Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

1998 • 740 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Apoptosis in podocytes induced by TGF-β and Smad7

2001 • 574 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Thrombospondins as matricellular modulators of cell function

2001 • 463 citations

Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

1999 • 441 citations

The functions of thrombospondin-1 and-2

2000 • 435 citations

Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

1999 • 419 citations

TGF-β receptor signaling

1997 • 417 citations

p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

2000 • 416 citations

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1999 • 388 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

1999 • 347 citations

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice

2000 • 340 citations

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

2000 • 263 citations

Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase

2000 • 247 citations

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

1996 • 245 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

Transforming Growth Factor-β Induces Collagenase-3 Expression by Human Gingival Fibroblasts via p38 Mitogen-activated Protein Kinase

1999 • 214 citations

Disruption of the antiproliferative TGF-β signaling pathways in human pancreatic cancer cells

1998 • 190 citations

GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells

2001 • 161 citations

Apoptosis in podocytes induced by TGF-β and Smad7

2001 • 154 citations

Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding

2002 • 153 citations

X-linked Inhibitor of Apoptosis Protein Functions as a Cofactor in Transforming Growth Factor-β Signaling

2001 • 148 citations

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.

1997 • 145 citations

The gadd and MyD Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell Growth

1994 • 119 citations

The Role of p38 MAP Kinase in TGF-β1-Induced Signal Transduction in Human Neutrophils

1998 • 107 citations

p38-mediated Regulation of an Fas-associated Death Domain Protein-independent Pathway Leading to Caspase-8 Activation during TGFβ-induced Apoptosis in Human Burkitt Lymphoma B Cells BL41

2001 • 87 citations

Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway

2001 • 81 citations

TGFβ1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

2000 • 78 citations

Increased tumorigenicity in the human pancreatic cell line MIA PaCa‐2 Is associated with an aberrant regulation of an IGF‐1 autocrine loop and lack of expression of the TGF‐β type RII receptor

1995 • 58 citations

Smad4 mediates activation of mitogen-activated protein kinases by TGF-β in pancreatic acinar cells

2001 • 58 citations

Activation of p38MAPK by TGF‐β in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death

2001 • 38 citations

The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression

2000 • 27 citations