Hepatocyte growth factor counteracts transforming growth factor‐β₁, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Genetic control of the circulating concentration of transforming growth factor type beta1

1999 • 749 citations

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

1993 • 706 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

RELATIONSHIP BETWEEN RENAL FUNCTION AND HISTOLOGICAL CHANGES FOUND IN RENAL-BIOPSY SPECIMENS FROM PATIENTS WITH PERSISTENT GLOMERULAR NEPHRITIS

1968 • 652 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

1999 • 623 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

Early role of Fsp1 in epithelial-mesenchymal transformation

1997 • 433 citations

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

1996 • 423 citations

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

2001 • 419 citations

Connective Tissue Growth Factor Induces the Proliferation, Migration, and Tube Formation of Vascular Endothelial Cells In Vitro, and Angiogenesis In Vivo

1999 • 399 citations

Regulation of Connective Tissue Growth Factor Activity in Cultured Rat Mesangial Cells and Its Expression in Experimental Diabetic Glomerulosclerosis

2000 • 390 citations

Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases

2001 • 335 citations

Hepatocyte growth factor: a multifunctional cytokine

1995 • 324 citations

Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis

2000 • 290 citations

Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.

1998 • 259 citations

Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts

2000 • 252 citations

Proteolytic activation of hepatocyte growth factor in response to tissue injury.

1994 • 221 citations

FAT is a component of glomerular slit diaphragms

2001 • 214 citations

Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats

1994 • 208 citations

Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein.

1991 • 203 citations

Regulation of Smad signaling by protein kinase C

2001 • 179 citations

Reciprocal balance of hepatocyte growth factor and transforming growth factor-β1 in renal fibrosis in mice

2000 • 148 citations

Paracrine stimulation of human renal fibroblasts by proximal tubule cells

1998 • 139 citations

Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways

2000 • 133 citations

The course of the remnant kidney model in mice

1999 • 120 citations

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation

2001 • 95 citations

Expression of AQP family in rat kidneys during development and maturation

1997 • 89 citations

Osteopontin expressed by renal tubular epithelium mediates interstitial monocyte infiltration in rats

2000 • 51 citations

Possible pathogenesis of renal fibrosis.

1996 • 34 citations

Interstitial Fibroblast-Like Cells Express Renin-Angiotensin System Components in a Fibrosing Murine Kidney

2002 • 31 citations

Renal fibroblast-like cells in Goodpasture syndrome rats

2001 • 26 citations

Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expressions of c-jun and c-fos: Involvement of protein tyrosine kinase, protein kinase C, and Ca2+

1996 • 24 citations

Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expressions of c-jun and c-fos: Involvement of protein tyrosine kinase, protein kinase C, and Ca2+

1996 • 19 citations

Nucleotide sequence of a cDNA clone for mouse proα 1(I) collagen protein

1985 • 19 citations

Deleted form of hepatocyte growth factor ameliorates the mortality rate of severe thermal injury in rats

1999 • 6 citations