Rescue of T Cell-Specific V(D)J Recombination in SCID Mice by DNA-Damaging Agents

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Positive selection of lymphocytes

1994 • 563 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes

1993 • 474 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1992 • 449 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire

1993 • 437 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

1991 • 295 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

A Quantitative Dose-Response Study of Lymphoid-Tumor Development in Irradiated C57 Black Mice<xref ref-type="fn" rid="fn1"><sup>2</sup></xref>

1952 • 234 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Oncogenic conversion of transcription factors by chromosomal translocations

1991 • 209 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

1993 • 193 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides.

1990 • 183 citations

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1994 • 157 citations

A cd3⁻ subset of cd4⁻8⁺ thymocytes: a rapidly cycling intermediate in the generation of cd4⁺8⁺ cells

1988 • 152 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

1989 • 128 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens.

1991 • 94 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P‐nucleotide additions in VJ‐coding joints

1991 • 72 citations

Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection.

1988 • 72 citations

Analysis of the defect in DNA end joining in the murine scid mutation.

1992 • 69 citations

Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes.

1993 • 61 citations

Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID).

1994 • 56 citations

Wild-type V(D)J recombination in scid pre-B cells.

1990 • 53 citations

Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.

1990 • 49 citations

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion.

1991 • 48 citations

T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.

1990 • 46 citations

Transcription of unrearranged antigen receptor genes in scid mice.

1988 • 42 citations

Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level inscid mice

1987 • 41 citations

Defective repair of radiation-induced chromosomal damage in <i>sci</i><i>d</i>/<i>scid </i>mice

1992 • 37 citations

Engraftment of human lymphoid cells into newborn SCID mice leads to graft-versushost disease

1993 • 36 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations

Frequent deletions in nine newly immortal human cell lines

1992 • 34 citations

High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice.

1993 • 32 citations

Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7

1989 • 32 citations

Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis.

1992 • 28 citations

V(D)J recombination in peritoneal B cells of leaky scid mice.

1993 • 28 citations

Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.

1993 • 23 citations

Scid mouse Pre-B cells with intracellular μ chains: analysis of recombinase activity and IgH gene rearrangements

1993 • 13 citations

Selected Abstracts from Physical Review D

1992 • 1 citations