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1999 • 5,878 citations

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Matrix Metalloproteinases: A Review

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Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

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A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

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Tissue inhibitors of metalloproteinases: evolution, structure and function

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Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

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Idiopathic Pulmonary Fibrosis

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SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

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H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis

1998 • 1,037 citations

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

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Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

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The epidemiology of interstitial lung diseases.

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Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis.

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Hepatocyte growth factor gene therapy of liver cirrhosis in rats

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A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

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Impaired wound healing in mice with a disrupted plasminogen gene

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Increased Prevalence of Gastroesophageal Reflux in Patients with Idiopathic Pulmonary Fibrosis

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Cryptogenic fibrosing alveolitis: clinical features and their influence on survival

1980 • 529 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

Upregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD

2000 • 508 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

An Immunohistochemical Study of Architectural Remodeling and Connective Tissue Synthesis in Pulmonary Fibrosis

1989 • 469 citations

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

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Treatment of Idiopathic Pulmonary Fibrosis with a New Antifibrotic Agent, Pirfenidone

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1989 • 422 citations

Azathioprine Combined with Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis: A Prospective Double-blind, Randomized, Placebo-controlled Clinical Trial

1991 • 416 citations

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The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.

1991 • 406 citations

Idiopathic Pulmonary Fibrosis

1998 • 404 citations

Proteolysis and cell migration: creating a path?

1999 • 389 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

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The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

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Platelet-derived growth factor in idiopathic pulmonary fibrosis.

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Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation.

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Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

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Occupational and Environmental Risk Factors for Idiopathic Pulmonary Fibrosis: A Multicenter Case-Control Study

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1996 • 343 citations

Determinants of survival in idiopathic pulmonary fibrosis.

1994 • 333 citations

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1996 • 329 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

1996 • 326 citations

Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis

1996 • 313 citations

Complex role of matrix metalloproteinases in angiogenesis

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The Clinical Management of Sarcoidosis A 50-Year Experience at the Johns Hopkins Hospital

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Chronic diffuse interstitial lung disease: diagnostic value of chest radiography and high-resolution CT.

1991 • 302 citations

Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?

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Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic fibrosing alveolitis.

1989 • 296 citations

Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung

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Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis.

1988 • 287 citations

Circulating Immune Complexes in the Idiopathic Interstitial Pneumonias

1978 • 281 citations

Antioxidative and Clinical Effects of High-doseN-Acetylcysteine in Fibrosing Alveolitis

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1980 • 254 citations

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1981 • 253 citations

Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy.

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1980 • 250 citations

Neutralization of the CXC Chemokine, Macrophage Inflammatory Protein-2, Attenuates Bleomycin-Induced Pulmonary Fibrosis

1999 • 243 citations

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Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis.

1979 • 237 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

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Precapillary Systemic-pulmonary Anastomoses

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IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis.

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Adult familial cryptogenic fibrosing alveolitis in the United Kingdom

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1990 • 228 citations

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1985 • 200 citations

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The Detection of Epstein-Barr Virus DNA in Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis

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Idiopathic Pulmonary Fibrosis and High Prevalence of Serum Antibodies to Hepatitis C Virus

1992 • 186 citations

Colchicine versus Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis

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Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis

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Alveolitis and Collapse in the Pathogenesis of Pulmonary Fibrosis

1989 • 178 citations

Keratinocyte growth factor reduces lung damage due to acid instillation in rats.

1996 • 178 citations

Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury

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Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

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Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis.

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Alveolitis: the key to the interstitial lung disorders.

1982 • 174 citations

Familial Idiopathic Pulmonary Fibrosis

1986 • 172 citations

Matrix‐degrading proteases and angiogenesis during development and tumor formation

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1987 • 167 citations

Idiopathic pulmonary fibrosis: progression of honeycombing at thin-section CT.

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Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis.

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Prognostic Role of Eosinophils in Pulmonary Fibrosis

1987 • 163 citations

A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease.

1987 • 163 citations

Tissue Factor Expression and Fibrin Deposition in the Lungs of Patients with Idiopathic Pulmonary Fibrosis and Systemic Sclerosis

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Disease Progression in Usual Interstitial Pneumonia Compared With Desquamative Interstitial Pneumonia

1996 • 151 citations

Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.

1995 • 146 citations

Corticosteroids and the Treatment of Idiopathic Pulmonary Fibrosis

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Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro

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Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease.

1986 • 139 citations

Pulmonary fibrosis deaths in the United States, 1979-1991. An analysis of multiple-cause mortality data.

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Colchicine, D-Penicillamine, and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis

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Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides

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Interstitial Lung Disease

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Surfactant protein A predicts survival in idiopathic pulmonary fibrosis.

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Role of Interleukin-10 in the Lung Response to Silica in Mice

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Accuracy of the typical computed tomographic appearances of fibrosing alveolitis.

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Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism

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Idiopathic Pulmonary Fibrosis: Abnormalities in the Bronchoalveolar Lavage Content of Surfactant Protein A

1991 • 112 citations

Idiopathic Pulmonary Fibrosis and Hepatitis C Virus Infection

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CRYPTOGENIC FIBROSING ALVEOLITIS AND EPSTEIN-BARR VIRUS: AN ASSOCIATION?

1984 • 109 citations

α1-ANTITRYPSIN PHENOTYPES IN FIBROSING ALVEOLITIS AND RHEUMATOID ARTHRITIS

1977 • 109 citations

Fibrosing alveolitis: chest radiography and CT as predictors of clinical and functional impairment at follow-up in 26 patients.

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Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin

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1976 • 103 citations

Lovastatin Induces Fibroblast ApoptosisIn Vitro and In Vivo

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1978 • 100 citations

Concentration, biosynthesis and degradation of collagen in idiopathic pulmonary fibrosis.

1986 • 98 citations

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Incidence of hepatitis C virus infection in Italian patients with idiopathic pulmonary fibrosis.

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Exponential description of the static pressure-volume curve of normal and diseased lungs.

1979 • 87 citations

Functional impairment in lone cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a comparison.

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Colchicine Suppresses the Release of Fibroblast Growth Factors from Alveolar MacrophagesIn Vitro: The Basis of a Possible Therapeutic Approach to the Fibrotic Disorders

1988 • 84 citations

Colchicine in the Treatment of Pulmonary Fibrosis

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Extracellular Glutathione Suppresses Human Lung Fibroblast Proliferation

1990 • 81 citations

Immunohistochemical and gelatin zymography studies for matrix metalloproteinases in bleomycin‐induced pulmonary fibrosis

1998 • 80 citations

Exposure to Commonly Prescribed Drugs and the Etiology of Cryptogenic Fibrosing Alveolitis

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Antiinflammatory and Antifibrotic Properties of Colchicine: Implications for Idiopathic Pulmonary Fibrosis

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Expression of tumour necrosis factor‐α in cryptogenic fibrosing alveolitis

1993 • 76 citations

Increased expression of gelatinases and collagenase in rat lungs exposed to 100% oxygen.

1996 • 76 citations

Antisense Oligonucleotides Demonstrate a Dominant Role of c-Ki-RAS Proteins in Regulating the Proliferation of Diploid Human Fibroblasts

1996 • 73 citations

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1999 • 73 citations

Serial High Resolution CT Findings in Nonspecific Interstitial Pneumonia/Fibrosis

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1979 • 71 citations

Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns.

1990 • 68 citations

Lymphocyte phenotypes in bronchoalveolar lavage and lung tissue in sarcoidosis and idiopathic pulmonary fibrosis.

1986 • 66 citations

Captopril Inhibits Proliferation of Human Lung Fibroblasts in Culture: A Potential Antifibrotic Mechanism

1994 • 62 citations

Viruses and idiopathic pulmonary fibrosis

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Pulmonary mechanics in diffuse fibrosing alveolitis.

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Genetic Studies in Familial Fibrosing Alveolitis

1986 • 53 citations

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Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A

1989 • 47 citations

Potential Therapeutic Initiatives for Fibrogenic Lung Diseases

1995 • 47 citations

Colchicine-Induced Modulation of Collagenase in Human Skin Fibroblast Cultures. I. Stimulation of Enzyme Synthesis in Normal Cells

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Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.

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Usual Interstitial Pneumonia Following Texas A2 Influenza Infection

1981 • 45 citations

Analysis of interferon-γ-dependent and -independent pathways of macrophage activation

2000 • 45 citations

The pattern of breathing in diffuse lung fibrosis.

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Surfactant components modulate fibroblast apoptosis and type I collagen and collagenase-1 expression

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1980 • 42 citations

Immunofluorescent patterns in the idiopathic interstitial pneumonias.

1978 • 41 citations

Three Sensitive Methods for the Detection of Cytomegalovirus in Lung Tissue of Patients with Interstitial Pneumonitis

1990 • 41 citations

Expression of class II major histocompatibility complex antigens on alveolar epithelium in interstitial lung disease: relevance to pathogenesis of idiopathic pulmonary fibrosis.

1987 • 38 citations

Idiopathic Pulmonary Fibrosis: Current Clinical Concepts and Challenges in Management

1994 • 38 citations

Comparative inhibitory effects of bucillamine and d‐penicillamine on the function of human b cells and t cells

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Influenza Virus Infection, Ozone Exposure, and Fibrogenesis

1990 • 35 citations

Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment.

1998 • 34 citations

Bronchial Lavage in Inflammatory Lung Disease

1983 • 33 citations

Lung alveolar epithelial cells synthesize interstitial collagenase and gelatinases A and B in vitro

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Upregulation of acidic fibroblast growth factor during development of experimental lung fibrosis

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Collagen accumulation in irradiated rat lung: modification by D-penicillamine.

1983 • 32 citations

Sequential Virus Infections, Bacterial Superinfections, and Fibrogenesis

1990 • 31 citations

D-Penicillamine Prevents Collagen Accumulation in Lungs of Rats Given Bleomycin

1986 • 29 citations

Immunohistochemical evidence for loss of ICAM-1 by alveolar epithelial cells in pulmonary fibrosis

1995 • 28 citations

Distribution of HLA antigens in idiopathic pulmonary fibrosis.

1978 • 24 citations

[Long-term follow-up of lung function parameters in patients with idiopathic pulmonary fibrosis treated with prednisone and azathioprin or d-penicillamine (author's transl)].

1979 • 22 citations

Effects of interferons on proliferation and collagen synthesis of rat palatal wound fibroblasts

1999 • 20 citations

Hypothesis: exposure to solvents may cause fibrosing alveolitis

1994 • 19 citations

Alpha1-antitrypsin phenotypes in patients with cryptogenic fibrosing alveolitis: a case-control study

1997 • 18 citations

Effects of the 21-aminosteroid, U74389F, on bleomycin-induced pulmonary fibrosis in rats

1994 • 16 citations

Inherited Forms of Interstitial Lung Disease

1982 • 13 citations

Fibroblast Inhibition Does Not Promote Normal Lung Repair After Hyperoxia

1994 • 13 citations

Familial fibrosing alveolitis

1981 • 12 citations

Interferon-β, an autocrine cytokine, suppresses human fetal skin fibroblast migration into a denuded area in a cell monolayer but is not involved in the age-related decline of cell migration

1996 • 7 citations

Genetic Aspects of Idiopathic Pulmonary Fibrosis and Hypersensitivity Pneumonitis

1986 • 7 citations