Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

1995 • 1,398 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Cytokine receptor signalling

1995 • 1,242 citations

Fc Receptors

1991 • 1,220 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*

1970 • 1,031 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

1994 • 866 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

1996 • 828 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Mutation of the proto‐oncogene c‐kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.

1994 • 816 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Requirement of c-kit for development of intestinal pacemaker system

1992 • 700 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Lymphotactin: a Cytokine that Represents a New Class of Chemokine

1994 • 668 citations

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

1994 • 666 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

1996 • 539 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Impaired Production and Increased Apoptosis of Neutrophils in Granulocyte Colony-Stimulating Factor Receptor–Deficient Mice

1996 • 507 citations

EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

1967 • 504 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

The thymic microenvironment

1993 • 459 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice

1996 • 452 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Diversity, rearrangement, and expression of murine T cell gamma genes

1986 • 405 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

1997 • 380 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Identification of a Committed Precursor for the Mast Cell Lineage

1996 • 379 citations

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1993 • 377 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Leukocyte Migration and Adhesion

1995 • 365 citations

Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

1995 • 365 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

1996 • 348 citations

Differential Requirements for α4 Integrins during Fetal and Adult Hematopoiesis

1996 • 347 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Cadherins and catenins in development

1996 • 344 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal

1995 • 313 citations

The generation and fate of thymocytes.

1990 • 309 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

The interleukin-2 receptor γ chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1

1993 • 306 citations

Developmental biology of hematopoiesis

1995 • 306 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells.

1985 • 305 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

TISSUE INTERACTION IN THE DEVELOPMENT OF THYMUS LYMPHOCYTES

1969 • 295 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

Regulation of Ras-mediated signalling: more than one way to skin a cat

1995 • 292 citations

Regulation of TCR α and β gene allelic exclusion during T-cell development

1992 • 284 citations

The surrogate light chain in B-cell development

1993 • 282 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Development in the thymus: it takes two to tango

1993 • 281 citations

Identification of a common T/natural killer cell progenitor in human fetal thymus.

1994 • 280 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.

1996 • 277 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Developmental biology of hematopoiesis

1995 • 268 citations

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

1996 • 268 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

Dendritic Cell Development in Culture from Thymic Precursor Cells in the Absence of Granulocyte/Macrophage Colony-stimulating Factor

1996 • 265 citations

A population of early fetal thymocytes expressing FcγRIIIII contains precursors of T lymphocytes and natural killer cells

1992 • 264 citations

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.

1992 • 263 citations

THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS

1997 • 262 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

Early αβ T cell development in the thymus of normal and genetically altered mice

1997 • 249 citations

Studies on T cell maturation on defined thymic stromal cell populations in vitro.

1992 • 249 citations

Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors

1990 • 249 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.

1996 • 241 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

1996 • 236 citations

Natural Killer Cells: From No Receptors to Too Many

1997 • 236 citations

Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system

1994 • 234 citations

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

1993 • 233 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

Analysis of the B-cell progenitor compartment at the level of single cells

1994 • 232 citations

Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice

1997 • 231 citations

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

1996 • 224 citations

Experimental analysis of the origin of cell types in the development of the mouse thymus

1961 • 224 citations

The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

1991 • 222 citations

Origin of the c-kit-positive interstitial cells in the avian bowel

1996 • 222 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

Hematopoiesis in mice lacking the entire granulocyte-macrophage colony- stimulating factor/interleukin-3/interleukin-5 functions

1996 • 217 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

1996 • 211 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

From white spots to stem cells: the role of the Kit receptor in mammalian development

1993 • 206 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

The Steel factor

1992 • 201 citations

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice

1996 • 201 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81

1997 • 196 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.

1992 • 194 citations

Circulation of Hematopoietic Progenitors in the Mouse Embryo

1996 • 193 citations

Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors.

1986 • 188 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

The status of Ig loci rearrangements in single cells from different stages of B cell development

1995 • 186 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Distinct stages of melanocyte differentiation revealed by analysis of nonuniform pigmentation patterns

1996 • 184 citations

The developmental relationship between NK cells and T cells

1992 • 183 citations

STEM-CELL MIGRATION IN DEVELOPING MYELOID AND LYMPHOID SYSTEMS

1967 • 183 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets

1989 • 180 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

DNA-PK: at the cross-roads of biochemistry and genetics

1997 • 169 citations

The Common γ-Chain for Multiple Cytokine Receptors

1995 • 168 citations

Leukemia inhibitory factor: A biological perspective

1991 • 167 citations

Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-A

1995 • 165 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice.

1992 • 161 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Inhibitory receptors, ITIM sequences and phosphatases

1997 • 160 citations

The regulation and function of p21ras during T-cell activation and growth

1995 • 160 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Murine thymocytes proliferate in direct response to interleukin-7

1989 • 157 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny.

1976 • 154 citations

Vertebrate non‐receptor protein–tyrosine kinase families

1996 • 154 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Vanin-1, a Novel GPI-Linked Perivascular Molecule Involved in Thymus Homing

1996 • 151 citations

Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.

1990 • 148 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 147 citations

Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4

1994 • 146 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo

1993 • 145 citations

Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus.

1996 • 145 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

Role of TCR ζ Chain in T Cell Development and Selection

1994 • 141 citations

Heterogeneity of hematopoietic stem cells

1993 • 139 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation

1995 • 138 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Cell migrations in embryos

1984 • 137 citations

Expression of genes of the T-cell antigen receptor complex in precursor thymocytes

1985 • 135 citations

The GTPase Rho has a critical regulatory role in thymus development

1997 • 135 citations

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.

1993 • 135 citations

Requirement for TNF-α and IL-1α in Fetal Thymocyte Commitment and Differentiation

1995 • 135 citations

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.

1992 • 134 citations

The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice

1996 • 132 citations

The effect of in vivo IL-7 deprivation on T cell maturation.

1995 • 132 citations

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.

1995 • 132 citations

Expression of two T cell receptor α chains on the surface of normal murine T cells

1995 • 131 citations

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

1996 • 130 citations

T Cell Receptor (TCR)-β Gene Recombination: Dissociation from Cell Cycle Regulation and Developmental Progression During T Cell Ontogeny

1997 • 128 citations

Genetic analyses of integrin function in mice

1996 • 124 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

1997 • 121 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.

1994 • 120 citations

Developmental Abnormalities in Mice Transgenic for Bovine Oncostatin M

1995 • 120 citations

IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing alpha beta or gamma delta T-cell receptors in vitro: synergism with IL-2.

1989 • 119 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

Induction of TCR Gene Rearrangements in Uncommitted Stem Cells by a Subset of IL-7 Producing, MHC Class II–Expressing Thymic Stromal Cells

1997 • 119 citations

The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.

1995 • 115 citations

A role for a pre-T-cell receptor in T-cell development

1993 • 114 citations

The c‐kit‐encoded tyrosine kinase regulates the proliferation of early pre‐B cells

1991 • 113 citations

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes

1987 • 112 citations

Rescue of T Cell-Specific V(D)J Recombination in SCID Mice by DNA-Damaging Agents

1994 • 112 citations

Intrathymic δ Selection Events in γδ Cell Development

1997 • 112 citations

Interleukin‐7 expression during mouse thymus development

1992 • 112 citations

Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells.

1994 • 111 citations

Intra‐ and extra‐thymic expression of the pre‐T cell receptor α gene

1995 • 109 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

A Role for CD81 in Early T Cell Development

1996 • 106 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

Dual T cell receptor beta chain expression on human T lymphocytes.

1995 • 106 citations

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1996 • 106 citations

Sox‐4 facilitates thymocyte differentiation

1997 • 105 citations

The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development.

1991 • 105 citations

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.

1996 • 104 citations

Cytokine production and requirements during T-cell development

1995 • 104 citations

Positive Selection of Thymocytes

1995 • 103 citations

Regulation of an extrathymic T-cell development pathway by oncostatin M

1996 • 102 citations

Thymic stem cells in mouse bone marrow

1994 • 101 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

IL-7 maintains the T cell precursor potential of CD3-CD4-CD8- thymocytes.

1991 • 100 citations

Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

1990 • 99 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

V(D)J recombination and the cell cycle

1995 • 98 citations

Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus.

1988 • 98 citations

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1995 • 97 citations

Transcriptional control of lymphoid development: lessons from gene targeting

1996 • 97 citations

T Cell Receptor δ Gene Rearrangement and T Early α (TEA) Expression in Immature αβ LineageThymocytes: Implications for αβ/γδ Lineage Commitment

1996 • 96 citations

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

1994 • 96 citations

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

1988 • 95 citations

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

1993 • 94 citations

Raf regulates positive selection

1996 • 90 citations

Receptors and signals in early thymic selection

1995 • 90 citations

Natural killer cell receptors

1997 • 88 citations

T cell functions in granulocyte/macrophage colony-stimulating factor deficient mice

1997 • 88 citations

Different Functions of the GTPase Rho in Prothymocytes and Late Pre-T Cells

1997 • 88 citations

CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.

1994 • 86 citations

CD2ϵ and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

1995 • 85 citations

Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins

1995 • 85 citations

Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins.

1991 • 82 citations

Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

1996 • 82 citations

Common Cytokine Receptor γ chain (γ_c)‐Dependent Cytokines: Understanding in vivo Functions by Gene Targeting

1995 • 81 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates

1996 • 79 citations

Fetal thymic organ cultures

1994 • 79 citations

Fibroblast dependency during early thymocyte development maps to the CD25⁺ CD44⁺ stage and involves interactions with fibroblast matrix molecules

1997 • 78 citations

T cell depletion in transgenic mice carrying a mutant gene for TCR-β

1989 • 77 citations

Functions of TCR and pre-TCR subunits: lessons from gene ablation

1996 • 77 citations

A signaling pathway governing early thymocyte maturation

1995 • 76 citations

Development of CD4−CD8+ cytotoxic T cells requires interactions with class I MHC determinants

1988 • 76 citations

The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate

1993 • 75 citations

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway.

1995 • 74 citations

Natural killer cell receptors specific for MHC class I molecules

1996 • 73 citations

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.

1996 • 73 citations

Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor β-chain gene

1985 • 72 citations

Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.

1992 • 72 citations

Cytokines: Shared receptors, distinct functions

1997 • 71 citations

Cytokine production by mature and immature thymocytes.

1991 • 69 citations

Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia.

1994 • 69 citations

Thymus-grafted SCID mice show transient thymopoiesis and limited depletion of V beta 11+ T cells.

1992 • 69 citations

Interleukin 7-induced expression of specific T cell receptor gamma variable region genes in murine fetal liver cultures.

1993 • 69 citations

Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

1995 • 68 citations

CD34-expressing human thymocyte precursors proliferate in response to interleukin-7 but have lost myeloid differentiation potential

1993 • 63 citations

In vitro development of B cells and macrophages from early mouse fetal thymocytes

1994 • 62 citations

Hematopoietic stem cells: challenges to expectations

1997 • 62 citations

Two Distinct Steps during Thymocyte Maturation from CD4−CD8− to CD4+CD8+ Distinguished in the Early Growth Response (Egr)-1 Transgenic Mice with a Recombinase-activating Gene–Deficient Background

1997 • 62 citations

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice.

1994 • 62 citations

The lymphocyte-specific tyrosine protein kinase p56lck.

1991 • 60 citations

Pathways from hematopoietic stem cells to thymocytes

1995 • 59 citations

Involvement of E-Cadherin in Thymus Organogenesisand Thymocyte Maturation

1997 • 59 citations

The Cell Cycle and V(D)J Recombination

1996 • 59 citations

Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation.

1990 • 58 citations

Specificity of leukocyte-endothelial interactions and diapedesis: physiologic and therapeutic implications of an active decision process

1993 • 58 citations

Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway.

1996 • 58 citations

T cell receptor β chain dimers on immature thymocytes from normal mice

1993 • 57 citations

Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells.

1996 • 54 citations

Development and function of T cells in T cell antigen receptor/CD3 ζ knockout mice reconstituted with FcɛRI γ

1997 • 54 citations

Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death.

1996 • 53 citations

Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells.

1996 • 53 citations

Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous.

1988 • 51 citations

TCR ζ chain in T cell development and selection

1997 • 51 citations

The high affinity Fc epsilon receptor gamma subunit (Fc epsilon RI gamma) facilitates T cell receptor expression and antigen/major histocompatibility complex-driven signaling in the absence of CD3 zeta and CD3 eta

1991 • 50 citations

Interactions Between c-kit and Stem Cell Factor Are Not Required for B-Cell Development In Vivo

1997 • 50 citations

Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene.

1995 • 50 citations

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.

1997 • 48 citations

Steel Factor (c-kit Ligand) Stimulates the in Vitro Growth of Immature CD3-/CD4-/CD8- Thymocytes: Synergy with IL-7

1994 • 48 citations

Antigenic phenotype and gene expression pattern of lymphohemopoietic progenitors during early mouse ontogeny.

1997 • 48 citations

Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.

1995 • 48 citations

α₆ integrins participate in pro‐T cell homing to the thymus

1995 • 48 citations

The majority of immature fetal thymocytes can be induced to proliferate to IL-2 and differentiate into cells indistinguishable from mature natural killer cells.

1993 • 47 citations

Proliferation Kinetics Associated with T Cell Receptor-β Chain Selection of Fetal Murine Thymocytes

1996 • 47 citations

The influence of positive selection on RAG expression in thymocytes

1995 • 46 citations

Early T‐cell Development in CD3‐deficient Mice

1995 • 45 citations

Intrathymic lymphoid precursor cells during fetal thymus development.

1993 • 43 citations

Hemopoietic progenitors in the murine fetal liver capable of rapidly generating T cells.

1997 • 43 citations

Allelic Exclusion in pTα-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-β Chains, but Less Efficient Inhibition of Endogeneous Vβ→ (D)Jβ Rearrangements in the Presence of a Functional TCR-β Transgene

1997 • 43 citations

Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis.

1992 • 42 citations

Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level inscid mice

1987 • 41 citations

Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?

1997 • 41 citations

B220 expression by T lymphoid progenitor cells in mouse fetal liver.

1997 • 37 citations

CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells

1996 • 36 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations

IL 7-induced T cell receptor-gamma gene expression by pre-T cells in murine fetal liver cultures.

1992 • 35 citations

T-cell specific rearrangement of T-cell receptor beta transgenes in mice.

1990 • 33 citations

Transgenic expression of interleukin 7 restores T cell populations in nude mice.

1995 • 32 citations

Domains of the TCR beta-chain required for early thymocyte development.

1996 • 30 citations

Are the IL-2 Receptors Expressed in the Murine Fetal Thymus Functional?

1989 • 30 citations

Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene

1995 • 29 citations

TCR isoform containing the Fc receptor γ chain exhibits structural and functional differences from isoform containing CD3ξ

1993 • 28 citations

Interleukin-7R alpha mRNA expression increases as stem cells differentiate into T and B lymphocyte progenitors.

1997 • 27 citations

Synergistic effect of colony-stimulating factors and IL-2 on prothymocyte proliferation linked to the maturation of macrophage/dendritic cells within L3T4-Lyt-2-Ia-Mac- cells.

1988 • 27 citations

Replacement of Pre-T Cell Receptor Signaling Functions by the CD4 Coreceptor

1997 • 27 citations

Pro‐T cells in fetal thymus express c‐kit and RAG‐2 but do not rearrange the gene encoding the T cell receptor β chain

1994 • 26 citations

Cytokine production profile of early thymocytes and the characterization of a new class of chemokine

1995 • 26 citations

Murine embryonic blood between day 10 and 13 of gestation as a source of immature precursor B cells

1980 • 25 citations

Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-beta 1 mechanism

1995 • 25 citations

Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.

1996 • 25 citations

Delayed maturation of CD4- CD8- Fc gamma RII/III+ T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice.

1996 • 24 citations

Transcription of the TCR-beta locus initiates in adult murine bone marrow.

1995 • 24 citations

Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice.

1996 • 23 citations

Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation.

1988 • 23 citations

Thymus in mice bearing the Steel mutation. Morphologic studies on fetal, neonatal, organ-cultured, and grafted fetal thymus.

1981 • 21 citations

The murine interleukin‐2 receptor γ chain gene: Organization, chromosomal localization and expression in the adult thymus

1994 • 21 citations

A Phenotype or Not: Targeting Genes in the Immune System

1992 • 21 citations

Implication of the common γ chain of the IL-7 receptor in intrathymic development of pro-T cells

1994 • 21 citations

Ontogeny and distribution of the murine B cell Fc gamma RII.

1992 • 20 citations

T lymphocyte development in the absence of Fcε receptor Iγ subunit: analysis of thymic-dependent and independent αβ and γδ pathways

1996 • 18 citations

Lineage relationships of the fetal thymocyte subset that expresses the β chain of the interleukin‐2 receptor

1993 • 15 citations

Thymic hyperplasia in transgenic mice caused by immortal epithelial cells expressing c‐kit ligand

1992 • 14 citations

Analysis of Gene Function in Lymphocytes by RAG-2-Deficient Blastocyst Complementation

1996 • 14 citations

Prothymocyte seeding in the thymus

1991 • 12 citations

Lck dependence of signaling pathways activated by γirradiation and CD3ε engagement in RAG-1^-/-immature thymocytes

1996 • 11 citations

Developmentally regulated Fcγ receptor expression in lymphopoiesis FcγR III (CD16) provides an ITAM motif for pro-T and pro-B-cells

1996 • 11 citations

In vitro growth of bone marrow-resident T cell precursors supported by mast cell growth factor and IL-3.

1992 • 9 citations

Pre-Thymic transcription of TCR genes by adult murine bone marrow cells

1996 • 9 citations

Regulation of Recombination Activating Gene Expression During Lymphocyte Development

1996 • 9 citations

Developmentally ordered appearance of a functional Fc gamma receptor on TCR V gamma 3 thymocytes. Evidence for stimulation-induced expression.

1994 • 6 citations

Antigen-receptor junctional diversity in growth-factor-receptor mutant mice

1998 • 5 citations

Genetic effects on immunity Inherited disorders of lymphocyte development and function

1996 • 3 citations

Reconstitution Properties of Thymus Stem Cells in Murine Fetal Liver

1993 • 3 citations

Expression and Function of Fc Receptors in the Thymus

1995 • 2 citations