Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Tumor necrosis factor.

1992 • 601 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

1995 • 364 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

The intratracheal administration of endotoxin and cytokines. I. Characterization of LPS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1-, and TNF-induced inflammatory infiltrate.

1991 • 303 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

Factors influencing myofibroblast differentiation during wound healing and fibrosis.

1995 • 273 citations

Compartmentalization of Intraalveolar and Systemic Lipopolysaccharide-Induced Tumor Necrosis Factor and the Pulmonary Inflammatory Response

1989 • 244 citations

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.

1996 • 229 citations

Arrested Lung Morphogenesis in Transgenic Mice Bearing an SP-C–TGF-β1 Chimeric Gene

1996 • 225 citations

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

1993 • 188 citations

Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat.

1993 • 185 citations

Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis.

1995 • 167 citations

Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts

1991 • 154 citations

Plasmin regulates the activation of cell-associated latent TGF-beta 1 secreted by rat alveolar macrophages after in vivo bleomycin injury.

1996 • 149 citations

Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.

1995 • 146 citations

Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.

1997 • 124 citations

Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.

1994 • 106 citations

Transforming Growth Factor-β Gene Transfer to the Lung Induces Myofibroblast Presence and Pulmonary Fibrosis

1999 • 98 citations

Tumor necrosis factor inhibits collagen and fibronectin synthesis in human dermal fibroblasts

1988 • 90 citations

Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFα

1997 • 69 citations

Secretion and mRNA expression of TNF alpha and IL-6 in the lungs of pneumoconiosis patients.

1995 • 52 citations

Tumor necrosis factor-alpha, interleukin-8 and chemotactic cytokines.

1990 • 40 citations

Transient Gene Transfer and Expression in the Lung

1997 • 9 citations

Deleted Work

1955 • 0 citations