pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells.

1992 • 191 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor.

1992 • 146 citations

Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.

1988 • 117 citations

Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.

1988 • 103 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.

1991 • 98 citations

Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells

1989 • 72 citations

Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance.

1989 • 72 citations

Stimulation of all T cells bearing V_β1, V_β3, V_β11 and V_β12 by staphylococcal enterotoxin A

1990 • 66 citations

Signal transduction by the SRC family of tyrosine protein kinases in hemopoietic cells.

1991 • 64 citations

Co-stimulation of T cell proliferation by transforming growth factor-beta 1.

1991 • 62 citations

Signaling mechanisms in T cells.

1991 • 53 citations

Fyn tyrosine kinase associated with Fc epsilon RII/CD23: possible multiple roles in lymphocyte activation.

1991 • 47 citations

Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.

1991 • 46 citations

Biological and Biochemical Properties of the c-src⁺ Gene Product Overexpressed in Chicken Embryo Fibroblasts

1989 • 39 citations

Induction of Immunological Unresponsiveness in vivo and in vitro by Conventional and Super‐Antigens in Developing and Mature T Cells

1991 • 29 citations

Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts.

1989 • 19 citations