Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis

1987 • 420 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure.

1993 • 329 citations

Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

1995 • 306 citations

Pulmonary Response to Silica or Titanium Dioxide: Inflammatory Cells, Alveolar Macrophage-derived Cytokines, and Histopathology

1990 • 249 citations

Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters.

1995 • 213 citations

Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.

1990 • 179 citations

TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression.

1995 • 119 citations

Differential Production of Tumor Necrosis Factor, Macrophage Colony Stimulating Factor, and Interleukin 1 by Human Alveolar Macrophages

1989 • 115 citations

Lung Fibrosis is Ameliorated by Pirfenidone Fed in Diet After the Second Dose In A Three-Dose Bleomycin-Hamster Model

1998 • 104 citations

Differential Proliferation of Rat Lung Fibroblasts Induced by the Platelet-derived Growth Factor-AA, -AB, and -BB Isoforms Secreted by Rat Alveolar Macrophages

1991 • 103 citations

Bleomycin stimulation of cytokine secretion by the human alveolar macrophage

1992 • 99 citations

Acute lung injury. Pathogenesis of intraalveolar fibrosis.

1991 • 98 citations

Increased Expression of Platelet-Derived Growth Factor A and Insulin-Like Growth Factor-I in BAL Cells During the Development of Bleomycin-Induced Pulmonary Fibrosis in Mice

1996 • 97 citations

Pathogenesis of Pulmonary Fibrosis in Interstitial Lung Disease: Alveolar Macrophage PDGF(B) Gene Activation and Up-regulation by Interferon Gamma

1991 • 91 citations

Presence of Platelet-derived Growth Factor in Normal and Fibrotic Lung Is Specifically Associated with Interstitial Macrophages, While Both Interstitial Macrophages and Alveolar Epithelial Cells Express the c-sis Proto-oncogene

1991 • 87 citations

Growth factor and procollagen type I gene expression in human liver disease

1995 • 87 citations

Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice

1997 • 75 citations

Variable Expression of Platelet-derived Growth Factor Family Proteins in Acute Lung Injury

1993 • 57 citations

Analysis of Bronchoalveolar Lavage Fluid from Bleomycin-Induced Pulmonary Fibrosis in Hamsters

1986 • 52 citations

Chrysotile asbestos stimulates platelet-derived growth factor-AA production by rat lung fibroblasts in vitro: evidence for an autocrine loop.

1995 • 47 citations

Intra-alveolar Release of a Competence-type Growth Factor after Lung Injury^1–3

1986 • 33 citations

Regulated expression of PDGF A-chain mRNA in human saphenous vein smooth muscle cells

1991 • 27 citations

Spontaneous production of PDGF A-chain homodimer by rat lung fibroblasts in vitro

1992 • 26 citations

Deleted Work

1955 • 0 citations