Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis

Matrix Metalloproteinases

1999 • 3,774 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Determination of hydroxyproline

1967 • 1,583 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis

2001 • 720 citations

Identification of Novel TGF-β/Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation Approach

2001 • 628 citations

Connective Tissue Growth Factor: What's in a Name?

2000 • 483 citations

Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

2003 • 480 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

Matrix Metalloproteinase Expression and Production by Alveolar Macrophages in Emphysema

1997 • 444 citations

Release and Activity of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease

2002 • 439 citations

TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

2000 • 412 citations

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

2000 • 407 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts

2001 • 397 citations

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

2002 • 391 citations

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

1992 • 378 citations

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

2000 • 303 citations

Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation

2002 • 281 citations

Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases

2002 • 280 citations

Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung

2001 • 261 citations

The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function

2002 • 261 citations

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

2001 • 243 citations

Balance of Matrix Metalloprotease-9 and Tissue Inhibitor of Metalloprotease-1 from Alveolar Macrophages in Cigarette Smokers

2000 • 237 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

1996 • 234 citations

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

2001 • 225 citations

Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

2003 • 209 citations

CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC

2002 • 206 citations

Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin

2001 • 184 citations

Differences in the Fibrogenic Response after Transfer of Active Transforming Growth Factor-β1 Gene to Lungs of “Fibrosis-prone” and “Fibrosis-resistant” Mouse Strains

2002 • 171 citations

Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3

2000 • 167 citations

Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages

2000 • 162 citations

V. TGF-β signaling pathways

2000 • 147 citations

Chronic obstructive pulmonary disease c 2: Pathology and biochemistry of emphysema

2002 • 146 citations

TGF-β signaling from receptors to the nucleus

1999 • 141 citations

Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat

2001 • 140 citations

Regulation of Plasminogen Activator Inhibitor-1 Expression by Transforming Growth Factor-β-induced Physical and Functional Interactions between Smads and Sp1

2000 • 135 citations

Interstitial fibrosis and growth factors.

2000 • 129 citations

A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

2001 • 116 citations

Transforming Growth Factor- β Stabilizes Elastin mRNA by a Pathway Requiring Active Smads, Protein Kinase C- δ , and p38

2002 • 115 citations

Is Smad3 a Major Player in Signal Transduction Pathways Leading to Fibrogenesis?

2001 • 106 citations

Selective Induction of Tissue Inhibitor of Metalloproteinase-1 in Bleomycin-Induced Pulmonary Fibrosis

2001 • 102 citations

Matrix Metalloproteinases 2, 9, and 13, and Tissue Inhibitors of Metalloproteinases 1 and 2 in Experimental Lung Silicosis

1999 • 99 citations

Update in Hematology

2002 • 89 citations

Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes

2002 • 82 citations

The ever-increasing complexity of TGF-β signaling

2002 • 81 citations

Lefty Inhibits Receptor-regulated Smad Phosphorylation Induced by the Activated Transforming Growth Factor-β Receptor

2001 • 80 citations

Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema

2001 • 80 citations

Pathogenesis of lung fibrosis and potential new therapeutic strategies.

1995 • 80 citations

Molecular identification of a TTX-sensitive Ca²⁺current

2001 • 76 citations

Production of Collagenase and Tissue inhibitor of Metalloproteinases by Fibroblasts Derived from Normal and Fibrotic Human Lungs

1992 • 73 citations

Signaling Events Required for Transforming Growth Factor-β Stimulation of Connective Tissue Growth Factor Expression by Cultured Human Lung Fibroblasts

2001 • 67 citations

Tumor Necrosis Factor Receptor Deficiency Alters Matrix Metalloproteinase 13/Tissue Inhibitor of Metalloproteinase 1 Expression in Murine Silicosis

2001 • 55 citations

The Smads: transcriptional regulation and mouse models

2000 • 52 citations

Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-β signaling

2002 • 46 citations

Lefty Contributes to the Remodeling of Extracellular Matrix by Inhibition of Connective Tissue Growth Factor and Collagen mRNA Expression and Increased Proteolytic Activity in a Fibrosarcoma Model

2002 • 38 citations

Spatial-specific TGF-β1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung

1999 • 31 citations

Interstitial Fibrosis and Growth Factors

2000 • 29 citations

Mutation analysis of the Smad3 gene in human ovarian cancers.

1999 • 24 citations

Regulation of human monocyte proMMP-9 production by fetuin, an endogenous TGF-? antagonist

2000 • 22 citations