Lovastatin Induces Fibroblast ApoptosisIn Vitro and In Vivo

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

The Adult Respiratory Distress Syndrome

1971 • 774 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Posttranslational modification of proteins by isoprenoids in mammalian cells

1990 • 515 citations

Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.

1987 • 450 citations

Cell cycle-specific effects of lovastatin.

1991 • 301 citations

The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage.

1987 • 297 citations

Induction of Endothelial Cell Apoptosis by TNFα: Modulation by Inhibitors of Protein Synthesis

1994 • 292 citations

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

1994 • 285 citations

Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.

1987 • 239 citations

Role of mesenchymal cell death in lung remodeling after injury.

1993 • 211 citations

Cell cycle-specific effects of tumor necrosis factor.

1984 • 204 citations

Lovastatin Induces Growth Inhibition and Apoptosis in Human Malignant Glioma Cells

1994 • 182 citations

The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth Factors

1986 • 175 citations

Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis.

1990 • 173 citations

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

1998 • 173 citations

Clinical Pharmacokinetics of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors

1996 • 168 citations

Translational Control of Programmed Cell Death: Eukaryotic Translation Initiation Factor 4E Blocks Apoptosis in Growth-Factor-Restricted Fibroblasts with Physiologically Expressed or Deregulated Myc

1996 • 164 citations

Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells.

1995 • 151 citations

Inhibition of Isoprenoid Biosynthesis Induces Apoptosis in Human Promyelocytic HL-60 Cells

1994 • 144 citations

Differential Effects of Monoterpenes and Lovastatin on RAS Processing

1995 • 105 citations

Lovastatin Induces Apoptosis in Malignant Mesothelioma Cells

1998 • 104 citations

Lovastatin-Induced Apoptosis in Prostate Stromal Cells

1997 • 90 citations

Lovastatin reduces expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells

1996 • 90 citations

Cholesterol and mevalonic acid modulation in cell metabolism and multiplication

1992 • 87 citations

Induction of fibroblast apoptosis by anti-CD44 antibody: implications for the treatment of fibroproliferative lung disease.

1996 • 77 citations

Physiological Disposition of Hmg-Coa-Reductase Inhibitors

1990 • 68 citations

Fibroproliferative Disorders

1991 • 58 citations

Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype.

1992 • 55 citations

Inhibition of growth factor signaling pathways by lovastatin

1991 • 51 citations

Lovastatin Disrupts Early Events in Insulin Signaling: A Potential Mechanism of Lovastatins Anti-Mitogenic Activity

1994 • 49 citations

Potential Therapeutic Initiatives for Fibrogenic Lung Diseases

1995 • 47 citations

Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2.

1996 • 41 citations

Inhibition of Proliferative Activity of Pulmonary Fibroblasts by Tetrandrine

1993 • 36 citations

Lovastatin-Induced Apoptosis in Prostate Stromal Cells

1997 • 17 citations

Quantitative image analysis of angiogenesis in rats implanted with a fibrin gel chamber.

1992 • 17 citations

Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2α in Swiss mouse 3T3 cells

1995 • 14 citations

Polymer of proline analogue with sustained antifibrotic activity in lung fibrosis.

1997 • 14 citations

Lovastatin induces apoptosis in a metastatic ovarian tumour cell line.

1996 • 12 citations

Mevalonate modulation of cell proliferation and apoptosis

1997 • 4 citations