Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1961 • 3,860 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1999 • 790 citations

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1997 • 664 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

1996 • 559 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

1996 • 428 citations

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

1995 • 424 citations

The cell biology of the plasminogen system

1995 • 424 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

1993 • 344 citations

Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome.

1989 • 325 citations

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.

1996 • 306 citations

The value of edema fluid protein measurement in patients with pulmonary edema

1979 • 282 citations

Depressed Bronchoalveolar Urokinase Activity in Patients with Adult Respiratory Distress Syndrome

1990 • 271 citations

Studies on the mechanism of the antifibrinolytic action of tranexamic acid

1981 • 234 citations

Simultaneous or Delayed Administration of Hepatocyte Growth Factor Equally Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin

1997 • 204 citations

Plasminogen and Plasminogen Activators Protect against Renal Injury in Crescentic Glomerulonephritis

1997 • 201 citations

Development and Disease in Proteinase-Deficient Mice

1998 • 177 citations

The Development of Bleomycin-Induced Pulmonary Fibrosis in Mice Deficient for Components of the Fibrinolytic System

2000 • 166 citations

Proteolytic control of growth factor availability

1999 • 157 citations

Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation.

1997 • 154 citations

Exacerbation of antigen-induced arthritis in urokinase-deficient mice.

1998 • 141 citations

Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease.

1986 • 139 citations

Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver

1999 • 138 citations

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

1997 • 126 citations

Basic Fibroblast Growth Factor–Induced Angiogenic Phenotype in Mouse Endothelium

1997 • 121 citations

Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine.

1988 • 116 citations

Ligneous Conjunctivitis in Plasminogen-Deficient Mice

1998 • 105 citations

Treatment of Bleomycin-Induced Pulmonary Fibrosis by Transfer of Urokinase-Type Plasminogen Activator Genes

1999 • 102 citations

The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator.

1993 • 89 citations

A Total Fibrinogen Deficiency Is Compatible with the Development of Pulmonary Fibrosis in Mice

2000 • 88 citations

Intratracheal administration of hepatocyte growth factor/scatter factor stimulates rat alveolar type II cell proliferation in vivo.

1996 • 68 citations

Abnormalities of pathways of fibrin turnover in lung lavage of rats with oleic acid and bleomycin-induced lung injury support alveolar fibrin deposition.

1989 • 61 citations

Experimental murine pulmonary cryptococcosis. Differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of Cryptococcus neoformans.

1994 • 58 citations

Recombinant tissue plasminogen activator in cases with fibrin formation after cataract surgery: a prospective randomised multicentre study

1998 • 57 citations

Bronchoalveolar Lavage Procoagulant Activity in Bleomycin-Induced Lung Injury in Marmosets: Characterization and Relationship to Fibrin Deposition and Fibrosis

1987 • 55 citations

Effects of intrapleural heparin or urokinase on the extent of tetracycline-induced pleural disease.

1995 • 55 citations

Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice

1989 • 47 citations

Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model.

1994 • 39 citations

Polymerization of fibrinogen in murine bleomycin-induced lung injury

1996 • 34 citations

Upregulation of Fibrinolysis by Adenovirus-Mediated Transfer of Urokinase-Type Plasminogen Activator Genes to Lung Cells in Vitro and in Vivo

1999 • 19 citations