Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Cloning and characterization of five overlapping cDNAs specific for the human proα 1(I) collagen chain

1982 • 496 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Biochemical Composition of the Connective Tissue in Keloids and Analysis of Collagen Metabolism in Keloid Fibroblast Cultures

1985 • 263 citations

Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta

1988 • 243 citations

Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

1988 • 241 citations

Scleroderma

1979 • 241 citations

Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridization

1988 • 207 citations

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.

1987 • 195 citations

Cloning a cDNA for the pro-alpha 2 chain of human type I collagen.

1981 • 192 citations

A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer?

1989 • 181 citations

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

1987 • 181 citations

Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro

1989 • 178 citations

Identification of Fibroblasts Responsible for Increased Collagen Production in Localized Scleroderma by In Situ Hybridization

1988 • 176 citations

Evaluation of Transforming Growth Factor β and Type I Procollagen Gene Expression in Fibrotic Skin Disease by In Situ Hybridization

1990 • 155 citations

Transcriptional control of human diploid fibroblast collagen synthesis by γ-interferon

1984 • 132 citations

Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

1990 • 127 citations

Extracellular Matrix of the Skin: 50 Years of Progress

1989 • 120 citations

Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts

1987 • 117 citations

Growth factors. Their biology and promise in dermatologic diseases and tissue repair

1989 • 110 citations

Tumor necrosis factor inhibits collagen and fibronectin synthesis in human dermal fibroblasts

1988 • 90 citations

Tumor necrosis factor receptors in HeLa cells and their regulation by interferon-gamma.

1986 • 86 citations

Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated wth decreaded levels of the procollagen mRNAs(FEBS 2156)

1985 • 83 citations

Increased type I collagen mRNA levels in cultured scleroderma fibroblasts

1984 • 76 citations

Elevated proα2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene

1987 • 57 citations

Regulation of Elastin Gene Expression: Evidence for Functional Promoter Activity in the 5′-Flanking Region of the Human Gene

1990 • 45 citations

Regulation of Collagen Gene Expression in Cutaneous Diseases With Dermal Fibrosis: Evidence for Pretranslational Control

1987 • 43 citations

Eosinophilic Fasciitis

1990 • 28 citations