of basic fibroblast growth factor mRNA and protein in normal and tumor-derived mammary epithelial cells in culture.

1991 • 48 citations

Chicken lens development: Epithelial cell production and migration

1966 • 47 citations

Characterization of heparan sulfate proteoglycan from calf lens capsule and proteoglycans synthesized by cultured lens epithelial cells. Comparison with other basement membrane proteoglycans

1991 • 45 citations

Growth factors in the aqueous humor and their therapeutic implications in glaucoma and anterior segment disorders of the human eye

1991 • 45 citations

Age-related changes in fibre differentiation of rat lens epithelial explants exposed to fibroblast growth factor

1990 • 44 citations

Scanning Electron Microscopy of the Adult Rabbit Lens

1976 • 44 citations

Localization of acidic fibroblast growth factor (aFGF) mRNA in mouse and bovine retina by in situ hybridization

1990 • 43 citations

Synthesis of lens capsule and plasma membrane glycoproteins by lens epithelial cells and fibers in the rat

1988 • 42 citations

High molecular weight forms of basic fibroblast growth factor recognized by a new anti‐bFGF antibody

1990 • 41 citations

Immunolocalization of growth factors in the human ciliary body epithelium

1993 • 41 citations

Expression Patterns of Two Fibroblast Growth Factor Receptor Genes during Early Chick Eye Development

1994 • 41 citations

Control of Cell Division in the Ocular Lens, Retina, and Vitreous Humor

1982 • 39 citations

IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages.

1993 • 39 citations

Acidic Fibroblast Growth Factor Distribution in Normal Human Eye and Possible Implications in Ocular Pathogenesis

1990 • 37 citations

The age of rats affects the response of lens epithelial explants to fibroblast growth factor. An ultrastructural analysis.

1992 • 36 citations

Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid.

1995 • 36 citations

Functional characterization of insulin and IGF-I receptors in chicken lens epithelial and fiber cells

1992 • 36 citations

Insulin-like growth factor-1 (IGF-1) specifically binds to bovine lens epithelial cells and increases the number of fibronectin receptor sites

1994 • 35 citations

Distribution of FGF-5 in the rhesus macaque retina.

1994 • 33 citations

Complete Elimination of Mitosis and DNA Synthesis in the Lens of the Hypophysectomized Frog: Effects on Cell Migration and Fiber Growth

1979 • 32 citations

Nuclear pyknosis during lens fibre differentiation in epithelial explants

1986 • 31 citations

aFGF Binding to Low and High Affinity Receptors Induces Both aFGF and aFGF Receptors Dimerization

1993 • 28 citations

Cell replication and terminal differentiation in the embryonic chicken lens: normal and forced initiation of lens fibre formation

1984 • 28 citations

Cell lineage analysis of lens epithelial cells induced to differentiate into fibres

1988 • 27 citations

A morphometric analysis of the development of the rat lens capsule

1989 • 25 citations

A lens fibre differentiation factor from calf neural retina

1986 • 23 citations

Experimental cataract and wound healing in mouse lens.

1973 • 22 citations

The spatial relationship between presumptive lens and optic vesicle/cup during early eye morphogenesis in the rat

1981 • 21 citations

Wound healing in the mouse lens

1981 • 21 citations

Growth control of cornea and lens epithelial cells

1994 • 21 citations

Structure‐Function Studies of Acidic Fibroblast Growth Factor^a

1991 • 19 citations

Aqueous humor of cat contains fibroblast growth factor and transferrin similar to those in man

1990 • 18 citations

Aging and rates of lens-cell differentiation in vivo, measured by a chemical approach.

1989 • 15 citations

Expression of keratinocyte growth factor mRNA in ex vivo and in vitro specimens of human cornea and conjunctiva.

1994 • 14 citations

Analysis of heparan‐sulphate chains and oligosaccharides from proliferating and quiescent fibroblasts

1994 • 13 citations

Analysis of an inductive interaction between lens and neural retina in rats of different ages

1986 • 12 citations

AN AUTORADIOGRAPHIC STUDY ON CELL MIGRATION IN THE EYE LENS EPITHELIUM FROM NORMAL AND ALLOXAN DIABETIC RATS

1965 • 10 citations

Receptors for insulin and IGF-I in bovine lens epithelium.

1990 • 8 citations

Age-related changes in fibre differentiation of rat lens epithelial cells in vitro

1988 • 7 citations

INFLUENCE OF NEURAL RETINA ON LENS FIBRE DIFFERENTIATION IN RATS

1985 • 4 citations

Purification of a basic fibroblast growth factor-binding proteoglycan from bovine cardiac plasma membrane

1993 • 4 citations

Basic fibroblast growth factor, insulin and lens differentiation

1996 • 1 citations