Prostaglandin E₂Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Characterization of a New Human Diploid Cell Strain, IMR-90

1977 • 371 citations

Factors influencing myofibroblast differentiation during wound healing and fibrosis.

1995 • 273 citations

Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells.

1989 • 265 citations

Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

2001 • 248 citations

Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators.

1986 • 235 citations

Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.

1996 • 230 citations

α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

1992 • 209 citations

Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis.

1995 • 167 citations

Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis.

1994 • 164 citations

Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma.

1995 • 153 citations

GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism

2000 • 147 citations

Ligands of Peroxisome Proliferator-activated Receptor-γ Block Activation of Pancreatic Stellate Cells

2002 • 135 citations

Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts.

1992 • 133 citations

Augmentation of Functional Prostaglandin E Levels on the Respiratory Epithelial Surface by Aerosol Administration of Prostaglandin E

1991 • 129 citations

Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis.

1993 • 125 citations

Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE₂

2003 • 112 citations

Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process.

1985 • 110 citations

The Differential Effect of Prostaglandin E2 on Transforming Growth Factor-β and Insulin-induced Collagen Formation in Lung Fibroblasts

1989 • 110 citations

Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products.

1983 • 106 citations

Alpha-smooth muscle actin in parenchymal cells of bleomycin-injured rat lung.

1989 • 104 citations

Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta.

1997 • 102 citations

Different Expression of TNF- α Receptors and Prostaglandin E₂Production in Normal and Fibrotic Lung Fibroblasts

2000 • 94 citations

Modulation of collagen production following bleomycin-induced pulmonary fibrosis in hamsters. Presence of a factor in lung that increases fibroblast prostaglandin E2 and cAMP and suppresses fibroblast proliferation and collagen production.

1982 • 91 citations

Myofibroblast differentiation during fibrosis.

1995 • 87 citations

Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts.

1998 • 69 citations

Modulation of collagen production by fibroblasts. Effects of chronic exposure to agonists that increase intracellular cyclic AMP

1982 • 56 citations

Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen α1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts

1998 • 56 citations

Mechanisms of Pulmonary Fibrosis

2001 • 54 citations

Actin-containing cells in human pulmonary fibrosis.

1981 • 45 citations

Role of the myofibroblast in pulmonary fibrosis.

1996 • 42 citations

OPC-13013, a cyclic nucleotide phosphodiesterase type III inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells

1999 • 29 citations

Unsaturated fatty acid effect on cyclic amp levels in human embryo lung fibroblasts

1979 • 13 citations