The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1
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References (85)
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 • 225,752 citations
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 • 200,127 citations
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 • 3,650 citations
Transforming Growth Factor β in Tissue Fibrosis
1994 • 3,055 citations
Integrins and Signal Transduction Pathways: the Road Taken
1995 • 3,002 citations
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
1992 • 2,969 citations
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
1986 • 2,878 citations
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.
1986 • 2,499 citations
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
1993 • 2,169 citations
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
1994 • 1,950 citations
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
1993 • 1,941 citations
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.
1986 • 1,644 citations
The Molecular and Cellular Biology of Wound Repair
1988 • 1,508 citations
Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.
1990 • 1,176 citations
Fibroblasts, myofibroblasts, and wound contraction
1994 • 1,150 citations
Transforming growth factor-beta in disease: the dark side of tissue repair.
1992 • 1,126 citations
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.
1994 • 984 citations
The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen
1997 • 956 citations
Growth factors in the extracellular matrix
1997 • 879 citations
PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis
1996 • 867 citations
Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.
1990 • 838 citations
Histology for Pathologists
1992 • 820 citations
GRANULATION TISSUE AS A CONTRACTILE ORGAN
1972 • 802 citations
Transforming growth factor-beta: recent progress and new challenges.
1992 • 781 citations
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction
1996 • 772 citations
Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)
1993 • 755 citations
Construction of DNA sequences complementary to rat .alpha.1 and .alpha.2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D
1984 • 568 citations
Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.
1993 • 511 citations
An Orphan Receptor Tyrosine Kinase Family Whose Members Serve as Nonintegrin Collagen Receptors
1997 • 510 citations
Integrin signalling and tyrosine phosphorylation: just the FAKs?
1998 • 502 citations
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.
1989 • 489 citations
Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
1996 • 485 citations
Myofibroblasts differentiate from fibroblasts when plated at low density.
1996 • 482 citations
Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.
1994 • 470 citations
Sequential appearance of fibronectin and collagen in experimental granulation tissue.
1980 • 449 citations
Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.
1994 • 444 citations
Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.
1988 • 420 citations
Integrins, Oncogenes, and Anchorage Independence
1997 • 345 citations
A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors.
1989 • 339 citations
Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.
1995 • 324 citations
A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements
1997 • 297 citations
Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform
1997 • 289 citations
TGF-β signalling through the Smad pathway
1997 • 265 citations
[27] Arginine-glycine-aspartic acid adhesion receptors
1987 • 263 citations
Extracellular matrix regulates expression of the TGF-beta 1 gene.
1993 • 260 citations
Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.
1987 • 247 citations
Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells.
1988 • 244 citations
Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-β and evidence for endogenous TGF-β-like activity
1991 • 229 citations
Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats
1984 • 221 citations
α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon
1992 • 209 citations
Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells.
1987 • 204 citations
The fibronectin gene as a model for splicing and transcription studies
1996 • 198 citations
Modulation of Cell-adhesive Activity of Fibronectin by the Alternatively Spliced EDA Segment
1997 • 189 citations
Transforming growth factor β regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts
1988 • 185 citations
Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis
1997 • 169 citations
Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent.
1989 • 165 citations
Fibronectin‐associated transforming growth factor
1987 • 148 citations
Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment.
1988 • 135 citations
Transforming growth factor‐β regulates the splicing pattern of fibronectin messenger RNA precursor
1990 • 129 citations
The inclusion of the type III repeat ED-B in the fibronectin molecule generates conformational modifications that unmask a cryptic sequence.
1992 • 127 citations
Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects
1996 • 124 citations
The Role of the Myofibroblast in Wound Healing and Fibrocontractive Diseases
1988 • 107 citations
Localization of the cellular‐fibronectin‐specific epitope recognized by the monoclonal antibody IST‐9 using fusion proteins expressed in E. coli
1987 • 92 citations
Expression of fibronectin variants in vascular and visceral smooth muscle cells in development
1990 • 85 citations
Fibronectin mRNA Splice Variant in Articular Cartilage Lacks Bases Encoding the V, III-15, and I-10 Protein Segments
1996 • 80 citations
Modulation of α‐smooth muscle actin expression in fibroblasts by transforming growth factor‐β isoforms: an in vivo and in vitro study
1996 • 79 citations
TGF beta and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin.
1995 • 77 citations
Rat Fibroblasts Cultured from Various Organs Exhibit Differences in α-Smooth Muscle Actin Expression, Cytoskeletal Pattern, and Adhesive Structure Organization
1998 • 75 citations
The Region Encoded by the Alternatively Spliced Exon IIIA in Mesenchymal Fibronectin Appears Essential for Chondrogenesis at the Level of Cellular Condensation
1997 • 67 citations
Fibronectin Type III5 Repeat Contains a Novel Cell Adhesion Sequence, KLDAPT, Which Binds Activated α4β1 and α4β7 Integrins
1997 • 67 citations
Expression of fibronectin ED-A+ and ED-B+ isoforms by human and experimental colorectal cancer. Contribution of cancer cells and tumor-associated myofibroblasts.
1996 • 66 citations
TGFβ and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin
1995 • 63 citations
Fibronectin Type III Repeats Mediate RGD-independent Adhesion and Signaling through Activated β1 Integrins
1997 • 61 citations
Transforming Growth Factor β Increases Cell Surface Binding and Assembly of Exogenous (Plasma) Fibronectin by Normal Human Fibroblasts
1988 • 60 citations
A simplified procedure for the preparation of antibodies to serum fibronectin
1980 • 59 citations
Tumor targeting potential of the monoclonal antibody BC‐1 against oncofetal fibronectin in nude mice bearing human tumor implants
1997 • 52 citations
Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance.
1990 • 45 citations
Cellular retinol-binding protein-1 is transiently expressed in granulation tissue fibroblasts and differentially expressed in fibroblasts cultured from different organs.
1997 • 44 citations
Plasminogen Activator Expression in Rat Arterial Smooth Muscle Cells Depends on Their Phenotype and Is Modulated by Cytokines
1998 • 41 citations
Tumor targeting potential of the monoclonal antibody BC-1 against oncofetal fibronectin in nude mice bearing human tumor implants
1997 • 38 citations
Adhesion Activity in Fibronectin's Alternatively Spliced Domain EDa (EIIIA) and Its Neighboring Type III Repeats: Oncogene-Dependent Regulation
1994 • 37 citations
A pilot pharmacokinetic and immunoscintigraphic study with the technetium-99m-labeled monoclonal antibody BC-1 directed against oncofetal fibronectin in patients with brain tumors
1997 • 34 citations
Cloned cdna sequence for the human mesothelial protein ‘mesosecrin’ discloses its identity as a plasminogen activator inhibitor (PAI-1) and a recent evolutionary change in transcript processing
1989 • 32 citations
DNA Repair Defect Tied to Mutated TGF-β Receptor Gene
1995 • 18 citations
[24] Extracellular matrix assembly
1994 • 13 citations