Focal Adhesion Kinase Is Upstream of Phosphatidylinositol 3-Kinase/Akt in Regulating Fibroblast Survival in Response to Contraction of Type I Collagen Matrices via a β1 Integrin Viability Signaling Pathway

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Integrin Signaling

1999 • 3,705 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Mechanotransduction in Response to Shear Stress

1999 • 560 citations

Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase

1996 • 540 citations

Cellular control lies in the balance of forces

1998 • 530 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

1998 • 496 citations

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis

2001 • 471 citations

Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells

1998 • 420 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1999 • 367 citations

Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts.

1998 • 330 citations

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

2002 • 327 citations

Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions.

1995 • 307 citations

Release of Mechanical Tension Triggers Apoptosis of Human Fibroblasts in a Model of Regressing Granulation Tissue

1999 • 282 citations

Caspase-mediated Cleavage of Focal Adhesion Kinase pp125FAK and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis

1998 • 258 citations

Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades

2003 • 239 citations

MAP Kinase Activation by Flow in Endothelial Cells

1996 • 224 citations

Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase

1997 • 167 citations

β1 Integrin Regulates Fibroblast Viability during Collagen Matrix Contraction through a Phosphatidylinositol 3-Kinase/Akt/Protein Kinase B Signaling Pathway

2002 • 163 citations

SHP-1 Regulates Lck-induced Phosphatidylinositol 3-Kinase Phosphorylation and Activity

1999 • 157 citations

α5β1 Integrin Protects Intestinal Epithelial Cells from Apoptosis through a Phosphatidylinositol 3-Kinase and Protein Kinase B–dependent Pathway

2000 • 155 citations

DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

2002 • 150 citations

Integrin Signaling and Matrix Assembly

1996 • 144 citations

Normal Human Primary Fibroblasts Undergo Apoptosis in Three-Dimensional Contractile Collagen Gels

1998 • 130 citations

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1996 • 128 citations

Src Family Kinases Are Required for Integrin-mediated but Not for G Protein-coupled Receptor Stimulation of Focal Adhesion Kinase Autophosphorylation at Tyr-397

2001 • 122 citations

Induction of Lung Fibroblast Apoptosis by Soluble Fibronectin Peptides

2000 • 70 citations

The focal adhesion targeting sequence is the major inhibitory moiety of Fak-related non-kinase

2001 • 22 citations