Role of matrix metalloproteinases in epithelial migration

Integrins

2002 • 8,127 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Matrix metalloproteinases and the regulation of tissue remodelling

2007 • 2,742 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Collective cell migration in morphogenesis, regeneration and cancer

2009 • 2,503 citations

The epithelial–mesenchymal transition: new insights in signaling, development, and disease

2006 • 1,987 citations

Matrix metalloproteinases as modulators of inflammation and innate immunity

2004 • 1,833 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

1962 • 1,275 citations

Matrix metalloproteinases: they're not just for matrix anymore!

2001 • 1,257 citations

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

1997 • 1,227 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Matrix metalloproteinases: a tail of a frog that became a prince

2002 • 1,082 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Extracellular matrix remodelling: the role of matrix metalloproteinases

2003 • 1,061 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

2002 • 741 citations

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

2002 • 734 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

One-dimensional topography underlies three-dimensional fibrillar cell migration

2009 • 701 citations

Metalloproteinases and their inhibitors: Regulators of wound healing

2007 • 693 citations

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 • 685 citations

Membrane Type I Matrix Metalloproteinase Usurps Tumor Growth Control Imposed by the Three-Dimensional Extracellular Matrix

2003 • 659 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

2009 • 636 citations

Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength

1993 • 603 citations

The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

1997 • 600 citations

Control of matrix metalloproteinase catalytic activity

2007 • 597 citations

Spatiotemporal Feedback between Actomyosin and Focal-Adhesion Systems Optimizes Rapid Cell Migration

2006 • 595 citations

Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

2000 • 588 citations

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

2007 • 548 citations

Wound Healing: Biochemical and Clinical Aspects

1993 • 535 citations

New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity

1999 • 522 citations

Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

2007 • 449 citations

Breaching the basement membrane: who, when and how?

2008 • 431 citations

The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.

1989 • 422 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

Targeted Disruption of the Matrix Metalloproteinase-9 Gene Impairs Smooth Muscle Cell Migration and Geometrical Arterial Remodeling

2002 • 419 citations

Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement

2004 • 414 citations

Proteases in invasion: matrix metalloproteinases

2001 • 413 citations

HUMAN WOUND REPAIR

1968 • 396 citations

Cleavage of Syndecan-1 by Membrane Type Matrix Metalloproteinase-1 Stimulates Cell Migration

2003 • 382 citations

The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases

2007 • 367 citations

A PATTERN OF EPIDERMAL CELL MIGRATION DURING WOUND HEALING

1971 • 365 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

In search of partners: linking extracellular proteases to substrates

2007 • 340 citations

The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin

2008 • 340 citations

MT1-MMP–dependent neovessel formation within the confines of the three-dimensional extracellular matrix

2004 • 337 citations

Matrix Metalloproteinases (MMPs) and Their Physiological Inhibitors (TIMPs) Are Differentially Expressed during Excisional Skin Wound Repair

1998 • 331 citations

Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

1993 • 319 citations

Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

2003 • 314 citations

Matrix Metalloproteinase Gelatinase B (MMP-9) Coordinates and Effects Epithelial Regeneration

2002 • 291 citations

Matrilysin expression and function in airway epithelium.

1998 • 277 citations

Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties

2008 • 274 citations

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates

2004 • 271 citations

Regulation of substrate adhesion dynamics during cell motility

2002 • 268 citations

Epilysin, a Novel Human Matrix Metalloproteinase (MMP-28) Expressed in Testis and Keratinocytes and in Response to Injury

2001 • 265 citations

Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-Derived MMP

2005 • 260 citations

Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

2003 • 258 citations

Cell polarity triggered by cell-cell adhesion via E-cadherin

2009 • 243 citations

Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.

1994 • 238 citations

Identification and Enzymatic Characterization of Two Diverging Murine Counterparts of Human Interstitial Collagenase (MMP-1) Expressed at Sites of Embryo Implantation

2001 • 237 citations

Airway Epithelial Cell Migration Dynamics: MMP-9 Role in Cell–Extracellular Matrix Remodeling

1999 • 233 citations

The cell surface: the stage for matrix metalloproteinase regulation of migration

2002 • 232 citations

Impaired Wound Contraction in Stromelysin-1–Deficient Mice

1999 • 232 citations

Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

1999 • 226 citations

Expression of Matrix Metalloproteinases during Rat Skin Wound Healing: Evidence that Membrane Type-1 Matrix Metalloproteinase Is a Stromal Activator of Pro-Gelatinase A

1997 • 225 citations

Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.

1998 • 217 citations

MMP-13 Plays a Role in Keratinocyte Migration, Angiogenesis, and Contraction in Mouse Skin Wound Healing

2009 • 213 citations

Pro-collagenase-1 (Matrix Metalloproteinase-1) Binds the α2β1 Integrin upon Release from Keratinocytes Migrating on Type I Collagen

2001 • 209 citations

Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury.

1996 • 203 citations

Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers.

1996 • 200 citations

Gelatinase B Is Required for Alveolar Bronchiolization after Intratracheal Bleomycin

2000 • 185 citations

Classical cadherins control nucleus and centrosome position and cell polarity

2009 • 179 citations

Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation

2006 • 177 citations

Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion.

2001 • 168 citations

Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis

2009 • 160 citations

Centrosome positioning and directionality of cell movements

1997 • 145 citations

Metadegradomics

2008 • 143 citations

Stimulation of MMP-7 (matrilysin) byHelicobacter pyloriin human gastric epithelial cells: role in epithelial cell migration

2003 • 141 citations

Secreted Versus Membrane-anchored Collagenases

2009 • 141 citations

Activities of the Matrix Metalloproteinase Stromelysin-2 (MMP-10) in Matrix Degradation and Keratinocyte Organization in Wounded Skin

2004 • 140 citations

Collagenase Expression Is Rapidly Induced in Wound-Edge Keratinocytes After Acute Injury in Human Skin, Persists During Healing, and Stops at Re-Epithelialization

1995 • 136 citations

Syndecans and cell adhesion

2001 • 130 citations

Integrin α2β1 Is Required for Regulation of Murine Wound Angiogenesis but Is Dispensable for Reepithelialization

2006 • 122 citations

Epilysin (MMP-28) Expression is Associated with Cell Proliferation During Epithelial Repair

2002 • 120 citations

MMP7 Shedding of Syndecan-1 Facilitates Re-Epithelialization by Affecting α2β1 Integrin Activation

2009 • 115 citations

Induction and Repression of Collagenase-1 by Keratinocytes Is Controlled by Distinct Components of Different Extracellular Matrix Compartments

1997 • 112 citations

Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis

2007 • 101 citations

Fibrinogen and Fibrin are Anti-Adhesive for Keratinocytes: A Mechanism for Fibrin Eschar Slough During Wound Repair

2001 • 99 citations

Matrilysin (MMP-7) expression in renal tubular damage: Association with Wnt4

2004 • 95 citations

A Proteomic Approach for the Identification of Cell-surface Proteins Shed by Metalloproteases

2002 • 94 citations

Differential Expression of Three Matrix Metalloproteinases, MMP-19, MMP-26, and MMP-28, in Normal and Inflamed Intestine and Colon Cancer

2004 • 89 citations

MMP-9 Sheds the β2 Integrin Subunit (CD18) from Macrophages

2008 • 85 citations

Collagen Dissolution by Keratinocytes Requires Cell Surface Plasminogen Activation and Matrix Metalloproteinase Activity

2002 • 78 citations

Wound Healing in the α2β1 Integrin-Deficient Mouse: Altered Keratinocyte Biology and Dysregulated Matrix Metalloproteinase Expression

2006 • 74 citations

Stromelysin-1-Deficient Fibroblasts Display Impaired Contractionin Vitro

1999 • 66 citations

Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients

2008 • 66 citations

Immunolocalization and gene expression of matrilysin during corneal wound healing.

1999 • 66 citations

Matrilysin-dependent Elastolysis by Human Macrophages

2003 • 65 citations

Matrilysin (Matrix Metalloproteinase-7) Regulates Anti-Inflammatory and Antifibrotic Pulmonary Dendritic Cells That Express CD103 (αEβ7-Integrin)

2009 • 64 citations

Reduced migration, altered matrix and enhanced TGFβ1 signaling are signatures of mouse keratinocytes lacking Sdc1

2007 • 64 citations

Transforming growth factor-β1 increases airway wound repair via MMP-2 upregulation: a new pathway for epithelial wound repair?

2006 • 62 citations

Matrix Metalloproteinase Inhibitor BB-3103 Unlike the Serine Proteinase Inhibitor Aprotinin Abrogates Epidermal Healing of Human Skin Wounds Ex Vivo11Presented in part at the 10th Annual Meeting of the European Tissue Repair Society (ETRS) May 24–28, 2000 in Brussels, Belgium and at the 35th Congress of the European Society for Surgical Research (ESSR) June 1–3, 2000 in Malmö, Sweden and abstract published in Eur Surg Res 32 (Suppl. 1):2–3, 2000.

2002 • 58 citations

MMP‐14 mediated MMP‐9 expression is involved in TGF‐beta1‐induced keratinocyte migration

2008 • 54 citations

Tissue Inhibitor of Metalloproteinase-1 Moderates Airway Re-Epithelialization by Regulating Matrilysin Activity

2008 • 53 citations

Corneal Neovascularization after Excimer Keratectomy Wounds in Matrilysin-Deficient Mice

2003 • 49 citations

Cell Surface-bound Collagenase-1 and Focal Substrate Degradation Stimulate the Rear Release of Motile Vascular Smooth Muscle Cells

2000 • 46 citations

Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma

2007 • 45 citations

Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury

2007 • 44 citations

Epithelial migration in organ culture. A morphological and time lapse cinematographic analysis of migrating stratified squamous epithelium

1978 • 31 citations

What Is the α2β1 Integrin Doing in the Epidermis?

2007 • 31 citations

Membrane-type 1 matrix metalloproteinase-mediated progelatinase A activation in non-tumorigenic and tumorigenic human keratinocytes

2000 • 31 citations

MMP‐2, TIMP‐2 and MT1‐MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB‐light

2002 • 27 citations

Membrane Type 1 Matrix Metalloproteinase Regulates Cellular Invasiveness and Survival in Cutaneous Epidermal Cells

2002 • 20 citations

Matrix Metalloproteinase-21 Expression Is Associated with Keratinocyte Differentiation and Upregulated by Retinoic Acid in HaCaT Cells

2008 • 13 citations