Back to search

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

Data up to Jan 2025

Published2004
Citations524
References55

Total Citations Per Year

Abstract

References (55)

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000 • 2,535 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis

1998 • 1,037 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

The epidemiology of interstitial lung diseases.

1994 • 912 citations

Imatinib Mesylate — A New Oral Targeted Therapy

2002 • 840 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

international consensus statement

2000 • 794 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

TGF-β and fibrosis

1999 • 579 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia.

2002 • 459 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

TGF-β1-mediated fibroblast–myofibroblast terminal differentiation—the role of smad proteins

2003 • 360 citations

Fibrosis of the Lung and Other Tissues: New Concepts in Pathogenesis and Treatment

2001 • 325 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

Smad3 Mediates Transforming Growth Factor-β–Induced α-Smooth Muscle Actin Expression

2003 • 304 citations

The Relationship between Individual Histologic Features and Disease Progression in Idiopathic Pulmonary Fibrosis

2002 • 295 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase

2000 • 247 citations

Role of Cytokines and Cytokine Therapy in Wound Healing and Fibrotic Diseases

2001 • 189 citations

Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway

2002 • 187 citations

Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin

2001 • 184 citations

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

2002 • 165 citations

Chronic liver injury, TGF-β, and cancer

2001 • 156 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

2003 • 136 citations

Idiopathic pulmonary fibrosis: new insights in its pathogenesis

2002 • 133 citations

Interstitial fibrosis and growth factors.

2000 • 129 citations

Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy.

1999 • 128 citations

Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors.

1995 • 114 citations

The Extracellular Matrix Dynamically Regulates Smooth Muscle Cell Responsiveness to PDGFa

2000 • 91 citations

Induction of Lung Fibrosis in the Mouse by Intratracheal Instillation of Fluorescein Isothiocyanate Is Not T-Cell-Dependent

1999 • 84 citations

The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1

1999 • 84 citations

Distinct Role of Phosphatidylinositol 3-Kinase and Rho Family GTPases in Vav3-induced Cell Transformation, Cell Motility, and Morphological Changes

2002 • 84 citations

The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation

1997 • 56 citations

Augmentation of fibroblast proliferation by bleomycin.

1986 • 55 citations

Mechanisms of Pulmonary Fibrosis

2001 • 54 citations

Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis

2000 • 51 citations

Prevention of bleomycin-induced pulmonary fibrosis after adenovirus-mediated transfer of the bacterial bleomycin resistance gene.

1997 • 50 citations

Involvement of Cell-Cell Interactions in the Rapid Stimulation of Cas Tyrosine Phosphorylation and Src Kinase Activity by Transforming Growth Factor-β1

2002 • 40 citations

Interstitial Fibrosis and Growth Factors

2000 • 29 citations

A Molecular Basis for Bleomycin-induced Pulmonary Fibrosis

1986 • 13 citations

Deleted Work

1955 • 0 citations

Cited By (0)

No citing papers found in database

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents… (2004) – Journal of Clinical Investigation | Metascience Observatory Explorer